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Effect of an aqueous extract of oleander plant according to white created albino mouse which has got diabetes

تأثير المستخلص المائي لأوراق نبات الدفلة في الفئران البيضاء المستحدث فيها داء السكري

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 Publication date 2015
and research's language is العربية
 Created by Shamra Editor




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This research has done in aiming for the effect of extract of Nerium oleander plant in the level of blood sugar and total glucose , triple alglesiredat and total cholesterol on created albino mouse which has got diabetes. The results showed the following: - A Significant increase in the concentration on bothglucose, triple alglesiredat and cholesterol through a serum in the blood of created albino mouse which has got diabetes, while the weight decreases comparing to the control. - The injection of Aqueous extract led oleander leaves plant with dose of 200 mg / kg of mouse weight for a period of ten days to a significant decrease of concentration on glucose ,the rate of total cholesterol and triple alglesiredat, in addition to, the weight has returned to what it was before the injection.


Artificial intelligence review:
Research summary
يتناول البحث تأثير المستخلص المائي لأوراق نبات الدفلة على الفئران البيضاء التي تم استحداث داء السكري فيها. أظهرت النتائج أن هناك ارتفاعًا معنويًا في مستويات الجلوكوز والكوليسترول الكلي والغليسيريدات الثلاثية في دم الفئران المصابة بالسكري، بالإضافة إلى انخفاض وزنها مقارنة بالمجموعة الشاهدة. بعد حقن الفئران المصابة بالسكري بجرعة 200 ملغ/كغ من المستخلص المائي لأوراق الدفلة لمدة عشرة أيام، لوحظ انخفاض معنوي في مستويات الجلوكوز والكوليسترول الكلي والغليسيريدات الثلاثية، كما عاد وزن الفئران إلى ما كان عليه قبل الحقن. تشير النتائج إلى أهمية المستخلص المائي لأوراق الدفلة في خفض مستويات السكر والكوليسترول والدهون الثلاثية في الدم، مما يفتح المجال لاستخدامه في الصناعات الدوائية لعلاج مرض السكري. أوصى الباحثون بإجراء دراسات إضافية لفصل المكونات الفعالة في المستخلص ودراسة تأثيرها على مستوى البنكرياس لفهم آلية عملها بشكل أفضل.
Critical review
دراسة نقدية: يعتبر البحث خطوة مهمة نحو فهم تأثير المستخلصات النباتية على الأمراض المزمنة مثل داء السكري. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل توسيع نطاق الدراسة لتشمل عددًا أكبر من الفئران لضمان دقة النتائج. ثانيًا، كان من الممكن إجراء تحليلات إضافية لتحديد المكونات الكيميائية الفعالة بشكل أكثر دقة. ثالثًا، يجب توخي الحذر عند تطبيق النتائج على البشر، حيث أن تأثير المستخلصات النباتية قد يختلف بين الأنواع. وأخيرًا، كان من الممكن تضمين دراسات مقارنة مع أدوية السكري التقليدية لتقييم فعالية المستخلص بشكل أفضل.
Questions related to the research
  1. ما هو الهدف الرئيسي من البحث؟

    الهدف الرئيسي من البحث هو دراسة تأثير المستخلص المائي لأوراق نبات الدفلة على مستويات الجلوكوز والكوليسترول والغليسيريدات الثلاثية في الفئران المستحدث فيها داء السكري.

  2. ما هي الجرعة المستخدمة من المستخلص المائي لأوراق الدفلة في التجربة؟

    تم استخدام جرعة قدرها 200 ملغ/كغ من وزن الفأر لمدة عشرة أيام.

  3. ما هي النتائج الرئيسية التي توصل إليها البحث؟

    أظهرت النتائج انخفاضًا معنويًا في مستويات الجلوكوز والكوليسترول الكلي والغليسيريدات الثلاثية في دم الفئران المصابة بالسكري بعد حقنها بالمستخلص المائي لأوراق الدفلة، كما عاد وزن الفئران إلى ما كان عليه قبل الحقن.

  4. ما هي التوصيات التي قدمها الباحثون بناءً على نتائج الدراسة؟

    أوصى الباحثون بإجراء دراسات إضافية لفصل المكونات الفعالة في المستخلص ودراسة تأثيرها على مستوى البنكرياس لفهم آلية عملها بشكل أفضل، بالإضافة إلى الاستفادة الطبية من المكونات الفعالة في مجال الصناعة الدوائية لمرضى السكري.


References used
ABDULKAREEM,K.F.; ULAIWI,H.KH;MOHAMMED,H.R;HARFSH.A.H The effect of experimentally indused hyperglycemia by alloxan on some hematological parameters in rabbits. Wasit Journal for Science & Medicine,2(2),2009, 186
Al-FARWACHI, M.I. In vitro and in vivo Immunomodulatory activities of Nerium oleander, aqueous leaf extract in Rabbits. J Anim Vet Adv, 6(9),2007,1047-1050
AL-HILFY,J. Effect of Green Tea Aqueous Extract on Body Weight, Glucose Level, and Kidney Functions in Diabetic Male Albino Rats.Journal of AL-Nahrain university science,vol.15(3),2012,161-166
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