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Comparison of giving simethicone and N-acetylcycteine in improving visibility prior to Esophagogastroduodenoscopy

المقارنة بين إعطاء السميتيكون و N-أستيل سيستئين قبل التنظير الهضمي العلوي في تحسين الأداء التنظيري

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 Publication date 2017
and research's language is العربية
 Created by Shamra Editor




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This study was done to evaluate the effectiveness of premedication with simethicone or N- acetylcysteine (NAC) on enhancing endoscopic visibility in patient undergoing Esophagogastroduodenoscopy. This was a Randomized Double –blind Clinical Trial. The study included 350 children, ranged in age from 6 months to 15 years. patients were randomly allocated into three groups to receive one of the following premedications (: group 1 : Placebo, group 2: N- acetylcysteine, group 3: simehticone) with 10 ml of water at 20 minutes before Esophagogastroduodenoscopy .It was rated the amount of foam and air bubbles ,and divided into four degrees from 0 to3 degree, The scores of foam and air bubbles were compared and the duration of endoscope also compared between the three groups. The amount of foam/air bubbles was significantly lower in the simeticone group compared with the placebo and NAC group (p 0,0001) The duration of endoscopy was shorter in the simeticone group (P 0,0001)

References used
COHEN, J. SAFDI, M. A. DEAL, S. E. et al., “Quality indicators for esophagogastroduodenoscopy,” American Journal of Gastroen - terolog, vol. 101, no. 4, 2006, pp. 886–891
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KWAN V. ; DEVIERE, J. “Endoscopy essentials: preparation,sedation, and surveillance,” Endoscopy, vol. 40, no. 1, pp. 65–70, 2008
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