this study Aimes to Investigate CXCR4 expression in primary head
and neck squamous cell carcinomas tumors in all clinical stages and
histological grades, then compare it with control normal oral
epithelial tissues.
Compare metastatic lymph nodes
CXCR4 expression with their
primary HNSCC tumors at high stages which associated with
metastatic lymph nodes.
Squamous cell carcinoma SCC is an important malignancy in
head and neck tumors , Its high stages resulting in poor survival
because of metastasis–especially lymph nodes- and secondary
tumors . lymph nodes LN have biological importance because of
their immunity role as a base of immunity defensive lines and lymphatic fluid purification, Recently chemokine receptors have been reported to be correlated with many malignancies ,In
particular CCR7.