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Register a new userThe role of measurement of IgE in blood of umbilical cord in predicting allergic diseases in children
دور معايرة IgE دم الحبل السري في التنبؤ عن حدوث أمراض تحسسية عند الأطفال
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Tishreen University ورقة بحثية
Publication date
2013
fields
Medicine
and research's language is
العربية
Authors
غزل ديب( باحث )
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Shamra Editor
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شملت الدراسة 143 طفلاً كان عيار IgE دم الحبل السري لديهم عند الولادة مرتفعاً أكثر من 0.5 وحدة دولية/مل من أصل 214 مولوداً ذوي IgE و دم الحبل السري مرتفع و ذلك بمتابعتهم منذ الولادة حتى عمر 8 سنوات. تبين وجود قصة عائلية تحسسية إيجابية عند 51.7% من العينات المدروسة مقابل 48.3 % ذوي قصة عائلية سلبية. خلال فترة المراقبة (8 سنوات الأولى من العمر) تطوّر تحسس عند 76.22% من الأطفال الذين كان لديهم IgE دم الحبل السري مرتفعاً مقابل 23.8% لم تلاحظ لديهم أعراض تحسسية خلال هذه الفترة من المراقبة. تنوعت الأمراض التحسسية التي ظهرت لدى الأطفال المدروسين بين 19.6% تحسس أنفي، و 25.2% تحسس جلدي (أكزيما ، شري)، 31.5 % ربو طفولي. كانت نسبة تطور الأمراض التحسسية في حال اجتماع العاملين (القصة العائلية + ارتفاع IgE دم الحبل السري) 51.78 % مقابل 24.5 % عند الأطفال ذوي IgE مرتفع و قصة عائلية سلبية.
The study included 143 children from 214 newborn with high umbilical cord blood IgE (UC – IgE) at birth: more than 0.5 international unit per ml. We followed up these children from birth for 8 years. We found positive atopic familial history by 51.7 % from study samples, against negative history by 48.3% . During control duration atopic diseases were developed by 76.22 % of children with high UC – IgE, against 23.8 % without atopic diseases. These children with atopic different disorders suffered from allergic rhinitis 19.6 % , allergic skin disorders (eczema, urticaria) 25.2 % and asthma 31.5% . The rate of atopic diseases development was 51.7% in children with high UC-IgE, and positive history together, while only 24.5 % in children with high UC-IgE with negative familial history.
References used
MIRIAM ; JOHN, M . Hypersensitivity Reactions Immediate . emedicine specialties . 2004
BEHRMAN, R ; KLEIGMAN, R ; JENSON, H. Nelson Textbook of Pediatrics, 17th Edition , W.B.SAUNERS COMPANY , U .S .A , 2004 , 743-774
ALLAM, J.P ; ZIVANOVIC, O ; BERG, C ; GEMBRUCH, U ; BIEBER, T ; NOVAK, N .N . Search For Prediction Factors For Atopy in Human Cord Blood . Allergy . 2005 . Vol 60 , 743-750
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This research aims at establishing
and testing protocols for isolation, in vitro proliferation, phenotyping, and
differentiation of MSCs embedded in umbilical cord tissues of Syrian
newborns.
MSCs were isolated from two caesarian births depending
on their
adherence characteristic on plastic surfaces, and cells were cultured in MSC
medium for their growth and proliferation. Cell phenotyping was performed by
flow cytometry using fluorescent monoclonal antibodies specific to MSCs’
surface markers. Cultured cells were passed several times and a portion of
these cells was cryopreserved in liquid nitrogen, and cell viability was assessed.
Differentiation of these MSCs into adipocytes was conducted using culture
medium Indomethacin and hydrocortisone.
Stem cells have unique capability to differentiate into many cell types that can
normally replace the loss in some cells of the body due to tissue injury. Umbilical cord blood (UCB) and
umbilical cord (UC) are the two main sources for hematopoietic
stem cells (HSCs) and mesenchymal stem
cells (MSCs), respectively, which constitutes the basis for stem cell banks that have been established
worldwide and very recently in Syria. Research in our region has mainly focused on cell storage and
freezing protocols, and only few studies were conducted to prove the ability of the stored cells to
differentiate into their destined lineages. This study aimed to test the potential of cryopreserved MSCs
isolated from an umbilical cord taken from new delivery at Maternity University Hospital in Damascus, to
differentiate into various types of cells in response to growth and induction factors specific to cell lineages.
The aim of this study is to determine the incidence of helicobacter pylori
(HP) in patients with chronic gastroduodenitis and to compare the clinical
presentations between patients with positive HP chronic gastroduodenitis
and those with negative
HP. Also, To compare the endoscopic findings
between patients with HP positive gastroduodenitis and HP negative
children.
Gastroduodenoscopy was done for every child with abdominal pain
admitted at the children hospital-Damascus University between 2002-2003.
Mucosal biopsy was taken from every patient who had gastroduodenitis
diagnosed by gastroduodenoscopy.
The percentage of patients with gastroduodenitis having HP positive
erosions was 48.38 %.
Higher percentage of HP positive patient was more present in those with the
erosion and sub-atrophy forms.
The study aimed to demonstrate the importance of applying PH- METRY test in the diagnosis of gastroesophageal reflux disease(GERD) of children with recurrent respiratory diseases, to determine the most common digestive and other clinical symptoms(res
piratory) associated with GERD in the study . Thirty children with recurrent respiratory disease aged between two months and 11 years, were included in this study whom applied pH-Metry monitoring. GERD was found in 83.33% of children with recurrent respiratory disease, most patients(63.33%) were less than 3 years with the highest ratio of GERD( 89.4%). The cough was the most common of respiratory symptoms (90%). The prevalence rate of GERD between consenting patients was( 92%) .Night respiratory symptoms were found in (67%) of children. The prevalence rate of GERD between consenting patients was(68%) . Statistically significant relationship found between regurgitated vomiting and the presence of GERD (P = 0,043),and between the night digestive symptoms and GERD(P=0.009)
Hypertension is a common disease whose cardiac complications are very important sources of morbidity and mortality. These complications were detected by xray, electra car diography and echo cardiogeaphy.
We have 248 patients in our study: 140 male a
nd 108 female whose ages range between 34 and 80.
Our study shows that the common cardiac compliations are:
disorder of diastolic function (71%).
Diloted cardio my opathy25.8%.
Hy pertrophic cordiomiopathy.43.5%.
arrhythamias (29.8%).
coronary arteries disease 22.6%.
Studying the relationship between cardiac complications and treatment shows that the regular and sufficient treatment seduces the cardiac compilation of hyprtension.
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