Do you want to publish a course? Click here

The role of measurement of IgE in blood of umbilical cord in predicting allergic diseases in children

دور معايرة IgE دم الحبل السري في التنبؤ عن حدوث أمراض تحسسية عند الأطفال

1469   0   13   0 ( 0 )
 Publication date 2013
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




Ask ChatGPT about the research

The study included 143 children from 214 newborn with high umbilical cord blood IgE (UC – IgE) at birth: more than 0.5 international unit per ml. We followed up these children from birth for 8 years. We found positive atopic familial history by 51.7 % from study samples, against negative history by 48.3% . During control duration atopic diseases were developed by 76.22 % of children with high UC – IgE, against 23.8 % without atopic diseases. These children with atopic different disorders suffered from allergic rhinitis 19.6 % , allergic skin disorders (eczema, urticaria) 25.2 % and asthma 31.5% . The rate of atopic diseases development was 51.7% in children with high UC-IgE, and positive history together, while only 24.5 % in children with high UC-IgE with negative familial history.


Artificial intelligence review:
Research summary
تناولت الدراسة دور معايرة IgE في دم الحبل السري في التنبؤ بحدوث الأمراض التحسسية عند الأطفال. شملت الدراسة 143 طفلاً من أصل 214 مولوداً ذوي IgE مرتفع، وتمت متابعتهم لمدة 8 سنوات. أظهرت النتائج أن 76.22% من الأطفال ذوي IgE مرتفع تطورت لديهم أمراض تحسسية مقارنة بـ 23.8% لم تظهر لديهم أعراض تحسسية. كما تبين أن القصة العائلية التحسسية الإيجابية تزيد من احتمالية تطور الأمراض التحسسية، حيث بلغت نسبة تطور الأمراض التحسسية 51.78% عند اجتماع العاملين (القصة العائلية + ارتفاع IgE) مقارنة بـ 24.5% عند الأطفال ذوي IgE مرتفع وقصة عائلية سلبية. توزعت الأمراض التحسسية بين تحسس أنفي (19.6%)، تحسس جلدي (25.2%)، وربو طفولي (31.5%). أكدت الدراسة على أهمية معايرة IgE في دم الحبل السري كعامل تنبؤي للأمراض التحسسية وضرورة اتخاذ إجراءات وقائية مبكرة للأطفال المعرضين للخطر.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في مجال البحث الطبي حول التنبؤ بالأمراض التحسسية عند الأطفال. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة قد يكون غير كافٍ لتعميم النتائج على نطاق أوسع. ثانياً، لم يتم تناول العوامل البيئية التي قد تؤثر على تطور الأمراض التحسسية بشكل كافٍ. ثالثاً، كان من الممكن أن تكون فترة المتابعة أطول لتقديم نتائج أكثر دقة وشمولية. على الرغم من هذه النقاط، فإن الدراسة تقدم إسهاماً مهماً في فهم العلاقة بين IgE في دم الحبل السري وتطور الأمراض التحسسية.
Questions related to the research
  1. ما هو الهدف الرئيسي من الدراسة؟

    الهدف الرئيسي من الدراسة هو تحديد دور معايرة IgE في دم الحبل السري في التنبؤ بحدوث الأمراض التحسسية عند الأطفال.

  2. ما هي نسبة الأطفال الذين تطورت لديهم أمراض تحسسية في حال اجتماع القصة العائلية الإيجابية وارتفاع IgE دم الحبل السري؟

    نسبة تطور الأمراض التحسسية بلغت 51.78% عند اجتماع القصة العائلية الإيجابية وارتفاع IgE دم الحبل السري.

  3. ما هي الأمراض التحسسية الأكثر شيوعاً التي ظهرت لدى الأطفال في الدراسة؟

    الأمراض التحسسية الأكثر شيوعاً كانت الربو الطفولي (31.5%)، التحسس الجلدي (25.2%)، والتحسس الأنفي (19.6%).

  4. ما هي التوصيات التي خرجت بها الدراسة؟

    توصي الدراسة بإجراء معايرة IgE دم الحبل السري عند الولدان ذوي القصة العائلية التحسسية الإيجابية واتخاذ إجراءات وقائية مبكرة مثل الإرضاع الوالدي ومنع التدخين في محيط الطفل.


