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Register a new userDetection of the Anti-inflammatory activity of Crataegus laevigata in rats with experimentally-induced arthritis
الكشف عن الفعالية المضادة للالتهاب لخلاصة نبات الزعرور الحراجي على الجرذان المحدث لديها الالتهاب المفصلي تجريبياً
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Damascus University ورقة بحثية
Publication date
2015
fields
Pharmacy
and research's language is
العربية
Created by
Shamra Editor
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خلفية البحث و هدفه: أجري هذا البحث لاستقصاء الفعالية المضادة للالتهاب للخلاصة للبراعم الزهرية للزعرور الحراجي Crataegus laevigata لدى الجرذان المحدث لديها الالتهاب المفصلي تجريبياً. مواد البحث و طرائقه: حرض الالتهاب تجريبياً بمادة الكاراجينان Carrageenan التي تعد مادة معيارية تتسبب في نموذجٍ تجريبي للالتهاب الحاد غير المناعي. و قِيس حجم الوذمة قبل تحريض الالتهاب و بعده، في مجموعة الشاهد فضلاً عن المجموعة المعالجة بالخلاصة وب مادة الديكلوفيناك. و استمر القياس حتى الساعة الرابعة التالية لحقن الكاراجينان. وفي مجموعة أخرى من التجارب عوِير الواصم الحيوي المهم TNF-α لدى مجموعة الجرذان المحرض لديها الالتهاب التي تلقت الخلاصة أو الديكلوفيناك و قورنت بالشاهد. النتائج: حققت الخلاصة النباتية انخفاضاً معتداً به في حجم الوذمة بالمقارنة بالشاهد. و كان هذا التأثير لا يقل عن تأثير الديكلوفيناك الدواء المعياري المضاد للالتهاب، و في الواقع خفضت الخلاصة TNF-α . الاستنتاج: تملك خلاصة الزعرور الكحولية تأثيراً واضحاً مضاداً للالتهاب، لكن ينبغي أن يستقصى هذا التأثير بشكل أعمق.
Background& Objective: This research is carried out to investigate the Anti-inflammatory activity of the alcoholic extract of flower buds of Crataegus laevigata in experimentally-induced arthritis in rats. Materials & Methods: the inflammation was induced experimentally by Carrageenan, the standard material that causes non-immune acute inflammation. The size of edema was measured before and after the inducing the inflammation, in control group as well as in group treated by extract and by Diclofenac. The measurements persist until the 4th hour following the injection of Carrageenan. In another set of experiment, the important biomarker, TNF-α, was calibrated in inflammation-induced groups of rats that received extract or Diclofenac and compared with control. Results: The extract significantly reduced the size of edema compared with control and this effect was not less than that of Diclofenac, the standard anti-inflammatory drug. Indeed, the extract lowered the values of TNF-α. Conclusion: The Crataegus laevigata has clear anti-inflammatony effect , but it should be further investigated.
References used
Tassel, M.C., Kingston, R., Gilroy, D., Lehane, M.,Furey, A. Hawthorn (Crataegus spp.) in the treatment of cardiovascular disease. Pharmcogn. Rev. 2010, 4, 32–41
Kirakosyan A., Seymour E., Kaufman PB., Warber S., Antioxidant capacity of polyphenoloc extracts from leaves of Crataegus laevigata and C. monogyna (hawthorn) subjected to drought and cold stress. 2003 ,51, 3973– 3976
Tunde Jurikova, Jiri Sochor, Otakar Rop, Polyphenolic Profile and Biological Activity of Chinese Hawthorn Molecules 2012, 17, 14490-14509
Edwards JE, Brown PN, Talent N, Dickinson TA, Shipley PR. A review of the chemistry of the genus Crataegus. Phytochemistry., 2012 Jul;79:5-26
Liu P, Kallio H, Yang B. Phenolic compounds in hawthorn (Crataegus grayana) fruits and leaves and changes during fruit ripening. J Agric Food Chem.,2011 Oct 26;59(20):11141-9
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