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The role of measurement of IgE in blood of umbilical cord in predicting allergic diseases in children

دور معايرة IgE دم الحبل السري في التنبؤ عن حدوث أمراض تحسسية عند الأطفال

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 Publication date 2013
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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The study included 143 children from 214 newborn with high umbilical cord blood IgE (UC – IgE) at birth: more than 0.5 international unit per ml. We followed up these children from birth for 8 years. We found positive atopic familial history by 51.7 % from study samples, against negative history by 48.3% . During control duration atopic diseases were developed by 76.22 % of children with high UC – IgE, against 23.8 % without atopic diseases. These children with atopic different disorders suffered from allergic rhinitis 19.6 % , allergic skin disorders (eczema, urticaria) 25.2 % and asthma 31.5% . The rate of atopic diseases development was 51.7% in children with high UC-IgE, and positive history together, while only 24.5 % in children with high UC-IgE with negative familial history.


Artificial intelligence review:
Research summary
تناولت الدراسة دور معايرة IgE في دم الحبل السري في التنبؤ بحدوث الأمراض التحسسية عند الأطفال. شملت الدراسة 143 طفلاً من أصل 214 مولوداً ذوي IgE مرتفع، وتمت متابعتهم لمدة 8 سنوات. أظهرت النتائج أن 76.22% من الأطفال ذوي IgE مرتفع تطورت لديهم أمراض تحسسية مقارنة بـ 23.8% لم تظهر لديهم أعراض تحسسية. كما تبين أن القصة العائلية التحسسية الإيجابية تزيد من احتمالية تطور الأمراض التحسسية، حيث بلغت نسبة تطور الأمراض التحسسية 51.78% عند اجتماع العاملين (القصة العائلية + ارتفاع IgE) مقارنة بـ 24.5% عند الأطفال ذوي IgE مرتفع وقصة عائلية سلبية. توزعت الأمراض التحسسية بين تحسس أنفي (19.6%)، تحسس جلدي (25.2%)، وربو طفولي (31.5%). أكدت الدراسة على أهمية معايرة IgE في دم الحبل السري كعامل تنبؤي للأمراض التحسسية وضرورة اتخاذ إجراءات وقائية مبكرة للأطفال المعرضين للخطر.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في مجال البحث الطبي حول التنبؤ بالأمراض التحسسية عند الأطفال. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة قد يكون غير كافٍ لتعميم النتائج على نطاق أوسع. ثانياً، لم يتم تناول العوامل البيئية التي قد تؤثر على تطور الأمراض التحسسية بشكل كافٍ. ثالثاً، كان من الممكن أن تكون فترة المتابعة أطول لتقديم نتائج أكثر دقة وشمولية. على الرغم من هذه النقاط، فإن الدراسة تقدم إسهاماً مهماً في فهم العلاقة بين IgE في دم الحبل السري وتطور الأمراض التحسسية.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو تحديد دور معايرة IgE في دم الحبل السري في التنبؤ بحدوث الأمراض التحسسية عند الأطفال.

  2. ما هي نسبة الأطفال الذين تطورت لديهم أمراض تحسسية في حال اجتماع القصة العائلية الإيجابية وارتفاع IgE دم الحبل السري؟

    نسبة تطور الأمراض التحسسية بلغت 51.78% عند اجتماع القصة العائلية الإيجابية وارتفاع IgE دم الحبل السري.

  3. ما هي الأمراض التحسسية الأكثر شيوعاً التي ظهرت لدى الأطفال في الدراسة؟

    الأمراض التحسسية الأكثر شيوعاً كانت الربو الطفولي (31.5%)، التحسس الجلدي (25.2%)، والتحسس الأنفي (19.6%).

  4. ما هي التوصيات التي خرجت بها الدراسة؟

    توصي الدراسة بإجراء معايرة IgE دم الحبل السري عند الولدان ذوي القصة العائلية التحسسية الإيجابية واتخاذ إجراءات وقائية مبكرة مثل الإرضاع الوالدي ومنع التدخين في محيط الطفل.


References used
MIRIAM ; JOHN, M . Hypersensitivity Reactions Immediate . emedicine specialties . 2004
BEHRMAN, R ; KLEIGMAN, R ; JENSON, H. Nelson Textbook of Pediatrics, 17th Edition , W.B.SAUNERS COMPANY , U .S .A , 2004 , 743-774
ALLAM, J.P ; ZIVANOVIC, O ; BERG, C ; GEMBRUCH, U ; BIEBER, T ; NOVAK, N .N . Search For Prediction Factors For Atopy in Human Cord Blood . Allergy . 2005 . Vol 60 , 743-750
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