Radiocontrast-induced nephropathy, is becoming increasingly common cause of
Acute kidney injury (AKI).The aim of the present prospective study was to find out the
incidence and outcome of CIN in patients undergoing coronary angiography. Over a one
year period [2014]. At al-Assad university Hospital-Syria. 54 patients , satisfied the criteria
for entering into the study.Median age was 56 yr All were followed for development of
acute renal failure. The incidence was found to be 22.2 % .12 developed some evidence of
acute renal failure .4 required dialysis acutely. There were 2 deaths. and pre existing renal
impairment is one of the risk factors for developing contrast induced nephropathy.
Serum Creatinine should be measured routinely in all patients
who are scheduled form coronary angiography.
Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane
glycoprotein. KIM-1 is highly up regulated in proximal tubular
cells following kidney injury. It consists of an extracellular portion,
a novel 6-cysteine immunoglobulin-like domain, 2 N-gl
ycosylation
sites, also contains one transmembrane domain and a short
cytoplasmic domain with a conservative tyrosine phosphorylation
site.
