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Register a new userStudy of the Effect of Electrostatic Charge on the Delivered Dose of Metered Dose Inhaler
دراسة تأثير الكهرباء الساكنة على الجرعة المتحررة من شكل إرذاذي معاير الجرعة
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تم إجراء دراسة تأثير الكهرباء الساكنة المتولدة في الحاضنة (actuator) جراء طريقة التجفيف على محتوى الجرعة المتحررة من عبوة شكل إرذاذي في حالتين: غسل الحاضنة و تجفيفها باستخدام قطعة قماش. غسل الحاضنة و تركها تجف في الهواء فقط. أًجريت الدراسة على شكل إرذاذي معاير الجرعة (metered dose inhaler) لكبريتات السالبوتامول من إنتاج شركة صناعة دوائية محلية. أظهرت النتائج أهمية طريقة تجفيف الحاضنة على محتوى الجرعة المحررة من المادة الفعالة، حيث إن محتوى الجرعات المحررة من عبوة الشكل الإرذاذي بعد غسل الحاضنة و تجفيفها باستخدام قطعة قماش لا تحقق المتطلبات الدستورية، و تقع خارج المجال المسموح به دستورياً (75-125%)، بينما محتوى الجرعات المتحررة بعد غسل الحاضنة، و تركها تجف وحدها تحقق المتطلبات الدستورية، و تقع ضمن المجال المقبول. يعزى اختلاف النتائج بين محتوى الجرعات في الحالتين السابقتين إلى الكهرباء الساكنة المتولدة في الحاضنة جراء عملية التجفيف.
A study of the effect of electrostatic charge that is generated in actuator due to drying methods on the delivered dose of metered dose inhaler has been done in tow cases: Washing actuator and drying it by a clothe. Washing actuator and let it dry alone. A study has been done on metered dose inhaler containing salbutmaol sulfate and manufactured by a local company. The results show the importance of drying methods on the delivered dose, the delivered doses of metered dose inhaler after washing the actuator and dry it by a clothe hadn't been achieved the USP-34 requirements (out of range 75-125%), while the delivered doses after washing actuator and let it dry alone had been achieved the USP-34 requirements. The difference in results between the two cases belong to electrostatic charge generated in actuator due to drying methods
References used
Anhoj, J.;Bisgaard, H.;Lipworth.B.J. Effect of Electrostatic Charge in Plastic Spacers on the Lung Delivery of HFA-Salbutamol in Children. Br J Pharmacol.47(3),1999,333-336
Anouk, C.A.; Sennbauser, F.H.; Wildhaber, J.H. Factor Affecting the Efficiency of Aerosol Therapy with Pressurized Metered Dose Inhalers through Plastic Spacers. SwissMed Wlky,2001,14-18
SwissMed Wlky,2001,14-18. 3. Deveswaran, R.; Bharath, S.; Basavaraj, BV.; Abraham, S.; Furtado, SH.; Madhavan, V. Concept and Techniques of Pharmaceutical Powder Mixing Process: A Current Update. Research J.Pharm and Tech.2(2).April,2009,245-249
Kwok, P.C.; Chan, H.H. Electrostatic of Pharmaceutical Aerosols. J Pharma Pharmacol.Dec;61(12),2009,1587-99.Doi:10.1211/jpp/61.12.0002
Mitchell, J.P.; Coppolo, D.P.; Nagel, M.W. Electrostatics and Inhaled Medications: Influence on Delivery via Pressurized Metered Dose Inhalers and Add on Devices. Respir Care,2007,Mar;52(3),283-300
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