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Damascus University رسالة ماجستير
Publication date
2015
fields
Dentistry
and research's language is
العربية
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Shamra Editor
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لا يزال السرطان شائك الخلا يا الفموي يمتلك معدل وفيات ملحوظ على الرغم من التقدم الكبير في مجال الجراحة و علم الأورام، لذلك فقد أصبح من الضروري تقصي التبدلات التي تصيب بروتينات الخلية الشائكة في سياق تحولها الورمي.
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References used
BRUSES, J. L. 2006. N-cadherin signaling in synapse formation and neuronal physiology. Mol Neurobiol, 33, 237-52.
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Aim of study: study of the differences in the protein expression of
Cyclin-dependent Kinase CdK1, CdK2 in Oral Squamous Cell
Carcinoma (OSCC) and in clinically- normal oral mucosa.
Cancer of the lip is relatively common malignancy of the head and neck region.
Squamous cell carcinoma most frequently occurs in the lower lip (LLSCC) or Lower Lip Squamous Cell
Carcinoma. This study aimed to evaluate the correlation between the in
volved lymph nodes level and the
tumor appearance, greatest dimension (T) and its degree of differentiation.
Cancer stem cells in solid tumors are a "rare" group of cells and
their role in carcinogenesis has been proven during the past few
years. The pursuit for specific oral epithelial stem cell surface
markers leads to the identification of markers su
ch as CD44
and Bmi-1. The combination between CD44 which has been
considered a potential prognostic marker for cancer stem cells in
Head and Neck Squamous Cell Carcinoma (HNSCC), and Bmi-1
the pluripotency stemness marker may lead to identify the cells
sharing the properties of both markers and could give a closer look
into its appearance and density in the tissue. The aim of this study
was to study the percent of cells stained positive for both markers
and the histological grade of (HNSCC) and the anatomic location
of the tumor. Statistical analysis showed that higher density of
positive stained cells for both markers was in the severe grade of
the tumor, whereas the second higher ratio was in the mild grade
then the moderate , there was no significant association between the density of cells and the anatomical location. Our results suggest that the two markers together could be used as prognostic factors for patients with even mild grade SCC, which might help in prediction of recurrence.
Recombinant human bone morphogenetic protein-2 (rhBMP-2 ) is
effectively to regenerate defects of the maxillary and mandible
bones. Such defects are sometimes caused by resection of oral
squamous cell carcinoma (OSCC) yet the biologic effects of
rhBMP-2 on this malignancy and its histological relations and the
ability of invasion and metastasis are not fully clear.
Aim of the study : this study aimed to investigate the effects of
rhBMP2 on E-cadherin expression , which plays a pivotal role in the
cellular adhesion through the adherent junctions.
Background & Objective: This immunohistochemical study is to investigate the correlation between p53 & Ki67 and the grade of malignancy of squamous cell carcinoma, to estimate functional behavior of the cancerous cell by Ck17, and to compare the resu
lts with the histological grading.
Methods & Materials: 64 samples (biopsies) were chosen to check for p53, Ki67 & Ck17 at department of oral histology and pathology between 2002- 2009.
Conclusion: There is a strong positive correlation between the degree of malignancy and the signs of cellular atypism (morphological changes) and the immunhistochemical positivity specially p53 and Ki67, and there is a strong negative correlation between the positivity of p53, Ki67 and the plasmolymphatic
infiltrate. We must be sure of the correct diagnosis of squamous cell carcinoma by histological and immunohistochemical examination, and attention should be given to use more than one immune reactive.
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