Recombinant human bone morphogenetic protein-2 (rhBMP-2 ) is
effectively to regenerate defects of the maxillary and mandible
bones. Such defects are sometimes caused by resection of oral
squamous cell carcinoma (OSCC) yet the biologic effects of
rhBMP-2 on this malignancy and its histological relations and the
ability of invasion and metastasis are not fully clear.
Aim of the study : this study aimed to investigate the effects of
rhBMP2 on E-cadherin expression , which plays a pivotal role in the
cellular adhesion through the adherent junctions.
Epithelial to mesenchymal transition (EMT) process represents an
essential stage for tissue healing، it is also considered as a preface
for tumour proliferation and invasion. The current study aimed to
investigate the effects of rhBMP-2 protein on
two essential
biomarkers for this process : β-catenin and E-cadherin.
:Bone morphogenetic proteins (BMPs) belong to the
family of transforming growth factors-β (TGF-β) and play an
essential role in the cellular proliferation and differentiation. Trails
that used immunohistochemistry have shown that Ki67 is existed i
n
all normal cells which is in proliferating phase and absent in
differentiated cells in resting phase.
Aim : to investigate the effects of rhBMP-2 on the proliferative
activity of rabbits bone tissue using Ki67 staining.
