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Comparison of giving simethicone and N-acetylcycteine in improving visibility prior to Esophagogastroduodenoscopy

المقارنة بين إعطاء السميتيكون و N-أستيل سيستئين قبل التنظير الهضمي العلوي في تحسين الأداء التنظيري

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 Publication date 2017
and research's language is العربية
 Created by Shamra Editor




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This study was done to evaluate the effectiveness of premedication with simethicone or N- acetylcysteine (NAC) on enhancing endoscopic visibility in patient undergoing Esophagogastroduodenoscopy. This was a Randomized Double –blind Clinical Trial. The study included 350 children, ranged in age from 6 months to 15 years. patients were randomly allocated into three groups to receive one of the following premedications (: group 1 : Placebo, group 2: N- acetylcysteine, group 3: simehticone) with 10 ml of water at 20 minutes before Esophagogastroduodenoscopy .It was rated the amount of foam and air bubbles ,and divided into four degrees from 0 to3 degree, The scores of foam and air bubbles were compared and the duration of endoscope also compared between the three groups. The amount of foam/air bubbles was significantly lower in the simeticone group compared with the placebo and NAC group (p 0,0001) The duration of endoscopy was shorter in the simeticone group (P 0,0001)


Artificial intelligence review:
Research summary
هدفت هذه الدراسة إلى تقييم فعالية التحضير الدوائي باستخدام السميتيكون وN-أستيل سيستئين في تحسين الرؤية أثناء التنظير الهضمي العلوي. تضمنت الدراسة 350 طفلاً تتراوح أعمارهم بين 6 أشهر و15 سنة، وتم تقسيمهم عشوائيًا إلى ثلاث مجموعات: مجموعة بلاسيبو، مجموعة N-أستيل سيستئين، ومجموعة السميتيكون. تم إعطاء الأدوية مع 10 مل من الماء قبل 20 دقيقة من التنظير. تم تقييم كمية الفقاعات الهوائية والرغوة وتقسيمها إلى أربع درجات من 0 إلى 3، بالإضافة إلى قياس مدة التنظير. أظهرت النتائج أن كمية الفقاعات الهوائية والرغوة كانت أقل بشكل كبير في مجموعة السميتيكون مقارنة مع البلاسيبو وN-أستيل سيستئين، كما كانت مدة التنظير أقصر في مجموعة السميتيكون. توصي الدراسة باستخدام السميتيكون في بروتوكول التحضير قبل التنظير الهضمي العلوي.
Critical review
تعتبر هذه الدراسة إضافة قيمة إلى الأدب الطبي في مجال تحسين الرؤية التنظيرية عند الأطفال. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل تضمين مجموعة أكبر من المرضى لزيادة قوة النتائج. ثانيًا، لم يتم مناقشة الآثار الجانبية المحتملة للسميتيكون وN-أستيل سيستئين بشكل كافٍ. ثالثًا، كان من الممكن أن تكون الدراسة أكثر شمولية إذا تم تضمين مرضى من فئات عمرية مختلفة أو من خلفيات صحية متنوعة. أخيرًا، كان من المفيد تقديم مزيد من التفاصيل حول كيفية اختيار الجرعات المستخدمة في الدراسة.
Questions related to the research
  1. ما هي الأدوية التي تم تقييمها في هذه الدراسة لتحسين الرؤية التنظيرية؟

    تم تقييم السميتيكون وN-أستيل سيستئين في هذه الدراسة لتحسين الرؤية التنظيرية.

  2. ما هي الفئة العمرية للأطفال المشاركين في الدراسة؟

    تراوحت أعمار الأطفال المشاركين في الدراسة بين 6 أشهر و15 سنة.

  3. ما هي النتائج الرئيسية للدراسة فيما يتعلق بكمية الفقاعات الهوائية والرغوة؟

    كانت كمية الفقاعات الهوائية والرغوة أقل بشكل كبير في مجموعة السميتيكون مقارنة مع مجموعة البلاسيبو وN-أستيل سيستئين.

  4. ما هي التوصية الرئيسية للدراسة بناءً على النتائج؟

    توصي الدراسة باستخدام السميتيكون في بروتوكول التحضير قبل إجراء التنظير الهضمي العلوي.


References used
COHEN, J. SAFDI, M. A. DEAL, S. E. et al., “Quality indicators for esophagogastroduodenoscopy,” American Journal of Gastroen - terolog, vol. 101, no. 4, 2006, pp. 886–891
LEWIS, B. S. ; SWAIN, P. “Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding: results of a pilot study,” Gastrointestinal Endoscopy ,vol.56,no.3, 2002,pp. 349–353
KWAN V. ; DEVIERE, J. “Endoscopy essentials: preparation,sedation, and surveillance,” Endoscopy, vol. 40, no. 1, pp. 65–70, 2008
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