Do you want to publish a course? Click here

Effect of an aqueous extract of oleander plant according to white created albino mouse which has got diabetes

تأثير المستخلص المائي لأوراق نبات الدفلة في الفئران البيضاء المستحدث فيها داء السكري

1983   3   75   0 ( 0 )
 Publication date 2015
and research's language is العربية
 Created by Shamra Editor




Ask ChatGPT about the research

This research has done in aiming for the effect of extract of Nerium oleander plant in the level of blood sugar and total glucose , triple alglesiredat and total cholesterol on created albino mouse which has got diabetes. The results showed the following: - A Significant increase in the concentration on bothglucose, triple alglesiredat and cholesterol through a serum in the blood of created albino mouse which has got diabetes, while the weight decreases comparing to the control. - The injection of Aqueous extract led oleander leaves plant with dose of 200 mg / kg of mouse weight for a period of ten days to a significant decrease of concentration on glucose ,the rate of total cholesterol and triple alglesiredat, in addition to, the weight has returned to what it was before the injection.


Artificial intelligence review:
Research summary
يتناول البحث تأثير المستخلص المائي لأوراق نبات الدفلة على الفئران البيضاء التي تم استحداث داء السكري فيها. أظهرت النتائج أن هناك ارتفاعًا معنويًا في مستويات الجلوكوز والكوليسترول الكلي والغليسيريدات الثلاثية في دم الفئران المصابة بالسكري، بالإضافة إلى انخفاض وزنها مقارنة بالمجموعة الشاهدة. بعد حقن الفئران المصابة بالسكري بجرعة 200 ملغ/كغ من المستخلص المائي لأوراق الدفلة لمدة عشرة أيام، لوحظ انخفاض معنوي في مستويات الجلوكوز والكوليسترول الكلي والغليسيريدات الثلاثية، كما عاد وزن الفئران إلى ما كان عليه قبل الحقن. تشير النتائج إلى أهمية المستخلص المائي لأوراق الدفلة في خفض مستويات السكر والكوليسترول والدهون الثلاثية في الدم، مما يفتح المجال لاستخدامه في الصناعات الدوائية لعلاج مرض السكري. أوصى الباحثون بإجراء دراسات إضافية لفصل المكونات الفعالة في المستخلص ودراسة تأثيرها على مستوى البنكرياس لفهم آلية عملها بشكل أفضل.
Critical review
دراسة نقدية: يعتبر البحث خطوة مهمة نحو فهم تأثير المستخلصات النباتية على الأمراض المزمنة مثل داء السكري. ومع ذلك، هناك بعض النقاط التي يمكن تحسينها. أولاً، كان من الأفضل توسيع نطاق الدراسة لتشمل عددًا أكبر من الفئران لضمان دقة النتائج. ثانيًا، كان من الممكن إجراء تحليلات إضافية لتحديد المكونات الكيميائية الفعالة بشكل أكثر دقة. ثالثًا، يجب توخي الحذر عند تطبيق النتائج على البشر، حيث أن تأثير المستخلصات النباتية قد يختلف بين الأنواع. وأخيرًا، كان من الممكن تضمين دراسات مقارنة مع أدوية السكري التقليدية لتقييم فعالية المستخلص بشكل أفضل.
Questions related to the research
  1. ما هو الهدف الرئيسي من البحث؟

    الهدف الرئيسي من البحث هو دراسة تأثير المستخلص المائي لأوراق نبات الدفلة على مستويات الجلوكوز والكوليسترول والغليسيريدات الثلاثية في الفئران المستحدث فيها داء السكري.

  2. ما هي الجرعة المستخدمة من المستخلص المائي لأوراق الدفلة في التجربة؟

    تم استخدام جرعة قدرها 200 ملغ/كغ من وزن الفأر لمدة عشرة أيام.

  3. ما هي النتائج الرئيسية التي توصل إليها البحث؟

    أظهرت النتائج انخفاضًا معنويًا في مستويات الجلوكوز والكوليسترول الكلي والغليسيريدات الثلاثية في دم الفئران المصابة بالسكري بعد حقنها بالمستخلص المائي لأوراق الدفلة، كما عاد وزن الفئران إلى ما كان عليه قبل الحقن.

  4. ما هي التوصيات التي قدمها الباحثون بناءً على نتائج الدراسة؟

    أوصى الباحثون بإجراء دراسات إضافية لفصل المكونات الفعالة في المستخلص ودراسة تأثيرها على مستوى البنكرياس لفهم آلية عملها بشكل أفضل، بالإضافة إلى الاستفادة الطبية من المكونات الفعالة في مجال الصناعة الدوائية لمرضى السكري.


