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Forensic Medical Importance of Some Biomarkers (Faees) in Alcoholic Determination:A Comparative Study in Toxicokinetics of Ethanol and Its Penetration Into the Eye Ball and ItsApplication in Forensic Medicine

الأهمية الطبية الشرعية لبعض الواسمات الحيوية الكيميائية (الإسترات الإيتيلية للحموض الدسمة) لتحديد الكحولية (دراسة مقارنة في الحركية السمية للإيتانول و الاستفادة من نفوذه إلى كرة العين (الخلط الزجاجي) و تطبيقاته في مجال الطب الشرعي)

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 Publication date 2011
  fields Medicine
and research's language is العربية
 Created by Shamra Editor




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The concentration of ethanol in blood and urine provides important evidence in criminal and civil litigation when alcohol- related crimes are investigated (e.g., drunk driving )Therefore. Ethanol analysis is the most frequently performed assay in forensic toxicology laboratories . .However, the risk for artifactual formation of ethanol, especially in postmortem specimens, always needs to be considered . It is often difficult to distinguish between postmortem ethanol production and antemortem alcohol ingestion . Ethanol synthesis could be produced by many species of bacteria or yeasts ,which is also influenced as storage temperature, and the interval between death and autopsy increase .


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Research summary
تتناول هذه الدراسة الأهمية الطبية الشرعية لبعض الواسمات الحيوية الكيميائية، مثل الإسترات الإيتيلية للحموض الدسمة، في تحديد الكحولية. تهدف الدراسة إلى تقديم تقنيات حديثة لتحليل الكحول ومستقلباته في السوائل الحيوية، مع التركيز على استخدام الخلط الزجاجي للعين كعينة مثالية في حالات الوفاة. تم تعديل خلية الانتشار التقليدية لتناسب التحاليل الميدانية، مما يتيح قياس تركيز الكحول بدقة في الدم والخلط الزجاجي للعين. النتائج أظهرت أن الخلط الزجاجي للعين يعد عينة ممتازة للتحري عن الكحول بعد الوفاة، نظراً لعزل العين تشريحياً وقلة تعرضها للتلوث الجرثومي. توصي الدراسة باستخدام الخلط الزجاجي كبديل عن السوائل الحيوية التقليدية كالدم والبول، مما يسهم في توفير الوقت والجهد والتكلفة في التحاليل الطبية الشرعية.
Critical review
دراسة نقدية: تعتبر الدراسة خطوة مهمة نحو تحسين دقة التحاليل الطبية الشرعية، إلا أن هناك بعض النقاط التي يمكن تحسينها. أولاً، الدراسة تركز بشكل كبير على الخلط الزجاجي للعين دون تقديم مقارنة شاملة مع جميع السوائل الحيوية الأخرى. ثانياً، لم تتناول الدراسة بعمق تأثير العوامل البيئية مثل درجة الحرارة والرطوبة على نتائج التحليل. ثالثاً، قد يكون من المفيد توسيع نطاق الدراسة لتشمل عينات من مختلف الأعمار والأجناس لتقديم نتائج أكثر شمولية. وأخيراً، يجب أن تتضمن الدراسة توصيات واضحة حول كيفية تطبيق النتائج في السياقات القانونية المختلفة.
Questions related to the research
  1. ما هي الأهمية الطبية الشرعية للخلط الزجاجي للعين في تحليل الكحول؟

    الخلط الزجاجي للعين يعد عينة مثالية للتحري عن الكحول بعد الوفاة نظراً لعزل العين تشريحياً وقلة تعرضها للتلوث الجرثومي، مما يسهم في توفير الوقت والجهد والتكلفة في التحاليل الطبية الشرعية.

  2. ما هي التعديلات التي أجريت على خلية الانتشار التقليدية في هذه الدراسة؟

    تم تعديل خلية الانتشار التقليدية لتناسب التحاليل الميدانية، مما يتيح قياس تركيز الكحول بدقة في الدم والخلط الزجاجي للعين.

  3. ما هي الفوائد التي تقدمها هذه الدراسة في مجال الطب الشرعي؟

    تقدم الدراسة تقنيات حديثة لتحليل الكحول ومستقلباته في السوائل الحيوية، مما يسهم في تحسين دقة التحاليل الطبية الشرعية وتوفير الوقت والجهد والتكلفة.

  4. ما هي التوصيات الرئيسية التي تقدمها الدراسة للأطباء الشرعيين؟

    توصي الدراسة باستخدام الخلط الزجاجي للعين كبديل عن السوائل الحيوية التقليدية كالدم والبول في تحديد الكحولية بعد الوفاة.


References used
Jickells S. ,Negrusy A.Clarke's analytical forensic toxicology .Pharmaceutical Press (2008) : 299-327
Steven B. Karch,M.D. Editor-in-Chief ( 2000). Drug Abuse Handbook
Jatlow P. ( 1990) Acute toxicology of ethanol ingestion . Role of the clinical laboratory .Am J Clin Pathol N0v; 74 (5) : 721-4
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