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Register a new userIdentification of Biologically Important Compounds In Neem Leaves Through GC-MS Analysis
تحديد المركبات المهمة بيولوجيًا في أوراق النيم من خلال تحليل GC-MS
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النيم (Azadirachta indica A. Juss.) هو أحد أنواع الأشجار الهامة المعروف بامتلاكه، خصائص طاردة للديدان، مانعة للحمل ، مضادة للميكروبات .مضادة لمرض السكر ومهدئة لذلك ، هدفت الدراسة الحالية إلى تحديد المركبات المختلفة الموجودة في مستخلص أوراق النيم وتسجيل الأنشطة البيولوجية المختلفة .لهذه المركبات من خلال مسح الأدبيات الاساليب: تم الحصول على مستخلص النيم بنقع 100 .متبوعًا بالترشيح جم من أوراق البودرة الجافة في 1000 مل ميثانول. تم تجزئة هذا على التوالي باستخدام chloroform و n-hexane النتائج: .الكلوروفورم وتم تحديد 7 مركبات تم إجراء تحليل GC-MS لكسر ديكان (8.96٪) ؛ بنتانول ، أسيتات (9.72٪) ؛ -2 وشملت هذه ; 11-oxa-dispiro[4.0.4.1]undecan-1-ol (6.56%) nonanoic acid, 9-(3-hexenylidenecyclopropylidene)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (Z,Z,Z)- (7.13٪); quinoline-4-carboxamide, 2-phenyl-N-n-octyl- (9.79٪); (٪13.43) تتراتراكونتان و (٪نوناكوزان (44.27 الاستنتاجات: أظهر المسح الأدبي أن المركبات المحددة لها خصائص مضادة للجراثيم، ومضادة للفطريات ، ومضادة للسرطان، وسامة للخلايا ، ومضادة للالتهابات ، ومضادة للأكسدة.
Neem (Azadirachta indica A. Juss.) is an important tree species that is known to posses anthelmintic, contraceptive, antimicrobial, antidiabetic and sedative properties. Therefore, the present study aimed to identify various compounds present in the leaf extract of neem and to enlist various biological activities of these compounds through literature survey. Methodology: Extract of neem was obtained by soaking 100 g dry powdered leaves in 1000 mL methanol followed by filtration. This was successively fractioned using n-hexane and chloroform. Results: GC-MS analysis of the chloroform fraction was performed and 7 compounds namely 2-pentanol, acetate (9.72%); decane (8.96%); 11-oxa-dispiro[4.0.4.1]undecan-1-ol (6.56%); nonanoic acid, 9-(3-hexenylidenecyclopropylidene)-, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (Z,Z,Z)- (7.13%); quinoline-4-carboxamide, 2-phenyl-N-n-octyl- (9.79%); nonacosane (44.27%) and tetratriacontane (13.43%) were identified. Conclusion: Literature survey showed that the identified compounds possessed antibacterial, antifungal, anticancer, cytotoxic, anti-inflammatory, antioxidant, and antiviral properties.
References used
Legua P., Domenech A., Martinez J. J., Sanchez-Rodriguez L., Hernandez F., Carbonell-Barrachina A. A. and Melgarejo P. Bioactive and volatile compounds in sweet cherry cultivars. J. Food Nutr. Res. 2017; 5:844-851.
Haron N. H., Toha Z. M., Abas R., Hamdan M. R., Azman N., Khairuddean M. and Arsad H. In vitro cytotoxic activity of Clinacanthus nutans leaf extracts against hela cells. Asian Pac. J. Cancer Prev. 2019; 20:601-609.
Abdul-Hadi K. S., Fadhil H. L. and Hadi H. I. Using gas chromatography-mass spectrum and FT-IR techniques for methanolic extract of Digitalis purpurea and investigation of its anti-microbial activity. EBSCO Inf. Ser. 2018; 9:1305-1310.
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