اشترك بالحزمة الذهبية واحصل على وصول غير محدود شمرا أكاديميا
تسجيل مستخدم جديدCoupled bulk-surface free boundary problems arising from a mathematical model of receptor-ligand dynamics
54
0
0.0
(
0
)
اسأل ChatGPT حول البحث
ﻻ يوجد ملخص باللغة العربية
We consider a coupled bulk-surface system of partial differential equations with nonlinear coupling modelling receptor-ligand dynamics. The model arises as a simplification of a mathematical model for the reaction between cell surface resident receptors and ligands present in the extra-cellular medium. We prove the existence and uniqueness of solutions. We also consider a number of biologically relevant asymptotic limits of the model. We prove convergence to limiting problems which take the form of free boundary problems posed on the cell surface. We also report on numerical simulations illustrating convergence to one of the limiting problems as well as the spatio-temporal distributions of the receptors and ligands in a realistic geometry.
قيم البحث
اقرأ أيضاً
We prove existence, uniqueness, and regularity for a reaction-diffusion system of coupled bulk-surface equations on a moving domain modelling receptor-ligand dynamics in cells. The nonlinear coupling between the three unknowns is through the Robin bo
undary condition for the bulk quantity and the right hand sides of the two surface equations. Our results are new even in the non-moving setting, and in this case we also show exponential convergence to a steady state. The primary complications in the analysis are indeed the nonlinear coupling and the Robin boundary condition. For the well posedness and essential boundedness of solutions we use several De Giorgi-type arguments, and we also develop some useful estimates to allow us to apply a Steklov averaging technique for time-dependent operators to prove that solutions are strong. Some of these auxiliary results presented in this paper are of independent interest by themselves.
In this paper, we study a free boundary problem, which arises from an optimal trading problem of a stock that is driven by a uncertain market status process. The free boundary problem is a variational inequality system of three functions with a degen
erate operator. The main contribution of this paper is that we not only prove all the four switching free boundaries are no-overlapping, monotonic and $C^{infty}$-smooth, but also completely determine their relative localities and provide the optimal trading strategies for the stock trading problem.
In this paper, we investigate the convergence rates of inviscid limits for the free-boundary problems of the incompressible magnetohydrodynamics (MHD) with or without surface tension in $mathbb{R}^3$, where the magnetic field is identically constant
on the surface and outside of the domain. First, we establish the vorticity, the normal derivatives and the regularity structure of the solutions, and develop a priori co-norm estimates including time derivatives by the vorticity system. Second, we obtain two independent sufficient conditions for the existence of strong vorticity layers: (I) the limit of the difference between the initial MHD vorticity of velocity or magnetic field and that of the ideal MHD equations is nonzero. (II) The cross product of tangential projection on the free surface of the ideal MHD strain tensor of velocity or magnetic field with the normal vector of the free surface is nonzero. Otherwise, the vorticity layer is weak. Third, we prove high order convergence rates of tangential derivatives and the first order normal derivative in standard Sobolev space, where the convergence rates depend on the ideal MHD boundary value.
Recently 1, we presented a general theory for calculat- ing the strength and properties of colloidal interactions mediated by ligand-receptor bonds (such as those that bind DNA-coated colloids). In this communication, we derive a surprisingly simple
analytical form for the inter- action free energy, which was previously obtainable only via a costly numerical thermodynamic integration. As a result, the computational effort to obtain potentials of in- teraction is significantly reduced. Moreover, we can gain insight from this analytic expression for the free energy in limiting cases. In particular, the connection of our general theory to other previous specialised approaches is now made transparent. This important simplification will significantly broaden the scope of our theory.
For a vectorial Bernoulli-type free boundary problem, with no sign assumption on the components, we prove that flatness of the free boundary implies $C^{1,alpha}$ regularity, as well-known in the scalar case cite{AC,C2}. While in cite{MTV2} the same
result is obtained for minimizing solutions by using a reduction to the scalar problem, and the NTA structure of the regular part of the free boundary, our result uses directly a viscosity approach on the vectorial problem, in the spirit of cite{D}. We plan to use the approach developed here in vectorial free boundary problems involving a fractional Laplacian, as those treated in the scalar case in cite{DR, DSS}.
سجل دخول لتتمكن من نشر تعليقات
التعليقات
جاري جلب التعليقات
سجل دخول لتتمكن من متابعة معايير البحث التي قمت باختيارها
