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Register a new userComparison of Radiotherapy Plans for Esophageal and Lung Tumors Using 3DCRT and IMRT Technology
مقارنة خطتي المعالجة الإشعاعية لأورام المري والرئة بتقنيتي 3DCRT وIMRT
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Tishreen University ورقة بحثية
Publication date
2020
fields
Medicine
and research's language is
العربية
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Shamra Editor
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جرت دراسة خطط معالجة لمرضى أورام الرئة والمري، تم تصويرهم بتقنية التصوير المقطعي المحوري المحوسب (PHILIP TYPE) وأرسلت صورهم إلى نظام تخطيط العلاج Treatment Planning System – TPS (ECLIPS type)، الذي يحدد فيه الطبيب الأورام والأعضاء المعرضة للخطر. تم إنشاء خطتي المعالجة الإشعاعية التقليدية ثلاثية الأبعاد 3D-Conformal Radiotherapy (3DCRT) والمعالجة الإشعاعية بالحزمة المعدلة الشدة Intensity-modulated radiation therapy (IMRT) لنفس المرضى. تمت مقارنة خطتي العلاج برسم بياني جرعة - حجم Dose Volume Histogram (DVH). لوحظ أن توزع الجرعة الإشعاعية لخطة المعالجة الإشعاعية بتقنية IMRT أكثر ملاءمة لحجم الورم السريري clinical target volume - CTV وتوفر المزيد من الحماية للأعضاء المحيطة بالورم، لكنها تستغرق زمناً أطول منه في حالة تقنية 3DCRT. لذلك من الضروري تحديد المرضى الذين تجب معالجتهم بإحدى التقنيتين (3DCRT or IMRT) أو تقنية أخرى اعتماداً على الجرعة الكاملة الممنوحة لـCTV والزمن الذي تستغرقه عموماً.
Treatment plans were studied for patients with lung and esophageal tumors, patients were imaged using CT-Scan (PHILIP TYPE) and the images were sent to the Treatment Planning System-TPS (ECLIPS type), the system in which the doctor identified the tumor and at-risk organs. Conventional 3D-Conformal Radiotherapy (3DCRT) and Intensity-Modulated Radiotherapy (IMRT) plans were created for the same patients. Treatment plans were compared according to the Dose Volume Histogram (DVH).It was observed that the radiation dose distribution of radiotherapy plans using IMRT technique better suited to tumor size (CTV) and protecting more organs surrounding the tumor, but it takes longer than 3DCRT technology. Therefore it is necessary to determine which patients should be treated with one technique (3DCRT or IMRT) or another technique depending on the full dose given to CTV and the time it generally takes.
References used
Chui CS . , Chan MF . , Yorke E . , Spirou E . , Ling CC. Delivery of Intensity - modulated radiation therapy with a conventional multileaf collimator: Com parison of dynamic and segmental methods. Med Phys. , 2001; 28( Dec ): 2441 - 2449
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The research aims to make a statistical approach to the cases of esophageal atresia by
its types and incidence, and to study the surgical treatment outcome and choose the best
method of treatment and follow up.
The study included 27 newborn patien
ts admitted in the Neonatal Intensive Care Unit
at Al-Assad University Hospital and Tishreen University Hospital in Lattakia, due to
diagnosis of esophageal atresia or tracheoesophageal fistula, from the beginning of January
2010 until the end of 2015. 14 of patients were males and 13 were females. Gross
classification of esophageal atresia was used, type (C) was found in 21 cases, type (A) was
found in 4 cases, type (E) was found in 2 cases, while type (B) and (D) were not seen. We
studied The clinical symptoms in newborn patients with this malformation, radial and
laboratory findings and associated malformations. We used esophageal contrast study
insure the diagnosis when needed. With type (C), we did primary anastomosis in 20 cases
and cervical esophagostomy with gastrostomy in only 1 case. With type (A), we did
esophagostomy with gastrostomy in all cases. With type (E), we closed the fistula with
cervical approach in all cases. The survival rate was 70.4%. Spitz classification was used
for risk assessment. The incidence of complications included anastomotic leakage 30% and
anastomotic stricture 69.2%.
Reflux Esophagitis was diagnosed in 50 % of Acidic Gastro Esophageal Reflux
Disease cases only.
This study aimed to detect the association between Endoscopic Reflux Esophagitis and acidic
Gastroesophageal Reflux disease.
The aim of the study is repairing some partially damaged
archeological wood and restoration it before being completely
damaged. For achieving this aim, the radiation technology was used in preparing some polymer blends such as Poly (vinyl alcohol)
(PVA), Poly ethylene glycol (PEG), acrylic acid (AAC), and Acryl amid (AAm) to improving adhesion forces of polymer with wood and protecting it. The results show that the best mechanical
properties was achieved by using Poly(vinyl) alcohol (PVA), acrylic
acid (AAC), and acryl amid (AAm). Also, results show that by
increasing the ratio of acrylic acid (AAC), the tensile strength,
adhesion force, hardness, transparency, are increasing. The best
tensile strength obtained was 4.79 MPa for polymer blends contains 18/% acrylic acid, 6% acryl amid, 12% poly (vinyl alcohol) when exposing to Ultra-Violet ray dose of 210 . Results, also showed that the exposing of wood to Ultra-Violet ray dose of 250 [Gry] was enough for doing sterilization, purification.
Larynx cancer is the most common cancer of the head and neck with the exception of
the skin and it accounts for 2% of all cancer diagnoses, its genesis is directly associated
with alcohol drinking and smoking, squamous cell carcinoma (SCC) is the m
ost common
histological type (95%) of larynx cancer.
Aim: The purpose of this study was to evaluate 3D conformal radiotherapy of accelerated
system for early larynx cancer and to estimate acute and late toxicity which appear because
of irradiated normal tissues around the tumor (thyroid gland, spine cord, ….) and also to
evaluate the rate of recurrence and survival.
Materials and methods: The study was performed of 44 patients of scc larengeal cancer
stage T1/T2, that underwent RT (2015 – 2017), 84% with glottic cancer, the median age
was 63 years, all patients were treated 3D conformal RT, Total dose between (60-66) Gy,
2Gy/fraction (5 fractions in week).Our analysis was to evaluate the acute and late toxicity
dure and after radiotherapy, and also the rate of recurrence and survival.
Results: The most toxicity was dysphagia (42 PTs) 96%, radiodermitis (30 PTs) 70%, the
least toxicity was tooth damage. No evidence of late toxicity, the rate of recurrence (11
PTs) 25%, metastases occur in (1 PT). (6/ 41 PTs) 16.4% were dead.
Conclusion: Radiotherapy is the important role to control early larynx cancer, and 3DRadiotherapy
is giving a large dose to treat the tumor and save the normal tissues around
the tumor from effect of radiation, therefor absence the late toxicity.
Using the Mont Carlo code (MCNP4C2), doses were calculated for organs of
interest such as intestine, urinary bladder, rectum, vagina uterus, pancreas,
spleen, liver, spinal cord and kidneys while patient was undergoing cervix
brachytherapy by LDR
instrument (Cs-137).
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