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Register a new userExpression of Human Epidermal and Transforming Growth Factor Receptors in Normal Bone Marrow Cells and Leukemic Cells (Myeloid Leukemia and Lymphatic Leukemia)
تعبير مستقبلات عامل النمو الظهاري و التحولي البشري في خلايا نقي العظم الطبيعية و خلايا ابيضاض الدم ( ابيضاض الدم النقوي و اللمفاوي)
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Damascus University ورقة بحثية
Publication date
2006
fields
Medicine
and research's language is
العربية
Created by
Shamra Editor
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الهدف من هذا البحث هو دراسة تعبير مستقبل عامل النمو الظهاري و التحولي فـي خلايـا نقي العظم الطبيعي و في حالة ابيضاض الدم النقوي و اللمفاوي ( الحاد و المـزمن ) لـدعم البحث في وظيفة مستقبلات عامل النمو الظهاري و التحولي في نمـو خلايـا نقـي العظـم و تطورها و التعبير الخبيث لهذه المستقبلات الذي يجعلها مرشحة كي تكون هـدفاً علاجيـاً كامناً في أمراض الدم الخبيثة.
The goal of this research is to study the expression of epidermal and transforming growth factor receptor in normal human bone marrow (BM) cell, and in leukemia ( myeloid and lymphatic leukemia ) which promoted the research for the function of EGFR receptors in the development and growth of BM cells and for malignancies expressing of the EGFR as potential therapeutic targets in blood cell malignant diseases.
References used
Allen TD, Dexter TM, Simmons PJ: Marrow biology and stem cell, in Dexter TM, Garland JM, Testa NG (eds): Colony-stimulating factors. New York, NY, Dekker, 1990, p 1
Anklesaria P, Texido J, Laiho M, Pierce JH, Greenberger JS, Massague J: Cell-cell adhesion mediated by binding of membrane anchored transforming growth factor α to epidermal growth factor receptors promotes cell proliferation. Proc Natl Acad Sci USA. 1990; 87(9):3289-93
Aronson S.A. Growth factor and cancer. Science (Wash.DC). 1991; 254: 1146-53
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