ضبط تحرر دواء كيتوبروفن عن طريق صياغته في أقراص قالب تحوي على مشاركة بين بلمرات مختلفة و بنسب متغايرة. هدفت هذه الدراسة إلى تقصي تأثير مشاركة مشتقات عديد الميثاكريلات مع بلمر محب للماء في ضبط تحرر كيتوبروفن من أقراص القالب إِذ اختبرت أربعة أنواع مختلفة اللزوجة من ال HPMC.
For controlling the release of Ketoprofen from matrix tablets, combinations
between different polymers in different ratio were formulated.
Aim: The aim of this study is to investigate the applicability of HPMC combination with
Polymethacrylates (Eُudragit RS, RL & L100) for controlling the release of ketoprofen from matrix
tablets. Four types of HPMC with different viscosities were tested in the study.
References used
Sweetman Sean C., Susan L. handy, et al. Martindale 35. 2007; 1 : 62-63
Roda A., Sabatini L., Mirasoli M., Baraldini M., Roda E. Bioavailability of a new ketoprofen formulation for once-daily oral administration. Int J Pharm. 2002; 241 : 165–172
Mitchell J., Ford L., et al. The influence of concentration on the release of drugs from gels and matrices containing Methocel®. Int J Pharm. 1993; 100 :155–163
The objective of the present study was to formulate methyldopa sustained release
matrix tablets using hydrophilic hydroxypropyl methylcellulose (HPMC) alone or in
combination with hydrophobic ethyl cellulose polymer(EC). Matrix tablets were prepare
Methyldopa, an anti-hypertensive drug having a half life of less than 2 hours, and given with a dose of 250 mg 3-4
times daily.
Objective: The present study was for objective of developing a sustained release (SR) matrix tablets of methyldopa
usin
The present study aims to develop sustained release (SR) matrix tablets of methyldopa using
hydrophilic hydroxypropyl methylcellulose (HPMC), and to study the effect of some formulation
variables (HPMC concentration and viscosity grade, combination
The purpose of this study was to prepare prolonged release tablets of verapamil: matrix and coated tablets, because of the importance of these systems in drug delivery and improving the patient compliance and therapeutic efficacy .Different formula
The increasing number of individuals with diabetes suggests that diabetic retinopathy DR is
a major contributor to vision loss. The initial disease is characterized by increased vascular
permeability due to a breakdown in the blood-retinal barrier