P53:Its Role As Gardian of The Genome and in Apoptosis and Antioncogenesis

P53 is the guardian of genome from any alteration, its gene is called tumor suppressor gene . p53 checks any alteration in cell cycle ,and if the alteration happened p53 resolves or shares in activation proteins important in resolving , if the cellcouldn't resolve the alteration p53 leads it to apoptosis . goingthe cell out of this nature cycle and continuing its resistance and proliferation makes it a tumor celland that make p53 very important study.

Investigating the pathway of protein p53 inhibition in head and neck squamous cell carcinoma (Immunohistochemistry study)

The protein p53 is the guardian of the cell gene contents from changes, and the gene that produces it is called Tumor Suppressor Gene which mutates in 50% of Squamous cell carcinoma’s cases producing defective protein .Studies have not detailed theexpression ratio of the defective protein Within the cancer cells, also studies have less details about the cases which did not show a mutated protein.