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Register a new userPrevalence of hepatitis D antibodies in chronic hepatitis B patient
دراسة انتشار أضداد التهاب الكبد د لدى مرضى التهاب الكبد ب المزمن
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أشارت العديد من الدراسات و التقارير إلى انتشار فيروس التهاب الكبد د في مناطق عديدة من العالم بنسب مختلفة ,تتراوح بين مناطق وبائية و مناطق ذات انتشار منخفض . و للوقت الحالي لا تتواجد دراسة منشورة في سوريا تبين لنا نسبة انتشار هذا الفيروس بين مرضى التهاب الكبد ب المزمن . لذلك كان الهدف من هذا البحث معرفة معدل انتشار فيروس التهاب الكبد د لدى مرضى التهاب الكبد ب المزمن و ذلك لاتخاذ الاجراءات المناسبة في معالجة هؤلاء المرضى و ذلك نظرا لزيادة خطورة المرض الكبدي في حالة الاصابة به . 77 مريض بالتهاب الكبد ب المزمن و المؤكد بتحاليل سلسلة البوليمراز PCR 25 من النساء و 52 من الرجال من مراجعي مركز التهاب الكبد في مديرية صحة اللاذقية خضعوا لتحري أضداد فيروس د بتقنية ELISA فكانت النتائج تشير الى ايجابية الاضداد لدى ثلاثة مرضى ( امرأة و رجلان ) فكانت نسبة الانتشار تقدر ب 3.7 % من المرضى . مما يشير إلى نسبة انتشار متوسطة للفيروس مقارنة مع الدراسات المنشورة في دول الجوار .
Several studies and reports have indicated the prevalence of hepatitis D virus infection in many parts of the world at different rates , Ranging from areas of epidemiological and areas with a low prevalence of it. Till now there is no study in Syria shows us the prevalence of viruse Delta in chronic hepatitis B patients . The aim of our study was to determine the current prevalence of hepatitis D in chronic hepatitis B patients . And to take appropriate measures in dealing with these patients due to the increased risk of liver disease in the event of injury by it . 77 patients with chronic hepatitis B certainly proved with PCR analysis 25 women and 52 men visiting the center of hepatitis in Latakia were tested for antibody to hepatitis D virus (anti-HDV) by ELISA test . The results indicate a positive antibody in three patients (women and 2 men) and the prevalence was 3.8% , which point to a moderate prevalence of hepatitis D comparing with neighboring countries.
References used
Abbas Z, Afzal R; Life cycle and pathogenesis of hepatitis D virus: A review. World J Hepatol. 2013 Dec 27;5(12):666-675
Baron S, editor. Medical Microbiology. 4th edition Galveston (TX): University of Texas Medical Branch at Galveston; 1996
(Rizzetto M. Hepatitis D: Clinical Features and Therapy .Department of Gastroenterology, Molinette, University of Torino, Torino, Italy 2010;28:139– 143 (DOI:10.1159/000282077
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إنّ الهدف الأساسي من هذا البحث :
هو تحديد العلامات الجينية لفيروس الالتهاب الكبدي الوبائي (B ) يسمى اختصارا ً ب (HBV ) والذي يكون مرتبط بشكل رئيسي بسرطان الكبد (HCC) وذلك عن طريق ميّزة استخراج المعلومات المفيدة من البيانات كبيرة الحجم التي
تمثل العنصر الرئيسي في مجال المعلوماتيّة الحيويّة Bioinformatics وبشكل رئيسي يتم ذلك من تطوير فكرة مقارنة سلاسل DNA الكاملة ل HBV مع السلاسل الموجودة لدى المرضى الذين يعانون من السرطان الكبدي الوبائي و كذلك المرضى اللذين لا يعانون منه .
إنّ إطار التنقيب عن البيانات data mining framework (الذي نقصد به ِ؛ جمع وتحليل كميّات كبيرة من البيانات لإيجاد علاقة منطقية فيما بينها بحيث تلخّص هذه البيانات بطريقة جيّدة ) يتضمن تحليل التطور الجيني molecular evolution analysis وعملية العنقدة clustering و feature selection وتعليم المصنف classifier learning وعملية التصنيف classification حيثُ سيتم توضيح كيفيّة توظيفها جميعا ً في هذا البحث.
