أجريت هذه الدراسة من أجل تقييم فعالية التحضير الدوائي بالسميتيكون أو N-أستيل سيستئين في تحسين الأداء التنظيري في المرضى الخاضعين للتنظير الهضمي العلوي . انها دراسة تجريبية Randomized Double –blind Clinical Trial شملت الدراسة 350 طفلا خضعوا لاجراء تنظير هضمي علوي بين عمر 6 أشهر و 15 سنة , تم تقسيم المرضى عشوائيا الى 3 مجموعات (المجموعة الاولى أعطيت Placebo و الثانية N-أستيل سيستئين و الثالثة سميتيكون) مع 10 مل ماء و قبل 20 دقيقة من التنظير الهضمي العلوي , تم تقييم كمية الفقاعات الهوائية و الرغوة المشاهدة أثناء التنظير و تقسيمها الى اربع درجات من 0-3 درجة. قورنت درجة الفقاعات الهوائية و الرغوة و كذلك مدة التنظير بين المجموعات الثلاث .
كمية الفقاعات الهوائية و الرغوة كانت أقل بشكل كبير في مجموعة السميتيكون مقارنة مع placebo و N- أستيل سيستئين (P 0,0001) , كذلك مدة التنظير كانت أقل في مجموعة السميتيكون (P 0,0001).
This study was done to evaluate the effectiveness of premedication with simethicone
or N- acetylcysteine (NAC) on enhancing endoscopic visibility in patient undergoing
Esophagogastroduodenoscopy. This was a Randomized Double –blind Clinical Trial. The
study included 350 children, ranged in age from 6 months to 15 years. patients were
randomly allocated into three groups to receive one of the following premedications
(: group 1 : Placebo, group 2: N- acetylcysteine, group 3: simehticone) with 10 ml of
water at 20 minutes before Esophagogastroduodenoscopy .It was rated the amount of foam
and air bubbles ,and divided into four degrees from 0 to3 degree, The scores of foam and
air bubbles were compared and the duration of endoscope also compared between the three
groups. The amount of foam/air bubbles was significantly lower in the simeticone group
compared with the placebo and NAC group (p 0,0001) The duration of endoscopy was
shorter in the simeticone group (P 0,0001)
References used
COHEN, J. SAFDI, M. A. DEAL, S. E. et al., “Quality indicators for esophagogastroduodenoscopy,” American Journal of Gastroen - terolog, vol. 101, no. 4, 2006, pp. 886–891
LEWIS, B. S. ; SWAIN, P. “Capsule endoscopy in the evaluation of patients with suspected small intestinal bleeding: results of a pilot study,” Gastrointestinal Endoscopy ,vol.56,no.3, 2002,pp. 349–353
KWAN V. ; DEVIERE, J. “Endoscopy essentials: preparation,sedation, and surveillance,” Endoscopy, vol. 40, no. 1, pp. 65–70, 2008
Introduction: Upper gastrointestinal system endoscopy is a safe and widely used procedure for diagnosis and treatment purposes. Endoscopic procedures can be painful and uncomfortable and patient cooperation is very important for a successful result.
The study included 77 patients admitted to Pediatric Department in AL-ASSAD
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