تُعد السرطانة (الكارسينوما) قاعدية الخلايا (BCC) من أكثر الأورام الخبيثة شيوعاً عند الكهـول
ذوي البشرة الفاتحة. و التي تتصف بأنها يمكن أن تؤدي لعقابيل شديدة من خلال النكس و التخريب
الموضعي، إِذْ إن أكثر من ٧٥٠٠٠٠ حالة جديدة تسجل كل عام في العالم مع تأكيـدات بوجـود
زيادة سنوية في نسبة الحدوث، إلا أنه حسب معرفتنا فإن معلومات دقيقة عن هذه السرطانة فـي
المجتمع السوري ضئيلة.
Basal cell carcinoma (BCC) is the commonest cancer in fair-skinned adults, and
it can result in extensive morbidity through local recurrence and destruction
more than 750000 new cases are diagnosed in the world annually, and the
incidence is rising.
To our knowledge, a distinct information about BCC in Syrian population is
scarce.
This study was performed in dermatology hospital of the university of Damascus
between 1-1-1997 and 1-1-1999. A total of 255 cases of histologically-confirmed
BCC 's were studied.
Our results showed the most significant characteristics of BCC in Syria: 67.1% of
patients were men, while 32.9% were women. The median age was 58.9. the part
most frequently involved was the central face (45.5%), while the trunk and
extremities were involved in (7%). Multiple BCC was found in 7.7%.
The most common histologic types of BCC were: circumscribed solid (45.4%),
adenoid (13.3%), and invasive solid (12.5%).
References used
Betti-R; Bruscagin - C; and all. Bacal cell Carcinoma of of covered and unusual sites of the body Int- J- Dermatol. 1997 July; 36 (7): 503-5
Elder-D; Elenitsas-R; and all. Lever’s histopathology of the skin. 8th ed
English - DR; Kricker - A; and all . Incidence of non- melanocytic skin cancer in Western Australia. Int-J- cancer, 1997 Nov 27,73 (5); 626-33
This is the case of male aged 57 years old who had a squamous cell carcinoma,clear cell type, of iliaclocation. He previously had clear cell SCC in the laryux.
cancers (include oral cancers) endanger the human life so they
must be detected, diagnosis early and avoided. More than 90% of these oral
malignancies are squamous cell carcinomas. The prognosis for these
malignancies continues to be poor with approximately 50%survival at five
years.
This retrospective study is to correlate oral squamous cell carcinoma with age,
gender and location of lesion, and to investigate the correlation between the grade of the malignancy and
lymph nodes in patients of the faculty of dentistry, Damascus university.
Aim of study: study of the differences in the protein expression of
Cyclin-dependent Kinase CdK1, CdK2 in Oral Squamous Cell
Carcinoma (OSCC) and in clinically- normal oral mucosa.
The protein p53 is the guardian of the cell gene contents from changes, and the
gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell
carcinoma’s cases producing defective protein .Studies have not detailed the