Breast cancer is the most widespread types of cancer among women. An efficient
diagnosis in its early stage can give women a better chance of full recovery. Calcification
is the important sign for early breast cancer detection. Mammography is the m
ost effective
method for breast cancer early detection using low radiation doses. The studies improved
the sensitivity of mammogram from 15% to 30% based on Computer Auto-Detection CAD
systems, which are used as a “second opinion” to alert the radiologist to structures that,
otherwise, might be overlooked. This article summarizes the various methods adopted for
micro-calcification cluster detection and compares their performance. Moreover, reasons
for the adoption of a common public image database as a test bench for CAD systems,
motivations for further CAD tool improvements, and the effectiveness of various CAD
systems in a clinical environment are given.