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Register a new userApplication of Mie theory based electromagnetic scattering for differentiation between normal and cancerous cervical cells
تطبيق نظرية مي للتبعثر الكهرومغناطيسي للتمييز بين الخلايا السليمة و الخلايا السرطانية لأنسجة عنق الرحم
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وسام بشير( باحث )
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نقوم في هذا البحث بتطبيق نظرية التبعثر الكهرومغناطيسي لدراسة التبعثر الضوئي في الخلايا الحية لأنسجة عنق الرحم و بشكل محدد كيفية تأثر خواص التبعثر الضوئي في الخلايا الحية السليمة و الخلايا السرطانية بالتغيرات الشكلية و الفيزيولوجية التي تحدث في هذه الخلايا و مكوناتها عند إصابتها بخلل التنسج بدرجاته المختلفة.
This paper presents the application of electromagnetic wave scattering in human cervical cells. Particularly, studying the effect of morphological and physiological alterations on the properties of light scattering. Tissue alterations are caused by multi-grade dysplastic cervical cells and its internal structures.
References used
WILSON R. H, CHANDRA M, SCHEIMAN J, SIMEONE D, MCKENNA B, PURDY J, and MYCEK M.A, 2009 - Optical spectroscopy detects histological hallmarks of pancreatic cancer, Optics Express 17,17502p
GREENING G, JAMES H, DIERKS M, VONGKITTIARGORN N, OSTERHOLM S, RAJARAM N. AND MULDOON T, 2016 - Towards monitoring dysplastic progression in the oral cavity using a hybrid fiber-bundle imaging and spectroscopy probe, Scientific Reports, 6p
BACKMAN V., GOPAL V., KALASHNIKOV M., BADIZADEGAN K., GURJAR R., WAX A., GEORGAKOUDI I., MEULLER M., BOONE C. W., et al., 2001 - Measuring cellular structure at sub micrometer scale with light scattering spectroscopy, IEEE Journal of Selected Topics in Quantum Electronics 7, 887p
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The research was conducted in the department of obstetrics and gynecology at Al-Assad university hospital in Lattakia in the period between (1/1/2014) – (30/6/2015). The study included (100) patient, who submitted to colposcopy and Papanicolaou smear
to detect the effect of early marriage (early onset of sexual activity) on colposcopic and cellular finding in cervix . The results in (early married women) group (50) patient were compared to control group from patients who (not early married women)group (50) patient. We found that there was important difference in the rate of abnormal colposcopic findings : This rate in early married women was (26%) and in the second was (12%). We also found that there was important difference in the rate of abnormal cellular findings: This rate in early married women was (18%) and in the second was (8%). This assure the effect of early onset of sexual activity (early marriage) on colposcopical and cellular finding in cervix with assuring on the importance of frequent colposcopy and Papanicolaou smear test.
This research aims at establishing
and testing protocols for isolation, in vitro proliferation, phenotyping, and
differentiation of MSCs embedded in umbilical cord tissues of Syrian
newborns.
MSCs were isolated from two caesarian births depending
on their
adherence characteristic on plastic surfaces, and cells were cultured in MSC
medium for their growth and proliferation. Cell phenotyping was performed by
flow cytometry using fluorescent monoclonal antibodies specific to MSCs’
surface markers. Cultured cells were passed several times and a portion of
these cells was cryopreserved in liquid nitrogen, and cell viability was assessed.
Differentiation of these MSCs into adipocytes was conducted using culture
medium Indomethacin and hydrocortisone.
Cancer stem cells in solid tumors are a "rare" group of cells and
their role in carcinogenesis has been proven during the past few
years. The pursuit for specific oral epithelial stem cell surface
markers leads to the identification of markers su
ch as CD44
and Bmi-1. The combination between CD44 which has been
considered a potential prognostic marker for cancer stem cells in
Head and Neck Squamous Cell Carcinoma (HNSCC), and Bmi-1
the pluripotency stemness marker may lead to identify the cells
sharing the properties of both markers and could give a closer look
into its appearance and density in the tissue. The aim of this study
was to study the percent of cells stained positive for both markers
and the histological grade of (HNSCC) and the anatomic location
of the tumor. Statistical analysis showed that higher density of
positive stained cells for both markers was in the severe grade of
the tumor, whereas the second higher ratio was in the mild grade
then the moderate , there was no significant association between the density of cells and the anatomical location. Our results suggest that the two markers together could be used as prognostic factors for patients with even mild grade SCC, which might help in prediction of recurrence.
Mankind is still suffering from many diseases , and with the
development of civilization there are many diseases that appear with
different clinical types , but tumors, especially malignant , are still very
important.
Cervical cancer is the secon
d common cancer in women , as it is the cause of
more than 200.000 deaths annually. Hence the importance of early detection
of cervical cancer and of decreasing mortality.
Cervix cancer is one of the most important gynecological
cancers ,which is possible to be reduced by using early precancerous
detecting technics .
Objective : The aim of the study is to highlighten the colposcopy as a device
for early detection o
f precancerous lesions in the cervix , and compare the
results with histopathology .
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