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Liver resection for colorectal metastases

قطع الكبد الجراحي للنقائل الورمية من سرطانات القولون و المستقيم

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 Publication date 2018
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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Introduction: Liver surgery is a relatively recent and relatively major complex surgery, due to the anatomical and histological specialty of the liver Objective of the research: To evaluate the results of the cases of liver metastases from colorectal carcinoma from November 2010 until the end of April 2017.The study included 11 patients with 63,4% of females and average age of 55,4 years. The primary tumor was located in the rectum at 36.4%. in 4 cases (36.4%) was the livermetastases as a synchron with the main tumor while the metachron metastases was in 63.6% of cases. The single metastases was found at 72.7% while the multiple metastases accounted for 27.3%. The transfusion diameter was less than 5 cm in 5 cases and 45.4% and it was larger or equal to 5 cm in 54.6% of all the cases. The liver resection for Hepatocellular lesions were performed concurrently with primary tumor resection in the colon in only one case and the metastases was a single and 9.1% of the cases. The most common surgical procedure was segment resection in 45.4% of all the cases. The left or right hemi hepatectomy was in two cases, 8.7% None of the patients had any complications which requiring a reoperation. Bleeding occurred in one case such as the Bilioma in one case and Biliary fistula occurred in two cases.


Artificial intelligence review:
Research summary
تتناول هذه الدراسة التي أجراها الدكتور عماد محمد أيوب موضوع قطع الكبد الجراحي للنقائل الورمية الناتجة عن سرطانات القولون والمستقيم. شملت الدراسة 11 مريضاً، وكانت نسبة الإناث 63.6% ومتوسط الأعمار 55.4 سنة. تم تشخيص النقائل الكبدية بشكل متزامن مع الورم البدئي في 36.4% من الحالات، بينما حدثت النقائل بشكل متأخر في 63.6% من الحالات. وجدت النقيلة الوحيدة في 72.7% من الحالات، بينما كانت النقائل المتعددة في 27.3% من الحالات. تم إجراء قطع الكبد للنقيلة بشكل متزامن مع استئصال الورم البدئي في حالة واحدة فقط، وكانت نقيلة وحيدة بنسبة 9.1%. كان الإجراء الجراحي الأكثر تواتراً هو قطع قطعة أو قطعتين كبديتين بنسبة 45.4%. لم تحدث أي وفيات خلال الأشهر الثلاثة الأولى بعد الجراحة، وكان معدل البقاء على قيد الحياة للسنة الأولى 100%، بينما كان معدل البقاء لمدة 3 إلى 5 سنوات 45%. تجاوزت حالة واحدة البقاء لمدة 5 سنوات. تشير الدراسة إلى أن الجراحة هي الطريقة الوحيدة الشافية للنقائل الكبدية الناتجة عن سرطانات القولون والمستقيم، وأن معدل البقاء على قيد الحياة يمكن أن يصل إلى 5 سنوات عند إجراء الجراحة.
Critical review
دراسة نقدية: تعتبر هذه الدراسة خطوة مهمة في مجال جراحة الكبد للنقائل الورمية من سرطانات القولون والمستقيم، إلا أن هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة صغير نسبياً (11 مريضاً فقط)، مما قد يؤثر على تعميم النتائج. ثانياً، لم يتم توضيح تفاصيل العلاج الكيميائي المستخدم بشكل كافٍ، مما يمكن أن يؤثر على نتائج الدراسة. ثالثاً، كان من الممكن تضمين مجموعة مقارنة من المرضى الذين لم يخضعوا للجراحة لتقييم الفعالية بشكل أفضل. على الرغم من هذه النقاط، فإن الدراسة تسلط الضوء على أهمية الجراحة كخيار علاجي فعال للنقائل الكبدية.
Questions related to the research
  1. ما هي نسبة الإناث في الدراسة؟

    نسبة الإناث في الدراسة كانت 63.6%.

  2. ما هو متوسط عمر المرضى المشاركين في الدراسة؟

    متوسط عمر المرضى المشاركين في الدراسة كان 55.4 سنة.

  3. ما هو معدل البقاء على قيد الحياة للسنة الأولى بعد الجراحة؟

    معدل البقاء على قيد الحياة للسنة الأولى بعد الجراحة كان 100%.

  4. كم عدد الحالات التي تم فيها إجراء قطع الكبد بشكل متزامن مع استئصال الورم البدئي؟

    تم إجراء قطع الكبد بشكل متزامن مع استئصال الورم البدئي في حالة واحدة فقط.


References used
A Chiappa , E Bertani , R Biffi , U Pace , G Viale , G Pruneri , G Zampino , N Fazio , F Orsi , G Bonomo , L Monfardini , P Della Vigna and B Andreoni. Resection of colorectal liver metastases following neoadjuvant chemotherapy. ecancer 2007, 1:58 DOI: 10.3332/ecancer.2008.58
Matteo Donadon, Dario Ribero, Gareth Morris-Stiff, Eddie K. Abdalla, and Jean- Nicolas Vauthey. New Paradigm in the Management of Liver-Only Metastases From Colorectal Cancer Gastrointest Cancer Res 2007 1:20–27. © 2007
Kristen Little, MSPA, PA-C.Is a surgical CURE in the future for colorectal cancer liver metastasis. International Journal of Surgery Oncology (2017) 2:e34
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Hepatitis C is affected by human behaviors especially drugs , diets ,activities smoking , sexy behaviors and alcohol , so it is very important to change health behaviors by patient to control of disease and avoid complications . Objective : to ass ess the effects of health behaviors on liver function among hepatitis C patients .Setting :The study was carried out in the Chronic Liver Hepatitis Center in Alwatany hospitalization in Lattakia province.Subjects::Thesample comprised 40 patients chosen randomly from the two genders who have hepatitis C out in the chronic liver hepatitis center in Alwatany hospitalization in Lattakia province during the research time. Tool :Data were collected using the following tools:Tool I Questionnaire: It was developed by the researcher and include items related to: demographic patients data , clinical data , questions about ( patients , information of disease , risk factors, healthy behaviors : (diet – treatment regimens – activities and habits)) Tool II : Liver function assessment sheet by using Child Pugh scale.Tool III :Patientcompliance check list which include questions about complianceGuidenceProshor.guide line has been developed by the researcherThe patients participated in 3 sessions .Each session (45minutes).Results: liver function were advanced of patient at the experimental group which applied the guide line more than patient at the control group because of Appling guide line .Recommendations : Chronic Liver Hepatitis Centers have been containing proshorsshow the impact of these health behaviors on the liver work and performing their functions as normal.
The aim of this investigation was to compare between liver pate mixtures manufactured from local raw materials and determine the best mixture. Twelve pate mixtures with three types of livers (sheep, chicken, calf) and different concentrations of w ater and fat were prepared and analyzed for microbial counts (aerobic, anaerobic, yeast, mold, Staphylococcus spp, Salmonella spp, Listeria, mono- cytogenes, Pseudomonas aeruginosa, Clostridium spp, E.coli O157:H7 ،Campylobacter spp), emulsion stability and sensory evaluation to determine the acceptability of the pate mixtures. Microbiologically, most of raw materials which used to prepare the pate mixtures were going with Syrians Standard (No. 2179, 2007), The mixtures were free of the aerobic microbial counts after the completion of the sterilization process. Sheep fat was better than vegetable oil for processing liver pate mixtures. According to sensory evaluation and emulsion stability, the mixture No12 containing 10 % of three types of liver, 30% sheep fat and 20% water was the best.
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