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Using Nifedipine for Inhibiting Preterm Labour: Management and Side Effects

استعمال النيفيدبين في تثبيط المخاض الباكر - التدبير و الآثار الجانبية

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 Publication date 2013
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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A Study was conducted on a random sample of (100) cases of pregnancies with preterm labour admitted to Al-Assad University Hospital Obstetrics and Gynecology section Lattakia during the period April 2012 until April 2013. The efficiency of using nifedipine for inhibiting pre-term labour was studied together with the side effects during treatment and the cost of using nifedipine comparable to using another tocolysis. The percentage of success in using nifedipine for inhibiting preterm labour by 60 m.g method during the first 24h was (78.5%) while it was (81.1%) by 90 m.g method for the same period. The percentage of side effects was (19.7%) of which headaches were the most recurrent (50%). Using oral nifedipine costs less than using intravenous Salbutamol used to inhibit preterm labour at Al-Assad University Hospital.

References used
BEKKARI,Y; LUCAS,J; BEILLIT, T;CHERET,A; DREFUS,M. Tocolysis with nifedipine: its use in current practice. Gynecology Obstetric Fertil,French 2005 , Jul- Aug;33(7-8):483-7
CARITIS, N.STEVE. Nifedipine in the management of preterm labor: a systematic review and metaanalysis .American Journal of Obstetrics & Gynecology ,USA 2011 ,Vol 204, Issue 2, Pages 134
CHAN, L.W; SAHOTA, D.S; YEUNG, S.Y; LEUNG, T.Y; FUNG, T.Y;LAU, T.K; LEUNG, T.N.Side-effect and vital sign profile of nifedipine as a tocolytic for preterm labour. Fetal Medicine Unit, Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong 2008 Aug;14(4):267-7
CORNETTE,J; DUVEKOT,J; ROOS;HESSELINK,J; HOP,W; STEEGERS,E. Maternal and fatal hemodynamic effects of nifedipine in normotensive pregnant women .University Medical Centre, Rotterdam, the Netherlands ,BJOG, 2010,p78-132
Diallo.FB ;Diallo.Y; Camara.MK; Diallo. A; Cissoko. M; Lontsi. GR; Diallo.MS. Management of pre-term labor: use of nifedipine in Conakry, Guinea . Med Trop (Mars). 2010 Apr;70(2):141-4

Artificial intelligence review:
Research summary
تتناول الدراسة التي أجراها الدكتور أحمد عبد الرحمن جاسم العريب استخدام النيفيدبين في تثبيط المخاض الباكر، حيث أجريت على عينة عشوائية من 100 حالة من المريضات الحوامل في مشفى الأسد الجامعي باللاذقية خلال الفترة من أبريل 2012 إلى أبريل 2013. هدفت الدراسة إلى تقييم فعالية النيفيدبين في تثبيط المخاض الباكر، دراسة الآثار الجانبية الناجمة عن استخدامه، وتحديد التكلفة المادية مقارنة مع أدوية أخرى مثل السالبوتامول الوريدي. أظهرت النتائج أن نسبة نجاح النيفيدبين بجرعة 60 مغ خلال 24 ساعة الأولى بلغت 78.5%، بينما بلغت 81.1% بجرعة 90 مغ. كانت الآثار الجانبية بنسبة 19.7%، وكان الصداع الأكثر شيوعًا بنسبة 50%. كما تبين أن استخدام النيفيدبين أقل تكلفة مادية من السالبوتامول الوريدي. توصي الدراسة باستخدام النيفيدبين كخط أول في تثبيط المخاض الباكر نظرًا لفعاليته وقلة آثاره الجانبية وانخفاض تكلفته المادية.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في مجال التوليد وأمراض النساء، حيث تقدم معلومات قيمة حول فعالية النيفيدبين في تثبيط المخاض الباكر. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. على سبيل المثال، كان من الممكن توسيع حجم العينة لتشمل مجموعة أكبر من المريضات لضمان تعميم النتائج بشكل أفضل. كما أن الدراسة لم تتطرق بشكل كافٍ لتأثيرات النيفيدبين على الأجنة والولدان، وهو جانب مهم يجب مراعاته في الأبحاث المستقبلية. بالإضافة إلى ذلك، كان من الممكن تقديم تحليل أكثر تفصيلاً للآثار الجانبية وتقديم توصيات أكثر تحديدًا حول الجرعات المثلى.
Questions related to the research
  1. ما هي نسبة نجاح النيفيدبين في تثبيط المخاض الباكر بجرعة 60 مغ خلال 24 ساعة الأولى؟

    بلغت نسبة نجاح النيفيدبين بجرعة 60 مغ خلال 24 ساعة الأولى 78.5%.

  2. ما هي الآثار الجانبية الأكثر شيوعًا لاستخدام النيفيدبين في تثبيط المخاض الباكر؟

    الصداع هو الأثر الجانبي الأكثر شيوعًا، حيث بلغ نسبة حدوثه 50% من مجمل الآثار الجانبية.

  3. كيف تقارن تكلفة استخدام النيفيدبين مع السالبوتامول الوريدي في تثبيط المخاض الباكر؟

    استخدام النيفيدبين أقل تكلفة مادية من السالبوتامول الوريدي، حيث بلغت تكلفة النيفيدبين 10.8 ل.س خلال 24 ساعة مقارنة بـ 357 ل.س للسالبوتامول.

  4. ما هي التوصيات الرئيسية للدراسة بشأن استخدام النيفيدبين في تثبيط المخاض الباكر؟

    توصي الدراسة باستخدام النيفيدبين كخط أول في تثبيط المخاض الباكر نظرًا لفعاليته العلاجية وقلة آثاره الجانبية وانخفاض تكلفته المادية.

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Background& Objective: the early surgical intervention for neurological caludication cases which are often caused by severe degenerative lumbar canal stenosis gives excellent results especially on near term. To confirm that early surgical interventi on, early timing for severe lumbar canal stenosis which caused signs and symptoms of neurological claudication, can yield excellent functional and motor results for patient and it returns thim to good life activity. Materials & Methods: This study was done retrospectively for neurological caludication cases in elderly patients admitted to neurosurgery department at Al-assad university hospital in the period between 2007– 2010 year. (53) Patients underwent posterior laminectomy, with or without vertebral fixation accompanied. Results: The direct improvement of the surgery was 75 % for neurological claudication and 79% after one year of surgery. Radical pain accompanied with neurological clauication improved fully in 66 % directly after surgery, up 75 % after one year. The sensory symptoms were low grade improvement, which was about 56% partial improvement directly after surgery and fully in 34%up to 28% – 66%after one year of surgery. The complications were few and mild in (11 %). Conclusion: Early surgical intervention to all cases of neurological claudication especially in the elderly gives magnificent results (motor & sensory) with good functional activity improvement in comparison to conservative therapy.
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