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The relationship between helicobacter pylori infection and short stature in children

علاقة الإنتان بالملوية البوابية بقصر القامة لدى الأطفال

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 Publication date 2018
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Objective: To study the relationship of H. pylori infection with short stature in children with upper gastrointestinal endoscopy with dudenal biopsy with the clotest test on the antrum biopsy for three years from the beginning of 2011 until the end of 2013 and to study the relationship with Age and sex Methods: The complete records of all children admitted to the pediatric ward at Al- Assad University Hospital and upper gastrointestinal endoscopy was performed for the first time with a dudenal biopsy and a histological study with rapid urease test on the antrum biopsy during the years 2011-2012-2013. Patients were divided into two groups : the infected group and the non-infected group based on the clotest result. The differences in standard deviations of the lengths of the two groups were studied. The mean lengths were not studied because of the age difference between the two groups. Results: The number of patients in the study sample was 180 patients with ages from 6 months to 14 years. Median age was (6) years. The distribution was 95 (52.8%) males and 85 (47.2%) females. Weight loss, short stature and abdominal pain were the main reasons for endoscopy. The rate of helicobacter pyloi infection was 76 children from 180 and the distribution was 51.3% for males and 48.7% for females. There were no statistically significant differences in the distribution of infection by sex. H. pylori infection was higher in older ages. The age groups were (3-6 years) and 6-9 years the biggest. Weight loss and shortness of stature were more pronounced in the group of patients compared to non-infected patients, and there was a statistically significant difference in the standard deviation of lengths in children with H. pylori compared to noninfected patients. There were no significant statistical differences in weight or gender.


Artificial intelligence review:
Research summary
تهدف هذه الدراسة إلى استكشاف العلاقة بين الإنتان بالملوية البوابية وقصر القامة عند الأطفال الذين أجري لهم تنظير هضمي علوي مع خزعة عفج واختبار clotest على خزعة غار بوابي خلال الفترة من 2011 إلى 2013. شملت الدراسة 180 طفلاً تتراوح أعمارهم بين 6 أشهر و14 سنة، حيث تم تقسيمهم إلى مجموعتين: مجموعة المصابين بالملوية البوابية ومجموعة غير المصابين. أظهرت النتائج أن نسبة الإصابة بالملوية البوابية كانت 42.3%، وكانت أعلى في الأعمار الأكبر، مع عدم وجود فروقات إحصائية هامة لتوزع الإصابة حسب الجنس. كما أظهرت الدراسة وجود فروقات إحصائية واضحة في الانحرافات المعيارية لأطوال الأطفال المصابين مقارنة بغير المصابين، بينما لم توجد فروقات هامة في الأوزان. توصي الدراسة باتخاذ تدابير صحية وبيئية للحد من انتشار الإنتان بالملوية البوابية والبحث الروتيني عن الإنتان في حالات قصر القامة مجهول السبب.
Critical review
تعتبر هذه الدراسة مهمة لأنها تسلط الضوء على مشكلة صحية شائعة بين الأطفال في سوريا، وهي الإنتان بالملوية البوابية وعلاقته بقصر القامة. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل تضمين تحليل للظروف الاقتصادية والاجتماعية للأطفال المشاركين، حيث أن هذه العوامل قد تؤثر بشكل كبير على النتائج. ثانياً، كان من الممكن توسيع العينة لتشمل عدد أكبر من الأطفال لزيادة دقة النتائج. أخيراً، يمكن أن تكون هناك حاجة لمزيد من الدراسات المستقبلية التي تستخدم تقنيات تشخيصية متعددة لتأكيد النتائج.
Questions related to the research
  1. ما هي نسبة الإصابة بالملوية البوابية بين الأطفال في الدراسة؟

    نسبة الإصابة بالملوية البوابية بين الأطفال في الدراسة كانت 42.3%.

  2. هل هناك فروقات إحصائية هامة لتوزع الإصابة بالملوية البوابية حسب الجنس؟

    لا، لم توجد فروقات إحصائية هامة لتوزع الإصابة بالملوية البوابية حسب الجنس.

  3. ما هي الأعراض السريرية الأكثر شيوعاً التي استدعت التنظير الهضمي؟

    الأعراض السريرية الأكثر شيوعاً التي استدعت التنظير الهضمي كانت نقص الوزن، قصر القامة، والألم البطني.

  4. ما هي التوصيات التي قدمتها الدراسة للحد من انتشار الإنتان بالملوية البوابية؟

    توصي الدراسة باتخاذ تدابير صحية وبيئية للحد من انتشار الإنتان بالملوية البوابية، والاستقصاء الروتيني عن الإنتان في حالات قصر القامة مجهول السبب باستخدام وسائل غير غازية.


References used
WARREN JR, MARSHALL B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 4;1(8336): 1983 Jun 1273-5
KATO S, SHERMAN PM. What is new related to Helicobacter pyloriinfection in children and teenagers? Arch Pediatr Adolesc Med. 159(5): 2005 May;415-21
HOOI JKY, LAI WY, NG WK,et al. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 153(2): 2017 Aug; 420-429
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