The use of Nitros Oxide in the Conscious Sedation is the most frequently
used method in the Pediatric Dental Clinic to control the child behavior or
modify it.
For all of this we used Nitros Oxide in a clinical biological study to verify the
fact
s available about it and to know its side effects on the central nervous
system and to investigate the vital signs such as pulse, blood pressure, and
breathing ratio.
Aim of study: Comparing the efficacy of combination (Midazolam – Hydroxyzine)
with and without nitrous oxide and oxygen in sedating uncooperating school children
undergoing dental treatment.
Materials and Methods: This was a prospective, triple bl
ind, randomized, cross
over, clinical study of uncooperative school children in need of two sessions of Bilateral
mandibular dental treatment. 30 children ages (6-9) years, were randomly selected to
receive one of two regimens: Regimen (A) contain oral midazolam (M) 7.5 mg and
hydroxyzine (H) 10 mg with oxygen (O2) 100%, while Regimen (B) contain oral
midazolam (M) 7.5 mg and hydroxyzine (H) 10 mg with nitrous oxide\oxygen (N2O\O2)
50% . And in the second session, the other regimen was administered. the behavior was
assessed using modified Houpt rating scale by reviewing the records of patients in
pretreatment stage ( injection, rapper dam, operating dental drill without touching the tooth
then with touching it) and during treatment stages ( drilling, restoration ). Beside recording
the vital signs.
Results: Comparing the overall assessment of the two regimens the success rate was
(86.67%) in regimen (A) and (93.34%) in regimen (B). No significant statistical difference
existed between the two regimes. The vital signs remained within normal limits in all cases
and no series side effects appeared.
