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تسجيل مستخدم جديدDriven translocation of a polymer: fluctuations at work
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The impact of thermal fluctuations on the translocation dynamics of a polymer chain driven through a narrow pore has been investigated theoretically and by means of extensive Molecular-Dynamics (MD) simulation. The theoretical consideration is based on the so-called velocity Langevin (V-Langevin) equation which determines the progress of the translocation in terms of the number of polymer segments, $s(t)$, that have passed through the pore at time $t$ due to a driving force $f$. The formalism is based only on the assumption that, due to thermal fluctuations, the translocation velocity $v=dot{s}(t)$ is a Gaussian random process as suggested by our MD data. With this in mind we have derived the corresponding Fokker-Planck equation (FPE) which has a nonlinear drift term and diffusion term with a {em time-dependent} diffusion coefficient $D(t)$. Our MD simulation reveals that the driven translocation process follows a {em super}diffusive law with a running diffusion coefficient $D(t) propto t^{gamma}$ where $gamma < 1$. This finding is then used in the numerical solution of the FPE which yields an important result: for comparatively small driving forces fluctuations facilitate the translocation dynamics. As a consequence, the exponent $alpha$ which describes the scaling of the mean translocation time $<tau>$ with the length $N$ of the polymer, $<tau> propto N^{alpha}$ is found to diminish. Thus, taking thermal fluctuations into account, one can explain the systematic discrepancy between theoretically predicted duration of a driven translocation process, considered usually as a deterministic event, and measurements in computer simulations. In the non-driven case, $f=0$, the translocation is slightly subdiffusive and can be treated within the framework of fractional Brownian motion (fBm).
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