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Register a new userIsolation of Streptomyces sp. with antibacterial activity against some human pathogenic bacteria from soils of Lattakia city
عزل جرثوم المتسلسلة Streptomyces sp يمتلك خصائص مضادة لبعض الجراثيم الممرضة البشرية من ترب مدينة اللاذقية
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Aِl-Baath University ورقة بحثية
Publication date
2016
fields
Biology
and research's language is
العربية
Authors
أسمهان زينب( باحث )
Created by
Shamra Editor
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تم الحصول على أربع عزلات لجراثيم Streptomyces sp و هي : St.1 و St.2 من تربة حديقة كلية العلوم, و St.3 و St.4 من تربة منطقة الشامية, بطريقة التخفيف على وسط Starch Casein Agarّ.
Four isolates of Streptomyces sp., St.1 and St.2 were isolated from garden soil of science faculty, St.3 and St.4 were isolated from Al-Shameia soil Lattakia, by serial dilution on Starch Casein Agar medium.
Artificial intelligence review:
Research summary
تناولت الدراسة عزل أربع عزلات من جراثيم Streptomyces sp من تربتين مختلفتين في مدينة اللاذقية، سوريا. تم تقييم فعالية هذه العزلات ضد تسعة أنواع من الجراثيم الممرضة البشرية باستخدام طريقة الزراعة المتعامدة. أظهرت العزلة St.3 فعالية عالية ضد ثمانية أنواع من الجراثيم الممرضة، وتم تحديدها على أنها Streptomyces rimosus بناءً على الخصائص المورفولوجية والفيزيولوجية والكيميائية الحيوية. أظهرت العزلات الأخرى فعالية متفاوتة ضد الجراثيم الممرضة. أكدت النتائج أن التربة تحتوي على جراثيم Streptomyces التي يمكن أن تكون مصدرًا لاكتشاف مضادات حيوية جديدة.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة في مجال البحث عن مضادات حيوية جديدة، خاصة في ظل تزايد مقاومة الجراثيم للمضادات الحيوية التقليدية. ومع ذلك، يمكن توجيه بعض النقد البناء للدراسة. أولاً، كان من الممكن توسيع نطاق العينات المأخوذة من مواقع مختلفة للحصول على نتائج أكثر شمولية. ثانيًا، لم يتم التطرق بشكل كافٍ إلى الآليات الجزيئية التي تجعل العزلة St.3 فعالة ضد الجراثيم الممرضة، مما يفتح الباب لمزيد من الأبحاث المستقبلية. أخيرًا، كان من الممكن تضمين تجارب إضافية لتقييم سلامة وفعالية المركبات المستخلصة في النماذج الحيوانية قبل الانتقال إلى الدراسات السريرية.
Questions related to the research
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ما هي العزلة التي أظهرت أعلى فعالية ضد الجراثيم الممرضة البشرية؟
العزلة St.3 أظهرت أعلى فعالية ضد الجراثيم الممرضة البشرية بنسبة 88.88%.
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ما هي الأنواع الجرثومية التي لم تتأثر بالعزلة St.3؟
الجرثومة Acinetobacter sp لم تتأثر بالعزلة St.3.
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ما هو الهدف الرئيسي من الدراسة؟
الهدف الرئيسي هو عزل جراثيم Streptomyces من التربة ودراسة خصائصها المضادة للجراثيم الممرضة البشرية.
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ما هي التوصيات التي قدمتها الدراسة لمزيد من الأبحاث؟
التوصيات تشمل استخلاص المواد الفعالة من جراثيم Streptomyces rimosus ودراسة تأثيرها على أنواع جرثومية ممرضة أخرى، وإجراء أبحاث مستفيضة حول قدرة هذه الجراثيم على إنتاج المضادات الحيوية.
References used
ANANSIRIWATTANA W.; TANASUPAWAT S.; AMNUOYPOL S. and SUWANBORIRUX K. 2006, Identification and antimicrobial activities of actinomycetes from soils in Samed Island, and geldanamycin from strain PC4 – 3. Thia. J. Pharm. Sci., Vol. 30, pp. 49-56
ARAI, T. 1976, Actinomycetes, the boundary Microorganisms. Toppan, Tokyo, 123p
ARIFUZZAMAN M.; KHATUN M. R. and RAHMAN H. 2010, Isolation and screening of actinomycetes from Sundarbans soil for antibacterial activity. African Journal of Biotechnology, Vol. 9, No. 29, pp. 4615-4619
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Res
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