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Register a new userRegression of Primary Gastric Low Grade Malt Lymphoma After Helicobacter Pylori Eradication
هجوع لمفوما النسيج اللمفاوي المرافق للمخاطية المعدية البدئية بعد استئصال الحلزونية البوابية
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Added by
Damascus University ورقة بحثية
Publication date
2005
fields
Medicine
and research's language is
العربية
Authors
نمير دعبول( باحث )
Created by
Shamra Editor
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أجريت الدراسة في مشفى المواساة الجامعي على 20 مريضاً سورياً بالغـاً مـن الجنسـين شُخَّصتْ عندهم لمفوما MALT معدية بدئية منخفضة الخباثة في المرحلـة E1 مترافقـة بالحلزونية البوابية و عولجوا فقط باستئصال الحلزونية البوابيـة. و قـد أدى العـلاج هـذا لاستئصال الحلزونية البوابية عند جميـع المرضـى (%100) و إلـى هجـوع %85 مـن اللمفومات هجوعاً تاماً و لم يظهر النكس طيلة فترة المتابعة التي تجاوزت خمس سـنوات. و تراجعت اللمفومات التي لم تستجب لهذا العـلاج (%15) علـى الـرغم مـن استئصـال الحلزونية البوابية بعد العلاج الكيماوي و دون اللجوء للجراحة أو للعلاج الشعاعي.
20 Syrian adult patients from both sexes underwent study at Al-Mouassat Hospital diagnosed with primary gastric E1 MALT lymphoma, Associated with H.P. and treated only with H.P. eradication. This treatment led to H.P. eradication in all patients (100%), and complete regression of 85% of Lymphoma. Relapse did not appear during follow up period which exceeded 5 years in all patients, 15% cured after chemotherapy without surgery nor radiotherapy.
Artificial intelligence review:
Research summary
تتناول هذه الدراسة التي أجراها الدكتور نمير دبول في مستشفى المواساة بدمشق تأثير استئصال جرثومة المعدة (Helicobacter Pylori) على تراجع لمفومة النسيج اللمفاوي المرتبط بالغشاء المخاطي للمعدة (MALT). شملت الدراسة 20 مريضًا سوريًا من كلا الجنسين تم تشخيصهم باللمفومة الأولية للمعدة من نوع MALT المرتبطة بجرثومة المعدة. أظهرت النتائج أن استئصال الجرثومة أدى إلى تراجع كامل لللمفومة في 85% من الحالات، ولم يظهر أي انتكاس خلال فترة المتابعة التي تجاوزت خمس سنوات. بينما تم علاج 15% من الحالات المتبقية باستخدام العلاج الكيميائي دون الحاجة إلى الجراحة أو العلاج الإشعاعي. تتوافق هذه النتائج مع الأدبيات الطبية الحالية، مما يدعم التوصية ببدء العلاج باستئصال جرثومة المعدة في حالات اللمفومة الأولية للمعدة من نوع MALT.
Critical review
تعد هذه الدراسة خطوة مهمة في فهم تأثير استئصال جرثومة المعدة على تراجع لمفومة MALT. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة صغير نسبيًا (20 مريضًا)، مما قد يؤثر على تعميم النتائج. ثانيًا، لم يتم توضيح تفاصيل حول مقاومة الجرثومة للمضادات الحيوية المستخدمة في العلاج، وهو عامل مهم يجب أخذه في الاعتبار. أخيرًا، كان من المفيد تضمين مجموعة مقارنة لمزيد من التحقق من فعالية العلاج. على الرغم من هذه النقاط، فإن الدراسة تقدم إسهامًا قيمًا في مجال علاج لمفومة MALT.
Questions related to the research
-
ما هو الهدف الرئيسي من الدراسة؟
الهدف الرئيسي هو دراسة تأثير استئصال جرثومة المعدة على تراجع لمفومة النسيج اللمفاوي المرتبط بالغشاء المخاطي للمعدة (MALT).
-
كم عدد المرضى الذين شملتهم الدراسة؟
شملت الدراسة 20 مريضًا سوريًا من كلا الجنسين.
-
ما هي نسبة التراجع الكامل لللمفومة بعد استئصال جرثومة المعدة؟
أظهرت النتائج أن استئصال الجرثومة أدى إلى تراجع كامل لللمفومة في 85% من الحالات.
-
ما هي التوصية النهائية للدراسة؟
توصي الدراسة ببدء العلاج باستئصال جرثومة المعدة في حالات اللمفومة الأولية للمعدة من نوع MALT، يليها العلاج الكيميائي في حال فشل الاستئصال.
References used
Greenlee R, Hill-Harmon M, Murray T et al: Cancer Statistics, 2001. CA Cancer J Clin 2001;51:15-30
Isaacson PG,Spencer J.Wright DH. Classifying primary gut lymphomas. Lancet 1988; 2:1148-9
Isaacson PG,Spencer J. Malignant Lymphoma of mucosa –associated lymphoid tissue. Histopathology 1987;11:445-62
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of 2013 and to
study the relationship with Age and sex
Methods: The complete records of all children admitted to the pediatric ward at Al-
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The mean lengths were not studied because of the age difference between the two groups.
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statistically significant differences in the distribution of infection by sex. H. pylori
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