Systemic mastocytosis (SM) is a rare malignant neoplasia,
which can create bone complications. The most frequent of those
is secondary osteoporosis, sometimes responsible for fractures,
especially of the rachis. We report the case of a 53 year-old
woman with 3 non-traumatic lombar fractures, leading to the
diagnosis of SM, after bone marrow trephine biopsy. We describe
the different types of bone involvement in MS, their
physiopathology, their diagnosis and treatment, with help of a
bibliographic review.