Determination of Captopril in Pharmaceutical Formulations Using Spectrofluorimetric Method

A sensitive, simple and selective spectrofluorimetric method has been proposed for determination Captopril (CPT) in pure form and pharmaceutical preparations. This method depends on the formation of complex between Captopril and Copper (II) at pH=3.5.

Extraction of Copper(II)From Sulphates Phase using O,O Diphenyl [(E)-2-Cyano-1-Methylvinyl] Amido Phosphate and O,O Diphenyl [(E)-2-Cyano-1-Methylvinyl]Amido Thio Phosphate In Methane Dichloride

The study addresses the synthesis of two organic phosphoric compounds that have the P-NH-c bridge, They have the following chemical formula (PhO)2P(O)-NH-C(CH3)=CHCN ( abbreviated as PCNO) and The compound (abbreviated as PCNS) The compound were synthesized in the center of acetonitrile and having a strong base of sodium hydride NaH by Diphenyl chloro phosphate (PhO)2POCl compounds and Diphenyl chloro thio phosphate (PhO)2PSCl compound Respectively . Some of the physical and chemical properties of the synthetic composites, such as the melting point, dissolution , and the withdrawal of some important spectra such as the IR spectra and the NMR spectra were used in the extraction of the copper(II) Ions from the of medium sulphates, Lesson of Partition Coefficient Copper Dcu between aqueous medium of organic medium containing different concentrations of organic phosphorus compounds prepared previously. Partition Coefficient copper(II) ion distribution was studied in terms of the change in the value of PH (PH = 4 --- 6) at the constant concentration of the extract used previously .The Spectrophotometer for calculating copper concentrations was used Depending on absorption , and the two previous components were compared .

Synthesis of N2O2S2-Schiff base Ligand and Using it to Transport Cu2+ Through Bulk Liquid Membrane

New Schiff base (H2L) containing nitrogen-sulfur-oxygen atoms was synthesized by reaction of α,α'-bis(5- Bromo-2-carboxyaldehyde phenoxy)-1.4- xylene with aminothiophenol. Transport of copper ion across a bulk chloroform membrane containing Schiff base ligand (H2L) as carrier has been studied. The parameters influencing the transport efficiency such as composition of receiving phase, pH of the feed phase, carrier concentration in the membrane, EDTA concentration in the receiving phase, effect of temperature and time dependency of the process were studied and discussed. The amount of copper transport through the liquid membrane after 48 min., arrived to 100% at temperature 58°C.