Subscribe to the gold package and get unlimited access to Shamra Academy
Register a new userSkin and oral challenge tests performed on 20 patients with suspected beta-lactam allergy in Tishreen University Hospitals – Lattakia
اختبارات التحسس الجلدية و اختبارات التحدي الفموية عند 20 مريض لديهم اشتباه بالحساسية على البتالاكتامينات في مشافي جامعة تشرين - اللاذقية - سورية
523
0 0
0
(
0
)
Authors
غياث معروف( باحث )
Created by
Shamra Editor
Ask ChatGPT about the research
تعد البتالاكتامينات الصادات الحيوية الأكثر وصفاً و استهلاكاً في كل أنحاء العالم، كما يعتبر الارتكاس التحسسي عليها شائع عند العديد من المرضى إلا أن أقلية فقط من هذه الارتكاسات تنتج عن آلية تحسسية مناعية حقيقية. هنا نقدم تجربتنا في الاستقصاءات التحسسية على البتالاكتامينات في مشفى تشرين الجامعي في اللاذقية. لإثبات أو نفي الحساسية على البتالاكتامينات، تم إجراء اختبارات الحساسية الجلدية ( اختبارات الوخز و اختبارات الحقن داخل الأدمة باستخدام كل من المحددات الرئيسية الكبرى (PPL) و الصغرى (MDM) للبنسلين و البتالاكتامينات الحلولة عند 20 مريضاً سجلوا ارتكاساً أو أكثر عند استخدام صادات البتالاكتامينات. تم إجراء اختبارات التحدي الفموية عند المرضى في حال كانت الإختبارات الجلدية سلبية. أظهرت نتائجنا أن اختبارات التحسس الجلدية على البتالاكتاميات كانت إيجابية عند مريض واحد فقط. أكدت اختبارات التحدي الفموية نتائجنا إذ كانت سلبية عند المرضى الذين كانت اختباراتهم الجلدية سلبية. أكثر من ذلك هذه النتائج تظهر أن القيمة التشخيصية و القيمة التنبؤيه للإختبارات الجلدية على البتالاكتامينات هي جيدة بما أنه لم يشاهد اي اختبار تحدي إيجابي لدى المرضى ذوي اختبارات التحسس الجلدية السلبية. بالنتيجة، تعد هذه الدراسة الأولى في سوريا على الارتكاسات المباشرة على صادات البتالاكتامينات و قد أظهرت الحاجة لإجراء الإختبارات الجلدية عند المرضى المشتبه بحساسيتهم عليها لتأكيد أو نفي وجود هذه الحساسية بسبب الحاجة لهذه الأدوية واسعة الطيف و الخوف من إعطائها.
Betalactams are the most commonly prescribed antibiotics Antibiotics worldwide. Suspected allergic reactions to Betalactams are often reported in patients, but only a minority of these reactions results from real immunological mechanism. Here we present our experience in allergological investigation of Betalactam reactions in Tishreen University hospital in Lattakia. To confirm or rule out the suspected diagnosis, Skin tests (pricks and Intradermal tests with PPL (Penicilloyl-polylysine), MDM (minor determinants) and soluble Betalactams) were performed in 20 patients reporting one reaction or more to Betalactam antibiotics. Oral provocation tests (OPT) were performed in patients with negative skin tests. Our results showed that Skin tests to PPL, MDM and Betalactams were positive in only two patients. The OPT confirmed our results as they were positive in those two positive skin tests patients(allergy to Clavulanic acid).Moreover, these results suggest that the diagnostic and predictivevalue of skin teststo Betalactam antibiotics is good, as no positive OPT was observed in patients with negative skin tests. In conclusion, suspected allergic reactions to Betalactam antibioticsremain a relevantproblem due to the need ofthese wide variety of drugs. This is the first study in Syria to date on immediate allergic reactions to Betalactam antibiotics and it showed the necessity to performed skin tests in suspected patients.
References used
Ponvert CI, Perrin Y, Bados-Albiero A, Le Bourgeois M, Karila C, Delacourt C, Scheinmann P, De Blic J ; Pediatr Allergy Immunol. Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests 2011 Jun;22(4):411-8
Gomes ER, Demoly P. Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol. 2005;5:309–16
Blanca M, Romano A, Torres MJ, Fernandez J, Mayorga C, Rodriguez J, et al. Update on the evaluation of hypersensitivity reactions to betalactams. Allergy. 2009;64:183–93
rate research
Read More
The study aims to determine the effect of the inevitable risk assessment on audit
tests. For this purpose, the Researcher has done a field survey by distributing a
questionnaire on the sample of the auditors, with whom the researcher could communic
ate.
56 questionnaires have been distributed, and 34 questionnaires from which have been
returned.
The results of data analysis showed that, there is consensus on the existence of a
positive, extrusive effect of the inevitable risk assessment on the audit tests. And based on
the results of the factorial analysis, the results showed that the inevitable risk could be
divided into three factors and the audit tests into two factors, by which we are able to study
the assessment effect for each factor of the inevitable risk on the components of the audit
tests.
