Objective: To study the relationship of H. pylori infection with short stature in
children with upper gastrointestinal endoscopy with dudenal biopsy with the clotest test on
the antrum biopsy for three years from the beginning of 2011 until the end
of 2013 and to
study the relationship with Age and sex
Methods: The complete records of all children admitted to the pediatric ward at Al-
Assad University Hospital and upper gastrointestinal endoscopy was performed for the
first time with a dudenal biopsy and a histological study with rapid urease test on the
antrum biopsy during the years 2011-2012-2013. Patients were divided into two groups :
the infected group and the non-infected group based on the clotest result.
The differences in standard deviations of the lengths of the two groups were studied.
The mean lengths were not studied because of the age difference between the two groups.
Results: The number of patients in the study sample was 180 patients with ages from
6 months to 14 years. Median age was (6) years. The distribution was 95 (52.8%) males
and 85 (47.2%) females. Weight loss, short stature and abdominal pain were the main
reasons for endoscopy. The rate of helicobacter pyloi infection was 76 children from 180
and the distribution was 51.3% for males and 48.7% for females. There were no
statistically significant differences in the distribution of infection by sex. H. pylori
infection was higher in older ages. The age groups were (3-6 years) and 6-9 years the
biggest. Weight loss and shortness of stature were more pronounced in the group of
patients compared to non-infected patients, and there was a statistically significant
difference in the standard deviation of lengths in children with H. pylori compared to noninfected
patients. There were no significant statistical differences in weight or gender.
gastric intestinal metaplasia (GIM) is considered to be a precursor of gastric cancer
which is still the fourth most common cancer and second leading cause of cancer related
death worldwide after lung cancer. There is also a relationship between ga
stric intestinal
metaplasia and H.pylory which is one of the most important factors predisposing it . As a
result, H. pylori eradication is one of the most promising approaches in gastric cancer
prevention.
The aim of the study was investigated the prevalence of GIM and its subtypes, and
the prevalence of H. pylori infection in GIM.
the study was conducted on 200 patients who were undergoing
esophagogastroduodenoscopy (EGD) with biopsy between January 2016 and April 2017,
in the university hospitals of Tishreen university. Specimens were stained with
hematoxylin and eosin to determine the pattern of intestinal metaplasia. And Helicobacter
pylori was investigated by Giemsa staining.
The prevalence of GIM was 16%. The prevalence of complete IM was higher than
incomplete IM. The prevalence of H. pylori infection was 50% in GIM, without presence
of statistical importance ) P > 0.05). The prevalence of chronic gastritis was 100% in GIM
(P Value = 0.02). Gastric intestinal metaplasia was more prevalent in older patients.
GIM is a common finding in patients undergoing EGD with biopsy in our region.
Chronic gastritis is considered as the most important reason for the development of GIM.
This study aimed to know the relation between cagA positive Helicobacter pylori (HP) strains and diseases such as gastric and duodenal ulcers and gastric adenocarcinoma. The study included 61 dyspeptic patients from gastrointestinal (GI) endoscopy de
partment patients in Al-Assad university hospital in Lattakia. During upper (GI) endoscopy, gastric biopsy specimens were obtained for Clo-test and histologic examination. Blood was obtained from Clo-test positive patients for serologic tests of HP and cagA. After upper (GI) endoscopy and histologic examination, patients were divided into 4 groups: chronic gastritis (28 patients), gastric ulcer (5 patients), duodenal ulcer (17 patients) and gastric adenocarcinoma (11 patients).
CagA antibodies were positive in 68.85% of patients. The difference in the proportion of CagA antibody positive between the four groups was highly significant
(P= 0.006).
The highest positive proportion was in gastric adenocarcinoma (90.91%) then duodenal ulcer (88.24%) then gastric ulcer (80%), while the lowest positive proportion was in chronic gastritis (46.43%). There was no difference in HP antibody levels between the four groups (P = 0.90) but these levels were significantly higher in cagA+ patients compared to cagA- (P= 0.05). This study found a positive relation between cagA+ and diseases such as peptic ulcer and gastric adenocarcinoma in Syria .
20 Syrian adult patients from both sexes underwent study at Al-Mouassat
Hospital diagnosed with primary gastric E1 MALT lymphoma, Associated
with H.P. and treated only with H.P. eradication. This treatment led to H.P.
eradication in all patients (
100%), and complete regression of 85% of
Lymphoma.
Relapse did not appear during follow up period which exceeded 5 years in
all patients, 15% cured after chemotherapy without surgery nor
radiotherapy.
The aim of this study is to determine the incidence of helicobacter pylori
(HP) in patients with chronic gastroduodenitis and to compare the clinical
presentations between patients with positive HP chronic gastroduodenitis
and those with negative
HP. Also, To compare the endoscopic findings
between patients with HP positive gastroduodenitis and HP negative
children.
Gastroduodenoscopy was done for every child with abdominal pain
admitted at the children hospital-Damascus University between 2002-2003.
Mucosal biopsy was taken from every patient who had gastroduodenitis
diagnosed by gastroduodenoscopy.
The percentage of patients with gastroduodenitis having HP positive
erosions was 48.38 %.
Higher percentage of HP positive patient was more present in those with the
erosion and sub-atrophy forms.
