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The Role of Helicobacter Pylori in Gastritis and Gastroduodenitis in Children

دور الملتوية البوابية في أمراض المعدة و العفج لدى الأطفال

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 Publication date 2005
and research's language is العربية
 Created by Shamra Editor




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The aim of this study is to determine the incidence of helicobacter pylori (HP) in patients with chronic gastroduodenitis and to compare the clinical presentations between patients with positive HP chronic gastroduodenitis and those with negative HP. Also, To compare the endoscopic findings between patients with HP positive gastroduodenitis and HP negative children. Gastroduodenoscopy was done for every child with abdominal pain admitted at the children hospital-Damascus University between 2002-2003. Mucosal biopsy was taken from every patient who had gastroduodenitis diagnosed by gastroduodenoscopy. The percentage of patients with gastroduodenitis having HP positive erosions was 48.38 %. Higher percentage of HP positive patient was more present in those with the erosion and sub-atrophy forms.


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Research summary
تهدف هذه الدراسة إلى تحديد نسبة حدوث بكتيريا هيليكوباكتر بيلوري (HP) في المرضى الذين يعانون من التهاب المعدة والاثني عشر المزمن، ومقارنة الأعراض السريرية بين المرضى الذين يعانون من التهاب المعدة والاثني عشر المزمن مع HP إيجابي وأولئك الذين يعانون من HP سلبي. كما تهدف الدراسة إلى مقارنة النتائج التنظيرية بين الأطفال المصابين بالتهاب المعدة والاثني عشر مع HP إيجابي وأولئك الذين يعانون من HP سلبي. تم إجراء تنظير المعدة والاثني عشر لكل طفل يعاني من آلام في البطن تم قبوله في مستشفى الأطفال بجامعة دمشق بين عامي 2002-2003. وتم أخذ خزعة من الغشاء المخاطي لكل مريض تم تشخيصه بالتهاب المعدة والاثني عشر بواسطة التنظير. أظهرت النتائج أن نسبة المرضى الذين يعانون من التهاب المعدة والاثني عشر ولديهم HP إيجابي كانت 48.38%. كانت نسبة أعلى من المرضى الذين يعانون من HP إيجابي موجودة في أولئك الذين يعانون من التآكل والتهاب تحت الضمور. تم العثور على التهاب تحت الضمور في 7 من أصل 15 مريضًا HP إيجابي (46.66%)، في حين تم العثور على التهاب سطحي في 14 من أصل 16 مريضًا HP سلبي (87.50%). أظهرت الدراسة أن هناك فرقًا كبيرًا في النتائج التنظيرية بين المرضى الذين يعانون من HP إيجابي وأولئك الذين يعانون من HP سلبي. قد تساعد هذه النتائج الأطباء في تجنب أخذ الخزعات غير الضرورية، مما يقلل من تكلفة الإجراء.
Critical review
دراسة نقدية: تقدم هذه الدراسة نظرة شاملة على دور بكتيريا هيليكوباكتر بيلوري في التهاب المعدة والاثني عشر لدى الأطفال، وتساهم في فهم الفروقات بين المرضى الذين يعانون من HP إيجابي وأولئك الذين يعانون من HP سلبي. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الممكن أن تكون الدراسة أكثر شمولاً إذا تضمنت عينة أكبر من المرضى، مما يزيد من قوة النتائج. ثانيًا، لم يتم التطرق بشكل كافٍ إلى العوامل المحتملة الأخرى التي قد تؤثر على النتائج، مثل العوامل البيئية أو الوراثية. أخيرًا، كان من الممكن أن تكون الدراسة أكثر فائدة إذا تم تضمين توصيات عملية للأطباء بناءً على النتائج المستخلصة.
Questions related to the research
  1. ما هي نسبة المرضى الذين يعانون من التهاب المعدة والاثني عشر ولديهم HP إيجابي؟

    نسبة المرضى الذين يعانون من التهاب المعدة والاثني عشر ولديهم HP إيجابي هي 48.38%.

  2. ما هي الأعراض السريرية الأكثر شيوعًا لدى المرضى الذين يعانون من HP إيجابي؟

    الأعراض السريرية الأكثر شيوعًا لدى المرضى الذين يعانون من HP إيجابي هي آلام البطن (93.33%) ومتلازمة عسر الهضم (80.00%).

  3. هل هناك فرق في النتائج التنظيرية بين المرضى الذين يعانون من HP إيجابي وأولئك الذين يعانون من HP سلبي؟

    نعم، هناك فرق كبير في النتائج التنظيرية بين المرضى الذين يعانون من HP إيجابي وأولئك الذين يعانون من HP سلبي.

  4. كيف يمكن أن تساعد نتائج هذه الدراسة الأطباء في تقليل تكلفة الإجراءات الطبية؟

    يمكن أن تساعد نتائج هذه الدراسة الأطباء في تجنب أخذ الخزعات غير الضرورية، مما يقلل من تكلفة الإجراءات الطبية.


References used
Anderson L.p., Holck .S., Paulsen C.O. Campylobacter pyloridis in peptic ulcer disease . 1: Gastric and duodenal infection caused by C. pyloridis. 2: Histophathologic and microbiologic findings // Scand.J. Gastroenterol .- 1987 . – Vol .22- P. 219-224
Andreasen J.J. Andersen L.P. In vitro susceptibility of Campylobacter pyloridis to cimetidine , sucralfate , bismuth and sixteen antibiotics // Acta path . Microbiol . Scand – 1987- Vol. 95, N 2 – P. 147 – 149
Arived A.S. , Cook R.S., Tabagchalis . One – minute endoscopy room test for Campylobacter pylorid // Lancet . – 1988 . – Vol . 1, N 8587 . P. 704
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