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Register a new userدراسة كيميا نسيجية مناعية لدور مستقبل عامل النمو البشروي EGFR في تحديد درجة خبث الإصابة بالسرطان البشروي شائك الخلايا في الحفرة الفموية
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Damascus University رسالة ماجستير
Publication date
2013
fields
Dentistry
and research's language is
العربية
Created by
Shamra Editor
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دراسة كيميا نسيجية مناعية لدور مستقبل عامل النمو البشروي EGFR في تحديد درجة خبث الإصابة بالسرطان البشروي شائك الخلايا في الحفرة الفموية
No English abstract
References used
David Hyde, Introduction to Genetic Principges, 2009 USA
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Background & Objective: This immunohistochemical study is to investigate the correlation between p53 & Ki67 and the grade of malignancy of squamous cell carcinoma, to estimate functional behavior of the cancerous cell by Ck17, and to compare the resu
lts with the histological grading.
Methods & Materials: 64 samples (biopsies) were chosen to check for p53, Ki67 & Ck17 at department of oral histology and pathology between 2002- 2009.
Conclusion: There is a strong positive correlation between the degree of malignancy and the signs of cellular atypism (morphological changes) and the immunhistochemical positivity specially p53 and Ki67, and there is a strong negative correlation between the positivity of p53, Ki67 and the plasmolymphatic
infiltrate. We must be sure of the correct diagnosis of squamous cell carcinoma by histological and immunohistochemical examination, and attention should be given to use more than one immune reactive.
This retrospective study is to correlate oral squamous cell carcinoma with age,
gender and location of lesion, and to investigate the correlation between the grade of the malignancy and
lymph nodes in patients of the faculty of dentistry, Damascus university.
Although malignant fibrous histiocytoma are uncommon in the oral
cavity. We observed these neoplasms in jawbones in 7 cases (5 in the
maxilla and 2 in the mandible) affecting males aged 24 to 51 years.
Histologically the pleomorphic pattern is dom
inant, and all patterns are
characterized by active proliferative cells, and scattered histiocytes
which stained positively by CD74 and CD68
These lesions cause radiolucencies with poorly defined margins and no
radiographically distinct features.
Differential diagnosis must involve osteosarcoma, chondrosarcoma and
fibrosarcoma .
The treatmenm of choice is wide surgical excision.
The protein p53 is the guardian of the cell gene contents from changes, and the
gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell
carcinoma’s cases producing defective protein .Studies have not detailed the
expression ratio of the
defective protein Within the cancer cells, also studies have less details about the cases which did not show
a mutated protein.
يقوم هذا البحث باجراء دراسة وبائية للأنماطو تحت الأنماط النسيجية للمفومالاهودجكن المشاهدة في مشفى مركزي تعليمي هو مشفى المواساة و ذلك في العقد اللمفاوية و في الأعضاء خارج العقد اللمفاوية بشكل بدئي أو توضعات ثانوية و معرفة نسبها و توزعها في كل الأعمار
و القاء الضوء على أهمية و دور التلوينات المناعية النسيجية الكيميائية في وضع تشخيص نهائي و ذلك وفقا لتصنيف عام 2008.
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