The possible correlation between HLA system and various course of hepatitis B
has been studied in 346 subjects: 277 normal subjects, 27 HBsAg+ patients, 21
post hepatitis B liver cirrhosis patients, and 21 liver cirrhosis without previous
HBV infe
ction patients. Increased frequencies of A23, B21, B51 found in HBsAg+,
A28, B55 in post HBV cirrhosis, and higher frequency of B35 in normal subjects.
Hepatitis C is affected by human behaviors especially drugs , diets ,activities
smoking , sexy behaviors and alcohol , so it is very important to change health behaviors
by patient to control of disease and avoid complications .
Objective : to ass
ess the effects of health behaviors on liver function among
hepatitis C patients .Setting :The study was carried out in the Chronic Liver Hepatitis
Center in Alwatany hospitalization in Lattakia province.Subjects::Thesample comprised
40 patients chosen randomly from the two genders who have hepatitis C out in the chronic
liver hepatitis center in Alwatany hospitalization in Lattakia province during the research
time. Tool :Data were collected using the following tools:Tool I Questionnaire: It was
developed by the researcher and include items related to: demographic patients data ,
clinical data , questions about ( patients , information of disease , risk factors, healthy
behaviors : (diet – treatment regimens – activities and habits)) Tool II : Liver function
assessment sheet by using Child Pugh scale.Tool III :Patientcompliance check list which
include questions about complianceGuidenceProshor.guide line has been developed by the
researcherThe patients participated in 3 sessions .Each session (45minutes).Results: liver
function were advanced of patient at the experimental group which applied the guide line
more than patient at the control group because of Appling guide line .Recommendations :
Chronic Liver Hepatitis Centers have been containing proshorsshow the impact of these
health behaviors on the liver work and performing their functions as normal.
Aim: Hepatitis B is a dangerous infection disease which can transmit occupational through dental practice. This study was planned to evaluate the knowledge regarding hepatitis B infection among dentists in Lattakia city. Materials and methods: an Hep
atitis B questionnaire was prepeared, includes information about Hepatitis B infected, transmission, prevention and vaccination. The questionnaire was distributed randomaly through dentists, Data were collected and statistical analysis were conducted. Results: the response rate was (63%), and the dentists level of education regarding hepatitis B was only (57%). On the other hand the specialist dentists level was better than non-specialist dentists (P<0,05). Whereas the male and female level of education was the same (P>0,05). Finally (70%) of responders dentists have completed the hepatitis B vaccination. Conclusion: under the conditions of this study, the dentists level education regarding hepatitis B infection is low, so there is a need to promote about hepatitis B among dentists. HBV immunization should be made mandatory for health care workers.
Background:Microscopic colitis (MC) encompasses collagenous and lymphocytic
colitis and is diagnosed by histopathological changes of random biopsies which tacken
from each segment of normal macroscopically colonic mucosae from patients who have
ch
ronic watery diarrhea of unknown etiology.
Aims:Prevalence of microscopic colitis in patients with chronic watery diarrhea and
have endoscopically normal colon .
Materials and Methods:We prospectively enrolled 84 patients reviewed in
ALASSAD and TISHREEN HOSPITALS between March 2015 until June 2016 .These
patients were having watery diarrhea more than 3 times a day for more 4 weeks. Atotal 84
patients were enrolled for a total colonoscopy until terminal ileum . Two biopsies were
obtained from all colonic segments and terminal ileum for diagnosed of microscopic
colitis. On histopathologic examination, criteria for lymphocytic colitis (intraepithelial
lymphocyte ≥ 20 per 100 surface epithelial cells, change in surface epithelium,
mononuclear infiltration of the lamina propria) and collagenous colitis (subepithelial
collagen band thickness ≥ 10 μm) were explored.
Results:Microscopic colitis was diagnosed in 33 (39%)patients {22lymphocytic
colitis,11collagenous colitis} . Female/Male: 15/18, mean age at diagnosis of microscopic
colitis : 37 year, range: 20-69, the median duration of diarrhea: 9.5 monthes , the median
number of bowel movements per day:5 times .And the common symptoms are:
abdominal pain and flatulence.
Conclusion :Biopsy of Syrian patients with the diagnosis of chronic watery diarrhea
of unknown etiology and normal colonoscopic findings will reveal microscopic colitis in
approximately 39% of the patients. Lymphocytic colitis is two times more frequent than
collagenous colitis in these patients.
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