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Register a new userClear Cell Squamous Cell Carcinoma
الكارسينوما شائكة الخلايا ذات خلايا رائقة
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هذه الحالة لذكر عمره 57 عاماً لديه حالة نادرة من سرطانة شائكة الخلايا النمط الرائق في الإلية، و في سوابقه استئصال حنجرة فيها سرطانة شائكة الخلايا من النمط الرائق أيضاً.
This is the case of male aged 57 years old who had a squamous cell carcinoma,clear cell type, of iliaclocation. He previously had clear cell SCC in the laryux.
References used
Philip E. LeBoit,Günter Burg,David Weedon ,Alain Sarasin (2006) WHO Pathology and Genetics of Skin Tumours. IARCPress , Lyon ,France
Juan Rosai (2004) Rosai and ackerman’s surgical pathology. Elsevier Inc., Philadelphia, USA
Leon Barnes, John W. Eveson, Peter Reichart, David Sidransky (2005) WHO Pathology and Genetics of Head and Neck Tumours . IARCPress, Lyon, France
.William D. Travis, Elisabeth Brambilla, H. Konrad Müller-Hermelink, Curtis C. Harris (2004) WHO Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart . IARCPress , Lyon,France
Medscape news today: http://www.medscape.com/viewarticle/409063_10 Histologic Variants of Squamous Cell Carcinoma of the Skin: Clear Cell Squamous Cell Carcinoma
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cancers (include oral cancers) endanger the human life so they
must be detected, diagnosis early and avoided. More than 90% of these oral
malignancies are squamous cell carcinomas. The prognosis for these
malignancies continues to be poor with approximately 50%survival at five
years.
الموت الخلوي المبرمج
الكينازات مرتبطة بالسيكلين
الجينة Cyclin D
السرطان الفموي
سرطان شائك الخلايا
التلوين بالكيمياء النسيجية المناعية
الجينة السرطانية
programmed cell death
Oral Cancer
Cyclindependent kinase
Squamous cell carcinomas
Oncogenes of Cell Cycle Control
Immunohistochemically
oncogene
المزيد..
Basal cell carcinoma (BCC) is the commonest cancer in fair-skinned adults, and
it can result in extensive morbidity through local recurrence and destruction
more than 750000 new cases are diagnosed in the world annually, and the
incidence is risin
g.
To our knowledge, a distinct information about BCC in Syrian population is
scarce.
This study was performed in dermatology hospital of the university of Damascus
between 1-1-1997 and 1-1-1999. A total of 255 cases of histologically-confirmed
BCC 's were studied.
Our results showed the most significant characteristics of BCC in Syria: 67.1% of
patients were men, while 32.9% were women. The median age was 58.9. the part
most frequently involved was the central face (45.5%), while the trunk and
extremities were involved in (7%). Multiple BCC was found in 7.7%.
The most common histologic types of BCC were: circumscribed solid (45.4%),
adenoid (13.3%), and invasive solid (12.5%).
Aim of study: study of the differences in the protein expression of
Cyclin-dependent Kinase CdK1, CdK2 in Oral Squamous Cell
Carcinoma (OSCC) and in clinically- normal oral mucosa.
The protein p53 is the guardian of the cell gene contents from changes, and the
gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell
carcinoma’s cases producing defective protein .Studies have not detailed the
expression ratio of the
defective protein Within the cancer cells, also studies have less details about the cases which did not show
a mutated protein.
This retrospective study is to correlate oral squamous cell carcinoma with age,
gender and location of lesion, and to investigate the correlation between the grade of the malignancy and
lymph nodes in patients of the faculty of dentistry, Damascus university.
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