References used
MIRIAM ; JOHN, M . Hypersensitivity Reactions Immediate . emedicine specialties . 2004
BEHRMAN, R ; KLEIGMAN, R ; JENSON, H. Nelson Textbook of Pediatrics, 17th Edition , W.B.SAUNERS COMPANY , U .S .A , 2004 , 743-774
ALLAM, J.P ; ZIVANOVIC, O ; BERG, C ; GEMBRUCH, U ; BIEBER, T ; NOVAK, N .N . Search For Prediction Factors For Atopy in Human Cord Blood . Allergy . 2005 . Vol 60 , 743-750
rate research

Read More

This research aims at establishing and testing protocols for isolation, in vitro proliferation, phenotyping, and differentiation of MSCs embedded in umbilical cord tissues of Syrian newborns. MSCs were isolated from two caesarian births depending on their adherence characteristic on plastic surfaces, and cells were cultured in MSC medium for their growth and proliferation. Cell phenotyping was performed by flow cytometry using fluorescent monoclonal antibodies specific to MSCs’ surface markers. Cultured cells were passed several times and a portion of these cells was cryopreserved in liquid nitrogen, and cell viability was assessed. Differentiation of these MSCs into adipocytes was conducted using culture medium Indomethacin and hydrocortisone.
Stem cells have unique capability to differentiate into many cell types that can normally replace the loss in some cells of the body due to tissue injury. Umbilical cord blood (UCB) and umbilical cord (UC) are the two main sources for hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs), respectively, which constitutes the basis for stem cell banks that have been established worldwide and very recently in Syria. Research in our region has mainly focused on cell storage and freezing protocols, and only few studies were conducted to prove the ability of the stored cells to differentiate into their destined lineages. This study aimed to test the potential of cryopreserved MSCs isolated from an umbilical cord taken from new delivery at Maternity University Hospital in Damascus, to differentiate into various types of cells in response to growth and induction factors specific to cell lineages.
The aim of this study is to determine the incidence of helicobacter pylori (HP) in patients with chronic gastroduodenitis and to compare the clinical presentations between patients with positive HP chronic gastroduodenitis and those with negative HP. Also, To compare the endoscopic findings between patients with HP positive gastroduodenitis and HP negative children. Gastroduodenoscopy was done for every child with abdominal pain admitted at the children hospital-Damascus University between 2002-2003. Mucosal biopsy was taken from every patient who had gastroduodenitis diagnosed by gastroduodenoscopy. The percentage of patients with gastroduodenitis having HP positive erosions was 48.38 %. Higher percentage of HP positive patient was more present in those with the erosion and sub-atrophy forms.
The study aimed to demonstrate the importance of applying PH- METRY test in the diagnosis of gastroesophageal reflux disease(GERD) of children with recurrent respiratory diseases, to determine the most common digestive and other clinical symptoms(res piratory) associated with GERD in the study . Thirty children with recurrent respiratory disease aged between two months and 11 years, were included in this study whom applied pH-Metry monitoring. GERD was found in 83.33% of children with recurrent respiratory disease, most patients(63.33%) were less than 3 years with the highest ratio of GERD( 89.4%). The cough was the most common of respiratory symptoms (90%). The prevalence rate of GERD between consenting patients was( 92%) .Night respiratory symptoms were found in (67%) of children. The prevalence rate of GERD between consenting patients was(68%) . Statistically significant relationship found between regurgitated vomiting and the presence of GERD (P = 0,043),and between the night digestive symptoms and GERD(P=0.009)
Hypertension is a common disease whose cardiac complications are very important sources of morbidity and mortality. These complications were detected by xray, electra car diography and echo cardiogeaphy. We have 248 patients in our study: 140 male a nd 108 female whose ages range between 34 and 80. Our study shows that the common cardiac compliations are: disorder of diastolic function (71%). Diloted cardio my opathy25.8%. Hy pertrophic cordiomiopathy.43.5%. arrhythamias (29.8%). coronary arteries disease 22.6%. Studying the relationship between cardiac complications and treatment shows that the regular and sufficient treatment seduces the cardiac compilation of hyprtension.

suggested questions

comments
Fetching comments Fetching comments
Sign in to be able to follow your search criteria
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا