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Thoracic Small Round Cell Tumors

أورام الخلايا المدورة الصغيرة في الصدر

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 Publication date 2005
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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There is a group of tumors share the same nuclear size <3 red blood cells and can be differentiated only by immunostaining. All thoracic small cells tumors diagnosed between 1998-2001 during 4 years, at AL ASSAD UNIVERSITY HOSPITAL – DAMASCUS UNIVERSITY. There were 103 cases (66 cases of small cell carcinoma, 30 malignant lymphoma, and 7 cases of PNET ). We performed the immunostaining in 31 cases of small cell carcinoma ,all of them were malignant lymphomas and the 7 cases of PNET*. PNET cannot be diagnosed without immunostaining. We must demand the immunostaining if there is a doubt ( clinical or pathological) about the real nature of a small cell tumor.


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Research summary
تتناول هذه الدراسة الأورام الصغيرة المستديرة في منطقة الصدر، والتي تتشابه في حجم النواة وتختلف فقط من خلال التلوين المناعي. تم تشخيص جميع الأورام الصغيرة في الصدر بين عامي 1998 و2001 في مستشفى الأسد الجامعي بجامعة دمشق. تضمنت الدراسة 103 حالات (66 حالة من سرطان الخلايا الصغيرة، 30 حالة من الأورام اللمفاوية الخبيثة، و7 حالات من أورام PNET). تم إجراء التلوين المناعي في 31 حالة من سرطان الخلايا الصغيرة، وكلها كانت أورام لمفاوية خبيثة و7 حالات من PNET. لا يمكن تشخيص PNET بدون التلوين المناعي. يجب طلب التلوين المناعي إذا كان هناك شك (سريري أو مرضي) حول الطبيعة الحقيقية للورم الصغير.
Critical review
دراسة نقدية: الدراسة تقدم معلومات قيمة حول تشخيص الأورام الصغيرة المستديرة في منطقة الصدر باستخدام التلوين المناعي. ومع ذلك، يمكن أن تكون الدراسة أكثر شمولاً إذا تضمنت تحليلاً أعمق للعوامل المؤثرة في دقة التشخيص وأثر التلوين المناعي على نتائج العلاج. بالإضافة إلى ذلك، يمكن أن تكون هناك حاجة لمزيد من الدراسات لتأكيد النتائج وتوسيع نطاق البحث ليشمل أنواع أخرى من الأورام الصغيرة المستديرة.
Questions related to the research
  1. ما هي الفترة الزمنية التي غطتها الدراسة؟

    الدراسة غطت الفترة الزمنية بين عامي 1998 و2001.

  2. كم عدد الحالات التي تم تشخيصها في الدراسة؟

    تم تشخيص 103 حالات في الدراسة.

  3. ما هو الدور الأساسي للتلوين المناعي في تشخيص الأورام الصغيرة المستديرة؟

    التلوين المناعي ضروري لتحديد الطبيعة الحقيقية للأورام الصغيرة المستديرة، خاصة أورام PNET.

  4. ما هي أنواع الأورام التي تم دراستها في البحث؟

    تم دراسة سرطان الخلايا الصغيرة، الأورام اللمفاوية الخبيثة، وأورام PNET.


References used
Kummar PV.Fine needle aspiration cytologic findings in malignant small cell tumor of the thoracopulmonary region (Askin tumor).Cytol Act 1994 Sep ; 38 (5) 702-6
O’Sullivan JM,Perlman E,Furman J,Humphery P,Dehner L,Pfeifer J.Visceral Primitive Peripheral Neuroectodermal Tumors:A clinicopathologic and molecular study.Hum Path 2001;32:1109-1115
Barnoud R,Sabourin JC,Pasquier D,et al.Immunohistochemical expression of WT1 by desmoplastic small round cell tumor .A comparative study with other Small Round Cell Tumors.American Journal of Surgical Pathology 24(6);830-836,2000
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