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Register a new userSynthesis of new compounds for Hetrocyclic (Thiazole, Thiadiazole, Thiazolidine, Azolidinone) containing Fluorine moiety and study of antibacterial activity of prepared compounds
اصطناع مركبات جديدة للحلقات غير المتجانسة (تيازول، تياديازول، تيازوليدينون، أزوليدينون) مرتبطة مع الفلورين و دراسة الفعالية المضادة للبكتيريا لها
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Tishreen University ورقة بحثية
Publication date
2017
fields
Chemistry
and research's language is
العربية
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Shamra Editor
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قمنا بتصنيع بعض المركبات الجديدة بدءاً من 2-استيل فلورين و بارا فينيلين دي أمين حيث تم تحضير أساس شيف جديد المركب (1) بدءاً من (2-أستيل الفلورين/ بارا فنيلين دي أمين) عبر تفاعل التكاثف، ثم حضر صباغ آزو ميتين فلوريني المركب (2) و نتج عنه أساس شيف جديد المركب (3) بدءاً من أساس شيف المحضر سابقاً من خلال تفاعل تكاثف بين أساس شيف و 5،2- ثنائي هيدروكسي بنز ألدهيد. حضرنا أساس شيف جديد المركب (4) بدءاً من (أساس شيف المحضر سابقاً المركب (1) و 5،2- ثنائي هيدروكسي بنز ألدهيد) عبر تفاعل التكاثف. ثم حضرنا مشتقات فلورينية جديدة لحلقة β-اللاكتام المركب (5) و لحلقة التيازوليدينون-4 المركب (6) بدءاً من أساس شيف المحضر سابقاً المركب (4) مع كل من كلورو أستيل كلورايد و مركبتو حمض الخل على الترتيب عبر تفاعلات التحلق.
Aseries of Schiff base and their derivative (fluorene) have been synthesized primary amines was condensed with 2-acetyl fluorene in DMF (dimethyl formamide) in the presence of conc. HCl acid as catalyst to yield the Schiff base (1). The Schiff base (2,3) and (4) were prepared from the reaction of Schiff base (1) with 2-hydroxy-5-methyl-1,3- benzenedicarboxaldehyde and 2,5-dihydroxy benzaldehyde respectively. and The Schiff’s base (4) was treated with monochloroacetyl choride to give 1- substituted-4(2-fluorenyl)-3- chloro Azolidine-2-on (5).
References used
Salam. J. J. Titnchi, Fadhil. S. Kamounah, Hanna. S. Abbo, and ole Hammerich, "the synthesis of mano – and diacetyl -, H- fluorenes. Reactivity and selectivity in the lewis acid catalyzed Friedel –Grafts acetylation of, H-fluorine", arkivoc, 2008, Xiii, 91-105
Helmut. G. Alt, Syriac. J. Palackal, "fluorine – coumpounds", United States Patent, USOO, 5, 210, 352A, 1993
Ping Shanlai., (2007)- "Directed Ortho metalation – Boronation Suzuki – Miyaura cross coupling leading to syn thesis of Azafluorenol core liquid crystals". A thesis for the degree of science. Queen's university. Cansda
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The following imines: 1.8.13.20-tetraaza-13.3.6.18-diphenyl cyclotetracosan-
1.8.13.19- tetraene and butyradamantine, N.N’-di (admantyl) terephthimine
and 1.5.14.18-tetraaza-2.4.15.17-tetramethylcyclotetracosan-1.8.13.19- tetraene
based on dicarbonyl and amines were synthesized by reaction of dicarbonyl
compounds and different amines. The imines have been characterized by EA
(elemental analyses), IR, 1H- NMR and 13C-NMR.
We have synthesized some new compounds from 2-Acetyl Fluorene\ Thiophene
2-carbaldehyde chalcone via condensation and cyclization reactions between the chalcone and each of thiourea and urea, hydroxylamine hydrochloride and hydrazine hydrate, these
reactions afford these compounds:
3-(2-fluorenyl)-5-(2-thienyl) pyrazoline(4), 3-(2-fluorenyl)-5-(2-thienyl) Isoxazoline(3), 4-(2-fluorenyl)-6-(2-thienyl) pyrimidinone-2 (2) and 4-(2-fluorenyl)-6-(2-thienyl) pyrimidine-2 tione (1). Also 3-(2-fluorenyl)-5-(2-thienyl) isoxazole (5), were prepared via bromination of chalcon and cyclization the later with hydroxylamine hydrochloride.
Identification and determination of compounds structurs were carried out by (IR,
1H-NMR, 13C-NMR, LC-MS) spectrum Analysis.
Separation with solvent extraction of Cu(II), Hg(II), and Cr(III) from
aqueous solution using the ligend (HL) as a new extractant has been studied.
The new acyclic Schiff Base (HL) was synthesized by reaction of 5-bromosalicylaldehyde
with 2-(2-Am
inoethyl)pyridine. The structure of the new
compound (HL) was confirmed by using FT-IR spectra, 1H-NMR and 13CNMR
spectra and mass spectra (MS). The effect of chloroform and
dichloromethan as organic solvents in the metal extractions was investigated at
20oC by using UV-visible Spectrometry. The influence of pH, ligand
concentration, shaking time and ratio of aqueous-to-organic phases on
extraction yield was tested at 20oC. The extractability of the tested metal ions
were evaluated.
A new acyclic Schiff Base(II), containing nitrogen-oxygen donor atoms was
synthesized by reaction of 1,2-Bis (5-bromo-2-formyl-phenoxy) ethane with 2-
(2-Aminoethyl)pyridine and characterized. The liquid-liquid extraction of
transition metals such
as Cu+2, Cr+3 and Uranyl-picrate (UO2)+2 from aqueous
phase to the organic phase was carried out using the novel ligand. The effect of
chloroform and nitrobenzene as organic solvents on the metal extractions was
investigated at 20oC by using Atomic Absorption and UV-visible
Spectrophotometry. The influence of pH, ligand concentration, ionic strength,
shaking time and ratio of aqueous-to-organic phases on extraction yield was
tested at 20oC. The extractability of the tested metal ions were valuated.
The antibacterial activity of Golden henbane (Hyoscyamus aureus) on
several species of bacteria: Pseudomonas aeruginosa, Staphylococcus
aureus and Escherichia coli was determined. Samples of H. aureus
plants were collected from six locations in southern Syria. The extract
of roots and leaves of H. aureus were prepared at concentrations.
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