The Bcl-2 family of proteins has been implicated as a necessary factor in the
death caused by a large number of different agents of a wide variety of cell
types. Cystine is a precursor for the biosynthesis of the intracellular Thiol,
(glutathione)
GSH.
The mechanism by which Bcl-2 resist cystine deprivation induced apoptosis
was investigated in hepatocyte Hepz/Bcl-2 and Hepz/pEF cell lines.
