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Risk Factors of Esophagojejunal Anastomotic Leakage after Gastrectomy for Gastric Cancer

عوامل الخطورة للتسريب من المفاغرة المريئية الصائمية بعد استئصال المعدة بسبب السرطان

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 Publication date 2014
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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This is s retrospective analytic study of 27 cases of esophagojejunal anastomotic leakage after gastrectomy for gastric cancer during the period 1\1\1997 -1\1\2014 at AL Assad University Hospital, Lattakia, Syria. The most common risk factors of leakage were: factors related to the patient: (age, sex, hemoglobin level, total protein level, and albumin level); factors related to surgical resection: (combined resection of other organs, mechanical and manual esophago-jejunostomy) and factors related to the tumor: (tumor stage, tumor location, and ends of anastomosis free of tumor)


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Research summary
تناولت هذه الدراسة الاسترجاعية التحليلية 27 مريضًا تعرضوا لتسريب من المفاغرة المريئية الصائمية بعد استئصال المعدة بسبب السرطان في مشفى الأسد الجامعي باللاذقية خلال الفترة من 1997 إلى 2014. تم تقسيم عوامل الخطورة إلى ثلاثة أنواع: عوامل متعلقة بالمريض مثل العمر والجنس ومستويات الخضاب والبروتين والألبومين، وعوامل متعلقة بالعمل الجراحي مثل شمول العمل الجراحي لأعضاء أخرى وطريقة إجراء المفاغرة، وعوامل متعلقة بالورم مثل مرحلة الورم ومكان توضعه وسلامة حواف القطع الجراحي. أظهرت النتائج أن التسريب حدث بنسبة 1.91% من الحالات، وكانت نسبة الوفيات بين المرضى الذين حدث لديهم التسريب 22.22%. أوصت الدراسة بتحضير المريض جيدًا قبل الجراحة وتصحيح القيم المختلة للخضاب والبروتينات، واستخدام أجهزة الخياطة الآلية عند إجراء المفاغرة، وضمان سلامة حواف القطع الجراحي.
Critical review
دراسة نقدية: تعتبر هذه الدراسة مهمة لفهم عوامل الخطورة التي تؤدي إلى التسريب من المفاغرة المريئية الصائمية بعد استئصال المعدة بسبب السرطان. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، حجم العينة صغير نسبيًا (27 مريضًا)، مما قد يؤثر على تعميم النتائج. ثانيًا، لم تتناول الدراسة تأثير العوامل النفسية والاجتماعية على نتائج المرضى، والتي قد تكون لها دور مهم. ثالثًا، كان من المفيد تضمين تحليل متعدد المتغيرات لتحديد العوامل الأكثر تأثيرًا بشكل دقيق. على الرغم من هذه النقاط، توفر الدراسة رؤى قيمة يمكن أن تساعد في تحسين نتائج العمليات الجراحية المستقبلية.
Questions related to the research
  1. ما هي العوامل المتعلقة بالمريض التي تزيد من خطر التسريب بعد استئصال المعدة؟

    العوامل المتعلقة بالمريض تشمل العمر (أكبر من 70 سنة)، الجنس (الذكور)، مستويات الخضاب (أقل من 10 غ/دل)، البروتين الكلي (أقل من 5 غ/دل)، والألبومين (أقل من 3 غ/دل).

  2. ما هي نسبة حدوث التسريب من المفاغرة المريئية الصائمية بعد استئصال المعدة في هذه الدراسة؟

    نسبة حدوث التسريب كانت 1.91% من الحالات المدروسة.

  3. ما هي التوصيات التي قدمتها الدراسة لتقليل حدوث التسريب من المفاغرة؟

    التوصيات تشمل تحضير المريض جيدًا قبل الجراحة بتصحيح قيم الخضاب والبروتينات الكلية والألبومين، استخدام أجهزة الخياطة الآلية، وضمان سلامة حواف القطع الجراحي عند طرفي المفاغرة.

  4. ما هي العوامل المتعلقة بالورم التي تؤثر على خطر التسريب؟

    العوامل المتعلقة بالورم تشمل مرحلة الورم (مراحل متقدمة)، مكان توضع الورم (في الفؤاد)، وسلامة حواف القطع الجراحي (حواف مصابة بالورم).


References used
BUDISIN N, BUDISIN E. Early complications following total gastrectomy for gastric cancer. J Surg Oncol U.S.A.Vol. N°. 77,2001,35-41
ISOZAKI H, OKAJIMA K .Risk factors of esophagojejunal anastomotic leakage after total gastrectomy for gastric cancer. Hepatogastroenterology U.S.A.Vol. N°. 44,1997,1509-12
JAHNE J, PISO P. 1114 total gastrectomies in the surgical treatment of primary gastric adenocarcinoma - a 30-year single institution experience. Hepatogastroenterology U.S.A.Vol. N°. 48,2001, 1222-6
LANG H, PISO P. Management and results of proximal anastomotic leaks in a series of 1114 total gastrectomies for gastric carcinoma. Eur J Surg Oncol U.S.A.Vol. N°. 126,. 2000; 26(2):168-71
CHARLES F. Schwartz's Principles of Surgery, Ninth Edition, The McGraw-Hill Companies, U.S.A, 2010 ,468–469
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