This study was conducted in the laboratories of the Faculty of Science In the spring
on 2013, after being subjected to gavage for 4 weeks through a standard diet supplemented
fat by 3% to two groups (6animales per group) the experimental group beca
me aqueous
extract 150 mg/kg Body weight for 4weeks while the control group became standard food
and tap water ad libitum.
The Blood samples were collected each week, and then the serum samples were
taken to the biochemical tests to determine total cholesterol, triglycerides and glucose
levels in biochemistry laboratory of the Institute of Intermediate medical in Tishreen
University.
Blood glucose control reduces the microvascular and macrovascular
complications in patients with diabetes mellitus type II. According to the American Diabetes Association, less than a half of those with diabetes achieve optimal control of blood gluc
ose and target values of HbA1c. Life style modifications is one of the preferences of diabetes management because the potential relationship between diet and diabetic control. So nutrition therapy which given by dietitian and generally lifestyle modifications are considered mainly integrated to traditional medication for disease.
The study included 104 patients with diabetes type II (HbA1c 8% ± 1.07, BMI 26.45 ± 2.69, fasting blood glucose 148.25 ± 33.76) given diabetes self-management education program and divided into two groups. The first group was treated with glibenclamide only and the second was treated with a combination of glibenclamide and metformin. After three months monitoring, 103 patients Completed the study. Therapeutic efficacy was evaluated considering HbA1c ≤ 6.5% as a target value. The necessary statistical study to analyze the data and evaluate the statistical
significance of the results was made.
The results indicate that the treatment supported with life style
modifications was more effective than traditional therapy and patient education at blood glucose control in patients with diabetes mellitus type II and improve their health.
A known weight of Abrus seeds powder were soaked in cِhloroformmethanol
(2:1) and extracted for 18 hours, the mixture then filtrated and reextracted
with equal volume of water and evaporated to dryness. The crude
extract is regarded as cِhloroform
-methanol extract of Abrus Seeds (crab's eye).
Chloroform-methanol extract was analyzed by HPLC and GC-MS
chromatography for identification and purification of the extract components.
Trigonelline and Abrine were isolated, a solution of a definite concentration
was made from crab's eye extract and its pure components, trigonelline and
Abrine, then oral administration of this solution of a definite concentration
were given to the Alloxan diabetic rats.
