Platelets play a key role in the development and progression of atherosclerosis.
Platelet volume is an indicator of platelet activation and function, and it can be assessed by
platelet volume indices (PVI) such as mean platelet volume (MPV), platel
et distribution
width (PDW), and Platelet-large cell ratio (P-LCR). PVI are potentially useful markers for
the prediction of acute coronary syndromes. Thus our study aims to evaluate the
relationship between them and clinical features of coronary artery disease (CAD).
Our population is represented by 60 patients undergoing coronary angiography at Al-
Assad University Hospital, Lattakia, Syria. Patients were evenly divided into four groups
according to their clinical presentation; control group, stable angina group, unstable angina
group, and acute myocardial infarction (MI) group. PVI were measured in all patients.
We found a significant increase in MPV (P=0.04), PDW (P=0.03), and P-LCR
(P=0.03) in patients compared to healthy control subjects. We calculated the cutoff points
of these indices to help diagnosing the progressive atherosclerotic plague, P-LCR>28.7%
(P=0.01) [sensitivity 44%, specificity 93%], and diagnosing MI, PDW>13.8 (P=0.01)
[53%, 100%], MPV>10.4 (P=0.004) [60%, 93%], P-LCR>28.7 (P=0.003) [66%, 93%].
In conclusion, PVI are simple and easy methods that can be used as a predictive
marker in CAD patients.
Renal artery stenosis is an important clinical entity. its
importance lies in that it may be a treatable cause of
hypertension, and it is -when progress- a cause of chronic
renal failure. The causes of renal artery stenosis are
numerous, the most
common are: atherosclerosis and
fibromuscular dysplasia (accounts for more than 95% of
cases). Digital Subtraction Angiography (DSA) is the standard
reference in the radiologic diagnosis of renal artery stenosis,
but it carries the risk of being invasive procedure. Doppler
ultrasound is used in the evaluation of the renal arteries, and
it has the advantage of being non-invasive and inexpensive.
Hypertension
تصوير الأوعية بالطرح الرقمي
Digital Subtraction Angiography
ارتفاع الضغط
القصور الكلوي
تضيق الشريان الكلوي
التصلب العصيدي
خلل التنسج العضلي الليفي
التصوير الطبي
الإيكو دوبلر
الطبقي المحوري متعدد الشرائح
Renal Failure
Renal Artery Stenosis
Doppler Ultrasound
Multislice Computed Tomography
المزيد..
يشير مصطلح داء الشريان المحيطي بشكل شائع إلى الداء الذي يعيق جريان الدم إلى الطرفين ولكن هناك بعض الجدل حول هذا المصطلح حيث يستخدمه بعض المؤلفين لتوصيف داء الشرايين السباتية والحشوية والكلوية وداء شرايين الطرفين العلويين
The role of Interleukin-1 genes in the association between chronic periodontitis
and atherosclerosis has been under debate. The purpose of this study is to compare the existence of
interleukin1 genes polymorphism in the chronic periodontitis subjects with and without atherosclerosis.