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Register a new userThoracic Small Round Cell Tumors
أورام الخلايا المدورة الصغيرة في الصدر
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Added by
Damascus University ورقة بحثية
Publication date
2005
fields
Medicine
and research's language is
العربية
Authors
لينا الحفار( باحث )
Created by
Shamra Editor
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هو التعريف بوجود مجموعة من الأورام الصدرية التي تتشارك بحجم نوى أقل مـن ثـلاث كريات حمراء أو يساويها، و قد ظهرت الحاجة لمثل هذا التشخيص بسبب ظهور الرشـافات و الخزعات الدقيقة التي تغفل البنية النسيجية و يصعب وضع التشخيص النهـائي لهـا دون الاستعانة بالتلوينات المناعية. أجريت الدراسة في مشفى الأسد الجامعي بدمشق، على 103 حالات مشخصة ما بين شهري كانون الثاني 1998 و كانون الأول 2001 . وضع التشخيص الأولي لهـذه الأورام بواسـطة التلوين الاعتيادي بوصفها أوراماً ذات خلايا صغيرة مدورة، ثم أجريت التلوينات المناعيـة التي أسهمت في وضع التشاخيص النهائية أو تأكيدها. وجدت 66 حالة سرطانة صغيرة الخلايا، و 30 حالة لمفوما خبيثة منتـشرة و 7 حـالات ورم PNET. أسهمت التلوينات المناعية في تأكيد تشخيص نصف حالات السرطانة صغيرة الخلايا و كـان لها كل الفضل في تشخيص اللمفومات و ورم PNET المذكور مؤخراً و الـذي غـاب عـن التشخيص قبل عصر المناعيات. يجب عدم التردد بطلب التلوينات المناعية عند وجود أي شك عند الـسريري أو المـشرح المرضي.
There is a group of tumors share the same nuclear size <3 red blood cells and can be differentiated only by immunostaining. All thoracic small cells tumors diagnosed between 1998-2001 during 4 years, at AL ASSAD UNIVERSITY HOSPITAL – DAMASCUS UNIVERSITY. There were 103 cases (66 cases of small cell carcinoma, 30 malignant lymphoma, and 7 cases of PNET ). We performed the immunostaining in 31 cases of small cell carcinoma ,all of them were malignant lymphomas and the 7 cases of PNET*. PNET cannot be diagnosed without immunostaining. We must demand the immunostaining if there is a doubt ( clinical or pathological) about the real nature of a small cell tumor.
References used
Kummar PV.Fine needle aspiration cytologic findings in malignant small cell tumor of the thoracopulmonary region (Askin tumor).Cytol Act 1994 Sep ; 38 (5) 702-6
O’Sullivan JM,Perlman E,Furman J,Humphery P,Dehner L,Pfeifer J.Visceral Primitive Peripheral Neuroectodermal Tumors:A clinicopathologic and molecular study.Hum Path 2001;32:1109-1115
Barnoud R,Sabourin JC,Pasquier D,et al.Immunohistochemical expression of WT1 by desmoplastic small round cell tumor .A comparative study with other Small Round Cell Tumors.American Journal of Surgical Pathology 24(6);830-836,2000
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