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Register a new userPruritus: a useful sign for predicting the red man syndrome following administration of vancomycin
الحكة: علامة مفيدة للتنبوء بمتلازمة الرجل الأحمر التالية لحقن الفانكومايسين
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Aِl-Baath University ورقة بحثية
Publication date
2016
fields
Medicine
and research's language is
العربية
Authors
فؤاد الخضر( باحث )
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Shamra Editor
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يمكن للفانكومايسين أن يسبب نمطين من تفاعلات فرط الحساسية هما متلازمة الرجل الأحمر و التآق. و غالباً ما تترافق متلازمة الرجل الأحمر مع التسريب الوريدي السريع للجرعة الأولى من الدواء. الهدف من هذه الدراسة هو استقصاء التبدلات الديناميكية الدموية التي تلي ظهور الحكة أثناء تسريب الفانكومايسين و حدوث متلازمة الرجل الأحمر. تمت دراسة 50 مريض تقرر لهم إجراء جراحة مجازات إكليلية، و تمت مقارنة المعطيات عند المرضى الذين ظهرت لديهم الحكة مع زملاؤهم الذين لم يعانوا منها. قبل البدء بتخدير المرضى تم تسريب الفانكومايسين بمعدل 15 ملغ/كغ بشكل ثابت خلال 30 دقيقة، و تم تسجيل التبدلات الدينامكية الدموية في فواصل زمنية قبل و أثناء و بعد حقن الفانكومايسين.
Vancomycin can cause two types of hypersensitivity reactions, the red man syndrome and anaphylaxis. Red man syndrome has often been associated with rapid infusion of the first dose of the drug. The aim of this study was to investigate the haemodynamic changes that follow the appearance of pruritus during vancomycin administration and development of red man syndrome. We studied 50 patients scheduled for coronary artery bypass surgery, and we compared data from patients who exhibited pruritus with those from patients who did not. Before induction of anaesthesia, vancomycin (15 mg/kg) was continuously infused at a constant rate over 30 min. Haemodynamic profiles were recorded before; during and after the beginning of vancomycin infusion.
References used
Fekety R: Vancomycin and teicoplanin. In Principles and Practice of Infectious Disease. Edited by Mandell GL, Bennett JE, Dolin R. New York: Churchill Livingstone; 1995:346-354
Wilhelm MP, Estes L: Symposium on antimicrobial agents: vancomycin. Mayo Clin Proc 1999, 74:928-935
Wilhelm MP: Vancomycin. Mayo Clin Proc 1991, 66:1165- 1170
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Uremic Pruritus is one of the most common and frustrating symptom experience by patients with end-stage renal disease. Approximately 60% of dialysis patients experience pruritis, sometimes worse during the dialysis session.
The aim of this study w
as to determine the effect of gabapentin, 200 mg twice a week (after each hemodialysis session), on uremic pruritus.
Patients older than 18 years who have undergone hemodialysis for more than three months will be enrolled in this double-blind clinical trial.
The patients will be assigned to receive Gabapentin 200 mg following hemodialysis
( twice a week) for a period of four weeks, and after a washout week, they will receive the antihistamines for another four weeks.
The patients will be asked to evaluate the severity of their pruritus using a visual analogue scale (VAS).
Our results assured the efficacy of Gabapentin in the treatment of uremic pruritus, in comparison with Loratadine.
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Understanding and executing natural language instructions in a grounded domain is one of the hallmarks of artificial intelligence. In this paper, we focus on instruction understanding in the blocks world domain and investigate the language understand
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Aim:
To evaluate the hearing changes following stapedotomy surgery,
and to investigate the potential effects of the age and sex of the
patients on air-bone gap closure.
Material and Methods:
80 patients diagnosed with otosclerosis and undergone
stapedotomy surgery, were involved in this study. The hearing changes were evaluated by comparing the means of air and bone conductive measurements at 250-500-1000-2000 and 4000 Hz before and after surgery. In addition, the air-bone gap closure was determined. Data was analysed statistically using t-student and Anova tests (p=0.05).
Results:
There was a statistically significant difference in air conductive
measurements before and after surgery (p<0.001), whilst the bone
conductive values showed no differences. The mean of air-bone
closure in the current study was 28.6dB.
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