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Prevalence of Parvovirus B19 in a group of thalassemia beta patients in Damascuse city

انتشار الفيروس الصغير B19 لدى مجموعة من مرضى التلاسيمية بيتا في مدينة دمشق

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 Publication date 2016
  fields Pharmacy
and research's language is العربية
 Created by Shamra Editor




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Parvovirus B19 infects children and adults , causing erythema infectiosum in children , polyarthritis in adults, aplastic crisis and chronic anemia in patients with hematological or immunological disorders, and fetal hydrops or fetal death .


Artificial intelligence review:
Research summary
تناولت هذه الدراسة انتشار الفيروس الصغير B19 بين مرضى الثلاسيمية بيتا في مدينة دمشق. تم جمع العينات من 275 مريضًا تتراوح أعمارهم بين 2 و51 عامًا من مركز العيادات الشاملة التخصصية في دمشق خلال الفترة من يناير 2015 إلى أبريل 2016. تم استخدام تقنية ELISA لتحري الأضداد النوعية للفيروس في مصول المرضى. أظهرت النتائج أن نسبة انتشار أضداد IgM للفيروس بلغت 6.2%، ولم يكن هناك فروق ذات دلالة إحصائية بين الجنسين أو الفئات العمرية المختلفة. كما أظهرت الدراسة أن هناك فروقًا ذات دلالة إحصائية في متوسط تركيز الخضاب في الدم بين المرضى الذين كانت نتائجهم إيجابية للفيروس وأولئك الذين كانت نتائجهم سلبية. توصي الدراسة بفحص وحدات الدم المخصصة لمرضى الثلاسيمية بشكل روتيني لتحري وجود الفيروس وتطوير استراتيجيات وقائية وعلاجية للسيطرة على العدوى.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة لأنها تسلط الضوء على انتشار الفيروس الصغير B19 بين مرضى الثلاسيمية في دمشق، وهي فئة معرضة بشكل كبير للعدوى بسبب حاجتهم المتكررة لنقل الدم. ومع ذلك، يمكن تحسين الدراسة من خلال زيادة حجم العينة وتوسيع نطاق البحث ليشمل مناطق جغرافية أخرى في سوريا. كما يمكن استخدام تقنيات أخرى مثل PCR لتحري الفيروس بشكل أكثر دقة. بالإضافة إلى ذلك، يمكن أن تكون هناك حاجة لمزيد من الدراسات لتحديد تأثير العدوى على الحالة الصحية العامة للمرضى وتطوير استراتيجيات علاجية ووقائية فعالة.
Questions related to the research
  1. ما هي نسبة انتشار أضداد الفيروس الصغير B19 بين مرضى الثلاسيمية في دمشق؟

    بلغت نسبة انتشار أضداد IgM للفيروس الصغير B19 بين مرضى الثلاسيمية في دمشق 6.2%.

  2. هل هناك فروق ذات دلالة إحصائية بين الجنسين في انتشار الفيروس الصغير B19؟

    لا، لم تظهر الدراسة فروق ذات دلالة إحصائية بين الجنسين في انتشار الفيروس الصغير B19.

  3. ما هي التقنية المستخدمة لتحري أضداد الفيروس الصغير B19 في هذه الدراسة؟

    تم استخدام تقنية ELISA لتحري أضداد الفيروس الصغير B19 في مصول المرضى.

  4. ما هي التوصيات التي قدمتها الدراسة للحد من انتشار الفيروس الصغير B19 بين مرضى الثلاسيمية؟

    توصي الدراسة بفحص وحدات الدم المخصصة لمرضى الثلاسيمية بشكل روتيني لتحري وجود الفيروس وتطوير استراتيجيات وقائية وعلاجية للسيطرة على العدوى.


References used
Heegaard ED. Brown KE. Human Parvovirus B19 Clin Microbial
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Parvovirus B19 infects children and adults, causing erythema infectiosum (fifth disease), polyarthritis, aplastic crisis and chronic anemia in patients with hematological or immunological disorders, and fetal hydrops or fetal death. This study ai ms to estimate the prevalence of B19 IgM in Damascus patients with thalassemia major..
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Aims of study: 1-To determine the prevalence and 2- the pattern of hypodontia in the permanent dentition in a sample of Syrian orthodontic patients who sought orthodontic treatment. Materials and Methods: The orthodontic records of 623 patients ag ed 12 to 34, who sought orthodontic treatment in the Department of Orthodontics, Dental faculty/Damascus University, during the last three years (2011-2014), were investigated to establish the prevalence of patients with one or more permanent missing teeth. Results: 1-The prevalence of hypodontia was 7.10% of the studied sample (7.49% in females, and 6.35% in males). Males were less affected than females with a ratio of 1:1.18 with no significant differences between genders (P = 0.063). 2-The most common missing tooth was maxillary lateral incisor (56.52%), the least common missing tooth was maxillary first molar (0.87%). Missing in the maxillary jaw was significantly more frequent than the mandible (P=0.041( with significantly more anterior teeth missing than posterior teeth (P=0.009). Conclusions: The prevalence of hypodontia showed in this study was within the range published in the literature. The patterns are similar to most reported patterns in the literature.
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