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Breast cancer is the most widespread types of cancer among women. An efficient diagnosis in its early stage can give women a better chance of full recovery. Calcification is the important sign for early breast cancer detection. Mammography is the m ost effective method for breast cancer early detection using low radiation doses. The studies improved the sensitivity of mammogram from 15% to 30% based on Computer Auto-Detection CAD systems, which are used as a “second opinion” to alert the radiologist to structures that, otherwise, might be overlooked. This article summarizes the various methods adopted for micro-calcification cluster detection and compares their performance. Moreover, reasons for the adoption of a common public image database as a test bench for CAD systems, motivations for further CAD tool improvements, and the effectiveness of various CAD systems in a clinical environment are given.
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