References used
ABDULKAREEM,K.F.; ULAIWI,H.KH;MOHAMMED,H.R;HARFSH.A.H The effect of experimentally indused hyperglycemia by alloxan on some hematological parameters in rabbits. Wasit Journal for Science & Medicine,2(2),2009, 186
Al-FARWACHI, M.I. In vitro and in vivo Immunomodulatory activities of Nerium oleander, aqueous leaf extract in Rabbits. J Anim Vet Adv, 6(9),2007,1047-1050
AL-HILFY,J. Effect of Green Tea Aqueous Extract on Body Weight, Glucose Level, and Kidney Functions in Diabetic Male Albino Rats.Journal of AL-Nahrain university science,vol.15(3),2012,161-166
rate research

Read More

It was used in this study (15) of the female mice . They were divided into three groups : control , and two experimental groups (five mice in each group) .The control group was given distilled water, while the first experimental group was received only Paraben daily ( 250 mg / kg of body weight). As the second experimental group was received daily together of Paraben and aqueous ginger extract ( 250 mg / kg of paraben and 250 mg / aqueous ginger extract ) for (18 ) day .
Many T2D use CAO as a laxative. We did not find sufficient research to explain CAO's potential effect on the levels of HbA1c in T2D patients. This study will study this effect. Rats (n=80) were divided into eight groups (n=10). Five groups (n=50) wer e injected with streptozotocin intravenously to induce T2D. One group was given CAO with empagliflozin, and the second was assigned CAO only daily. The third was assigned CAO every two days, with empagliflozin, which was given daily. A fourth was assigned CAO alone daily. Also, the fifth was given empagliflozin alone. In the healthy groups, one group was given CAO, and the other was given empagliflozin. Also, the last healthy group was not assigned any drug. CAO's result on HbA1c in healthy rats was noted to decrease when delivered alone for eight weeks. HbA1c of the diabetic groups showed no significant difference (P-value<0.05) when comparing the rats given CAO with empagliflozin, and the rats were given CAO only. There was also no noticeable effect among the groups of rats given CAO daily and every two days. This study explains that CAO does not lead to a significant difference in HbA1c levels in diabetic rats, even it did for healthy rats, and if given alone, CAO could affect HbA1c levels if given over a long period. Also, CAO has a noticeable impact on experimental rats that co-administered Empagliflozin on HbA1c levels, and that Empagliflozin effect is not significantly affected if taken with CAO.
The present study aimed to investigate the effect of calyx aqueous extract of Hibiscus sabdariffa on liver enzymes Alanine and Aspartate Transaminases (ALT and AST)level. (12) Rabbits were used and divided into two groups : (6) the experimental gro up and (6) control group ,the control group became distilled water , while the experimental group received aqueous extract, that was administrated orally in adose of150 mg / kg body weight (b.w.) daily for28 days .Then blood was collected each 48 hours , the serum samples were taken and prepared to the biochemical tests to determine Alanine and Aspartate Transaminases (ALT and AST)level.
This study was conducted in the laboratories of the Faculty of Science In the spring on 2013, after being subjected to gavage for 4 weeks through a standard diet supplemented fat by 3% to two groups (6animales per group) the experimental group beca me aqueous extract 150 mg/kg Body weight for 4weeks while the control group became standard food and tap water ad libitum. The Blood samples were collected each week, and then the serum samples were taken to the biochemical tests to determine total cholesterol, triglycerides and glucose levels in biochemistry laboratory of the Institute of Intermediate medical in Tishreen University.
The research was conducted to study the resistance of Nerium plant which are planting on sides of roads and the cities portals. The research was performed by studying the leaves of Nerium plant, through studying the length and weigh of the leaf, an d its area and water content. In addition to studying the wools and hiatus and chlorophyll concentration, and compared the results between the polluted region which is the entry of Banias City, and the control one which is the gardens of Tishreen University. Results showed non significant reduction in length, weight and area of the leaf in the polluted region compared with the control one. It attained (16.2 cm, 0.97 g and 26.3 cm2), respectively in the polluted region. Where it was (17.8 cm, 1.25 g and 27.7 cm2), for control region, respectively. Also, there was no significant differences in water content between the two studied regions. It attained respectively (52.2 and 53.9 %). Our results showed: - That a number of hiatus decreased, whereas the wools increased in the polluted region compared with control region insignificantly. The mean of a number of it was 12 in polluted region, compared with 14 in the control region. - A simple insignificant reduction in the concentration of chlorophyll A in polluted region compared with the control, where it attained (0.93 and 0.98), respectively. The Nerium oleander plant was resistance and tolerance to the air pollution.
comments
Fetching comments Fetching comments
mircosoft-partner

هل ترغب بارسال اشعارات عن اخر التحديثات في شمرا-اكاديميا