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Register a new userData Mining on DNA Sequences of Hepatitis B Virus
استخراج المعرفة من سلاسل الحمض النووي لفيروس التهاب الكبد ب
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Publication date
2018
and research's language is
العربية
Authors
روشان محمدعلي( طالب )
Created by
Wesal Ali
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إنّ الهدف الأساسي من هذا البحث : هو تحديد العلامات الجينية لفيروس الالتهاب الكبدي الوبائي (B ) يسمى اختصارا ً ب (HBV ) والذي يكون مرتبط بشكل رئيسي بسرطان الكبد (HCC) وذلك عن طريق ميّزة استخراج المعلومات المفيدة من البيانات كبيرة الحجم التي تمثل العنصر الرئيسي في مجال المعلوماتيّة الحيويّة Bioinformatics وبشكل رئيسي يتم ذلك من تطوير فكرة مقارنة سلاسل DNA الكاملة ل HBV مع السلاسل الموجودة لدى المرضى الذين يعانون من السرطان الكبدي الوبائي و كذلك المرضى اللذين لا يعانون منه . إنّ إطار التنقيب عن البيانات data mining framework (الذي نقصد به ِ؛ جمع وتحليل كميّات كبيرة من البيانات لإيجاد علاقة منطقية فيما بينها بحيث تلخّص هذه البيانات بطريقة جيّدة ) يتضمن تحليل التطور الجيني molecular evolution analysis وعملية العنقدة clustering و feature selection وتعليم المصنف classifier learning وعملية التصنيف classification حيثُ سيتم توضيح كيفيّة توظيفها جميعا ً في هذا البحث.
No English abstract
References used
[1] R.P. Beasley, L.Y. Hwang, C.C. Lin, and C.S. Chien, “Hepatocellular Carcinoma and Hepatitis B Virus. A Prospective Study of 22 707 Men in Taiwan,” Lancet, vol. 2, pp. 1129-1133, 1981 .
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Several studies and reports have indicated the prevalence of hepatitis D virus
infection in many parts of the world at different rates , Ranging from areas of
epidemiological and areas with a low prevalence of it.
Till now there is no study in Syr
ia shows us the prevalence of viruse Delta in chronic
hepatitis B patients .
The aim of our study was to determine the current prevalence of hepatitis D in
chronic hepatitis B patients . And to take appropriate measures in dealing with these
patients due to the increased risk of liver disease in the event of injury by it .
77 patients with chronic hepatitis B certainly proved with PCR analysis
25 women and 52 men visiting the center of hepatitis in Latakia were tested for
antibody to hepatitis D virus (anti-HDV) by ELISA test .
The results indicate a positive antibody in three patients (women and 2 men) and the
prevalence was 3.8% , which point to a moderate prevalence of hepatitis D comparing with
neighboring countries.
The possible correlation between HLA system and various course of hepatitis B
has been studied in 346 subjects: 277 normal subjects, 27 HBsAg+ patients, 21
post hepatitis B liver cirrhosis patients, and 21 liver cirrhosis without previous
HBV infe
ction patients. Increased frequencies of A23, B21, B51 found in HBsAg+,
A28, B55 in post HBV cirrhosis, and higher frequency of B35 in normal subjects.
Hepatitis C is affected by human behaviors especially drugs , diets ,activities
smoking , sexy behaviors and alcohol , so it is very important to change health behaviors
by patient to control of disease and avoid complications .
Objective : to ass
ess the effects of health behaviors on liver function among
hepatitis C patients .Setting :The study was carried out in the Chronic Liver Hepatitis
Center in Alwatany hospitalization in Lattakia province.Subjects::Thesample comprised
40 patients chosen randomly from the two genders who have hepatitis C out in the chronic
liver hepatitis center in Alwatany hospitalization in Lattakia province during the research
time. Tool :Data were collected using the following tools:Tool I Questionnaire: It was
developed by the researcher and include items related to: demographic patients data ,
clinical data , questions about ( patients , information of disease , risk factors, healthy
behaviors : (diet – treatment regimens – activities and habits)) Tool II : Liver function
assessment sheet by using Child Pugh scale.Tool III :Patientcompliance check list which
include questions about complianceGuidenceProshor.guide line has been developed by the
researcherThe patients participated in 3 sessions .Each session (45minutes).Results: liver
function were advanced of patient at the experimental group which applied the guide line
more than patient at the control group because of Appling guide line .Recommendations :
Chronic Liver Hepatitis Centers have been containing proshorsshow the impact of these
health behaviors on the liver work and performing their functions as normal.
Aim: Hepatitis B is a dangerous infection disease which can transmit occupational through dental practice. This study was planned to evaluate the knowledge regarding hepatitis B infection among dentists in Lattakia city. Materials and methods: an Hep
atitis B questionnaire was prepeared, includes information about Hepatitis B infected, transmission, prevention and vaccination. The questionnaire was distributed randomaly through dentists, Data were collected and statistical analysis were conducted. Results: the response rate was (63%), and the dentists level of education regarding hepatitis B was only (57%). On the other hand the specialist dentists level was better than non-specialist dentists (P<0,05). Whereas the male and female level of education was the same (P>0,05). Finally (70%) of responders dentists have completed the hepatitis B vaccination. Conclusion: under the conditions of this study, the dentists level education regarding hepatitis B infection is low, so there is a need to promote about hepatitis B among dentists. HBV immunization should be made mandatory for health care workers.
تقترح هذه الورقة استخدام تقنيات استخراج المعرفة للكشف عن غسيل الاموال في الأنظمة المصرفية بالاضافة الى ذكر نظام مطبق للكشف عن غسيل الاموال باستخدام خوارزمية clope
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