Also, The results showed that the assessment of the first factor of the inevitable risk
affects positively on the first factor of the audit tests, while has no effect on the second
factor of the audit tests. But, for the second factor of the inevitable risk has been showed
that, its assessment affects positively on the first factor of the audit tests, while has no
effect on the second factor of the audit tests.
Finally, the results showed that the assessment of the third factor of the inevitable
risk has a reverse effect on both the first and the second factors of the audit tests.
Gastroesophageal reflux is one of the most common diseases in the world and his
most important symptoms is the heartburn. He requires surgical treatment in some
advanced cases.
The study was performed on 20 patients who underwent laparoscopic anti
-reflux
surgery in Al-Assad and tishreen university hospitals in Lattakia between 2011-2017 and
were followed for at least six months after surgery.
The analysis of the results showed a complete efficacy of this surgery in terms of
absence of clinical symptoms in patients and no need for medical treatment after surgery,
Absence of major complications and temporary swallowing only in 15% of cases.
Comparison with other studies has shown similar results in terms of effectiveness
and complications.
As a result of the study, we concluded that this surgery is low risk, highly effective,
and has few complications.
laparoscopic cholecystectomy has many features that make it preferable to open
surgery with a low incidence of complications.
The study was conducted on 877 patients who underwent laparoscopic
cholecystectomy at Al-Assad and Tishreen hospitals in
the period 2010-2017
The surgical method used and the reasons for conversion to open surgery were
studied in addition to the complications occurring during or after the surgery in terms of
occurrence rate and method of management of complications and the results of this
management.
The average age of patients was 46 years, the proportion of females was 64.5%, the
mean surgical time was 45 minutes.
The ratio of conversion to open surgery was 2.05% and the most common cause was
severe inflammation, "unclear calot`s triangle" and suspicion of malignancy.
Partial laparoscopic cholecystectomy was performed in 1.36% of cases and
peroperative complications occurred in 0.34% of cases and postoperative complications in
2.16% of cases.
Analysis of the results revealed that the rates of conversion for open surgery and the
incidence of complications are within the internationally accepted rates and that the results
of management of complications were satisfactory and consistent with the methods used
globally to manage complications.
We concluded that this surgery is safe and its complications are rare. We recommend
applying it in our hospitals . We have suggested some recommendations that can reduce
the complications of this surgery.
Aim of Study: This study aimed to assess the prevalence of some oral habits (mouth
breathing, infantile swallowing, digit sucking) among school children in Lattakia city.
Materials and Methods: This cross-sectional study was conducted on 825 childr
en aged
(8-12) years, from school children in Lattakia city. Information on oral habits was obtained
from the parents through a specially designed questionnaire. A clinical evaluation was also
done.
Results:.The results showed that the percentage of prevalence of oral habits in Lattakia
school children was 36.4% , and mouth breathing (22.8%) which was most commonly seen
followed by infantile swallowing (17.3%). Digit sucking was a less common habit seen in
only 5.8% .There were no differences in the prevalence of these habits between boys and
girls and there were no significant differences according to age .
Conclusions: The study showed high prevalence of these oral habits. This highlighted a
lack of awareness and care by families related to their children’s oral health as well as the
need to improve public health plans for orthodontic prevention so that future occurrence of
malocclusion can be avoided.
Pancytopenia is defined by reduction of all three formed elements of blood below the
normal reference . It may be manifestation of a wide variety of disorders , yet there exist
few published assessments of the frequencies of various etiologies , an
d these frequencies
exhibit substantial geographic variation . This study was carried out to investigate for and
to identify the causes of pancytopenia , to find out the frequency of different causes , to
determine the incidence of pancytopenia in relation to sex and age and to compare our
findings with those of other similar studies in different countries .This was a prospective
study conducted in Al-Asad and Tishreen academic hospitals in Lattakia city , Syria , ovar
a period of one year . A total of 113 patients with the diagnosis of pancytopenia were
enrolled in the study All patients underwent a detailed medical history and full physical
examination followed by blood sampling for the investigations i.e. complete blood count
with peripheral film , erythrocyte sedimentation rate ( ESR ) , liver function test , PT ,
HBsAg and Anti- HCV , ultrasonography of abdomen . All patients underwent bone
marrow aspiration and trephine biopsy for some patients. A definite female
preponderance was observed , 59 were female and 54 were male. The majority of cases
were encountered in the age group of more than sixty years old .Infiltration disorders were
the commonest cause that was observed in 38.1% followed by infections in 22.1% ,
megaloblastic anemia 12.4% , myelodysplasia 11.5%, aplastic anemia 7.1% ,
myelofibrosis 3.5% , hypersplenism 3.5% and systemic disorders 1.8% Detailed clinical
history and meticulous physical examination along with baseline hematological
investigations provide good information and help in systematic planning of further
investigations to diagnose pancytopenia's cause.
Log in to be able to interact and post comments
comments
Fetching comments
Sign in to be able to follow your search criteria
