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Register a new userEffects of rhBMP-2 on some Biomarkers of Epithelial to Mesenchymal transition Process in the Gingival Epithelium
تأثير بروتين rhBMP-2 على بعض واسمات عملية التحول الظهاري الميزانشيمي في الظهارة اللثوية
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تمثل عملية التحول الظهاري الميزانشيمي مرحلة هامة في عملية الشفاء النسيجي ، لكنها أيضاً تعد مقدمة لعملية الغزو و التكاثر الورمي ، و قد أشارت العديد من الابحاث إلى تأثير العديد من عوامل النمو على هذه العملية. تهدف هذه الدراسة إلى تحري تأثير بروتين rh- BMP2 على واسمين أساسيين لهذه العملية هما بروتينا β-catenin و E-cadherin.
Epithelial to mesenchymal transition (EMT) process represents an essential stage for tissue healing، it is also considered as a preface for tumour proliferation and invasion. The current study aimed to investigate the effects of rhBMP-2 protein on two essential biomarkers for this process : β-catenin and E-cadherin.
References used
Zhang, Y.G., et al., [Construction and bio-activity of the chimeric protein of BMP2-EGFP]. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2005. 30(1): p. 16-20
Hata, K., [Clinical and preclinical application of PTH and BMP to dental treatment]. Clin Calcium :)3(26 .2116 ،p. 466-74
McCormack, N., E.L. Molloy, and S. O'Dea, Bone morphogenetic proteins enhance an epithelial-mesenchymal transition in normal airway epithelial cells during restitution of a disrupted epithelium. Respir Res, 2013. 14: p. 36
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:Bone morphogenetic proteins (BMPs) belong to the
family of transforming growth factors-β (TGF-β) and play an
essential role in the cellular proliferation and differentiation. Trails
that used immunohistochemistry have shown that Ki67 is existed i
n
all normal cells which is in proliferating phase and absent in
differentiated cells in resting phase.
Aim : to investigate the effects of rhBMP-2 on the proliferative
activity of rabbits bone tissue using Ki67 staining.
Recombinant human bone morphogenetic protein-2 (rhBMP-2 ) is
effectively to regenerate defects of the maxillary and mandible
bones. Such defects are sometimes caused by resection of oral
squamous cell carcinoma (OSCC) yet the biologic effects of
rhBMP-2 on this malignancy and its histological relations and the
ability of invasion and metastasis are not fully clear.
Aim of the study : this study aimed to investigate the effects of
rhBMP2 on E-cadherin expression , which plays a pivotal role in the
cellular adhesion through the adherent junctions.
The demographictrendsthat dominatedin the Syriansocietyin the last century, As the
declineinmortality rates, And the rapid rise of life expectancy at birth, And subsequent
decline in the birth rate high Which in turn reduced the rate of population
growth, which
contributed to the change ratios lengthy age groups(children and young people and the
elderly),This change contributed to increase the number of arrivals to the labor market.
This search monitors the role of demographic transition in changes in the Age
Structural Transition Syrian society And determine the phase experienced by the beginning
of the third millennium, Relying on data on birth and death rates and the percentage of the
population within the age groups lengthy in Syria so dependent to the results of the general
census of the population.
the most important results:
-theAgeStructural Transition in Syria Started since the mid-twentieth century.
-The growth rate rose class working-age population[64-15]year from (49%) of the
total population (1960)to (52.2%) in the year (1994), to reach (57.2%) (2004).
- Syria entered, the beginning of the new millennium, at the end of the second
phaseAnd the beginning of the third stage of Shift the and characterized by the expansion
of the number of people in middle age.
Oral epithelial dysplasia is a precancerous change develops in the oral mucosa, and
leukoplakia is the most common precancerous lesions in oral mucosa.
The epithelial-mesenchymal transition (EMT) is considered the mechanism through
which the oral
leukoplakia becomes malignant, and it's also responsible for the invasion
and metastasis of cancers. This study investigates the expression of β-catenin in epithelialmesenchymal
transition detected by immunohistochemical staining in the different grades
of oral epithelial dysplasia.
The sample consisted of 45 formalin-fixed, paraffin-embedded specimens of oral
leukoplakia with different grades of oral epithelial dysplasia; specimenswere
immunohistochemically stained with β-catenin antibody.
The control group was consisted of biopsies from the normal oral epithelia.
The EMT rates are associated with the severity of the oral epithelial dysplasia.That
means, the epithelial-mesenchymal transition marker β-catenin could be used to evaluate
the potentiality of malignant transformation in the precancerous lesions.
The aim of this study was to evaluate the effectiveness of
bilateral pedicle flap technique on gingival tissues recovery during three
months of clinical follow-up.
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