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Register a new userA Comparison of Two Dosing Regimens of Intravaginal Misoprostol for First and Second- Trimesters Pregnancy Termination
المقارنة بين طريقتين في استخدام الميزوبروستول عن طريق المهبل لإنهاء الحمل في ثلثية الأول و المتوسط
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الهدف من الدراسة: التعرف على ميزات الميزوبروستول في إنهاء الحمل في الثلـين الأول و الثاني، و تحديد الجرعة المجهضة المثلى و فواصل تكرارها. الطرائق: بلغ عدد المرضى 56 سيدة، قسمن عشوائياً إلى مجموعتين، ضـمت الأولـى 29 مريضة و الثانية 27 . طبق الميزوبروستول مهبلياً بجرعة أولية مقدارها 800 µg في الثلث الأول من الحمل، و 200 µg في الثلث الثاني، و طبق 200 µg كل 12 ساعة في المجموعـة الأولى و في الثانية كل 6 ساعات، و عدت الطريقة فاشلة عنـد مـرور 48 سـاعة و بقـاء محصول الحمل كاملاً داخل الرحم. النتائج : معدل الإسقاط في المجموعة الأولى 100 % في الثلث الأول، 5.95 % في الثـاني. يقابلها 100 % في المجموعة الثانية و في الثلثين. و بلغ متوسـط الـزمن الـذي اسـتغرقه الإسقاط في المجموعة الأولى في الثلث الأول 1.8 ساعة، و في الثـاني 2.20 ، يقابلهـا فـي المجموعة الثانية 4.12 و 8.17 ساعة على التوالي. و حدث الإسـقاط بجرعـة وحيـدة فـي 7.85 % من مرضى المجموعة الأولى في الثلث الأول، يقابلها 10 % في الثانية (001.0 < P) أما الآثار الجانبية فكانت متماثلة تقريباً بين المجموعتين. الخلاصة: إن تطبيق الميزوبروستول عن طريق المهبل فعال في إنهاء الحمل فـي الثلثـين الأول و الثاني، و أن خفض فترة تكرار الجرعة من 12 ساعة إلى 6 ساعات لا يحمـل أيـة فائدة معنوية.
Objective: To compare the effectiveness of Misoprostol administered intravaginally every 12 versus 6 hours for termination of pregnancy in the first and second trimesters. Methods: Fifty six pregnant patients at 7 – 22 weeks of gestation were randomized to receive 800 μg (first trimester) and 200 μg either every 12 or every 6 hours for 48 hours. Results: The incidence of abortion within 48 hours after initial dose, in the first trimester was 100% in the two groups, in the second trimester the incidences were 95.5 and 100%. The incidences of abortion by a single dose in the first trimester were 85 and 10% in the 12 and 6 hours groups respectively (P <0.001) The mean abortion intervals 8.3 , 20.2 and 12.4 hours in the 12 and 6 hour group respectively. Side effects were similar in both groups. Conclusion: Misoprostol administered vaginally is effective for termination of first and second trimester pregnancies in non scared uterus. Giving the medication at a shorter interval from 12 to 6 hours appeared to have no significant benefit.
References used
Altman D G. How large a sample ? In: Gore S M, Altman D G, eds. Statistics in Practice. London: British Medical Association, 1982: 6- 8
Garris R E, Kirkwood C F. Misoprostol: A prostaglandin E-1 analogue Clin pharm 1989; 8:627-644
Herting R L, Nissen C H. Overview of misoprostol clinical experience. Dig Dis Sci 1986; 31 (suppl 2) : 47s-54s
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In this study , 103 pregnant women with the diagnosis of missed abortion
in the second trimester of pregnancy had been accepted to terminate the
pregnancy, by one of two methods : In the first group (53 patients ) we
used vaginal Misoprostol (cyto
tec ) ; in the second group (50 patients) we
used the classic method by insertion of Foley catheter followed by
induction of uterine contractions by oxytocine . (intravenous infusion ) .
Abortion is the most common complication of early pregnancy, so that should be effectively managed with safe and appropriate procedures. Surgical evacuation of the uterus for management of first trimester abortions usually involves vacuum aspiration
or sharp curettage. Objective:To compare the complications of electric vacuum aspiration (EVA) and sharp curettage (D&C) for first trimester abortions, and detect the method that ensure more safety and efficacy. Subjects and methods: The study included one hundred women with incomplete abortion, missed abortion or blighted ovum, gestational age less than 12 weeks whom come to the department of obstetrics and gynecology at Al-Assad university hospital in Lattakia , Syria between 1 July 2013 and 1 July 2014. They were allocated into two groups, group A (n = 50) underwent EVA and group B (n=50) underwent D&C. The procedures were performed using the general anesthesia. We excluded: febrile state, clotting disorders, sever medical and surgical complications, unstable hemodynamic state. Results: Clinical characteristics were similar in the two groups. There were no reports of maternal deaths, cervical laceration, uterine perforation or blood transfusion recorded in the two groups. Blood loss was greater with D&C group than with EVA group (0.001). need an analgesic was greater with D&C group than with EVA group (0.002). Duration of operation and hospitalization was significantly shorter with EVA group than with D&C group. The two groups were similar in success procedure. Conclusion: The efficacy of EVA was the same as that of D&C in successful the procedure, but pain and blood loss were experienced more in the D&C group.
This study was organized to find out the role and the efficacy of Misoprostol
in treating postpartum hemorrhage unresponsive to traditional agents that
contract the uterus .
Place : Maternity hospital at Faculty of Medicine in Damascus university
Time : from 2, January, 2004 to 2, January, 2005 .
Number of patients : 18 patients who met the criteria in that period of time .
Criteria of selection : any patient with post partum hemorrhage due to
uterine atony that did not respond well to the administration of Oxytocin
and Metergin .
Misoprostol is an effective treatment of post partum hemorrhage due to
uterine atony unresponsive to Oxytocin and Metergin.
Our study confirms the results of international studies of effectiveness of the
use of misoprostol in treating post partum hemorrhage due to uterine atony.
This study aimed at arranging the items of cognitive abilities test (primary battery)
by using Rash s one parameter model , In addition ,different forms for interpreting the
individuals level of ability were carried out. The test was conducted on a
sample of (1081)
students from Lattakia schools and kindergarten . using "SPSS" program and Winsteps for
statistical treatment in accordance with Rasch Model. The results showed the necessity of
omitting (38) items of cognitive abilities test because they were not fitting the model. The
remain items that were left were (172). And proved the validity and the reliability of the
test. Moreover, the present study form criteria for percentiles rank, T scores, and
standardized intelligent quiescent that equal for the different individual ability.
This research was carried out in the Department of Obstetrics and Gynecology in Alassad Hospital of Tishreen University in Lattakia in the period between 5th of Jan 2012 to 1st of Aug 2013. The sample tested was divided into two groups: 100 pregnant
women, and 50 not pregnant.
The study showed that the ratio of the sensitivity of Pap test in pregnancy was 100%, and its quality was 76.74%. The Compatibility with overall histological diagnosis was 79.38%.
However, the ratio of the sensitivity of Colposcopy was 90.91% and its quality was 76.74%. The Compatibility with overall histological diagnosis was 78.35%.
Thus we conclude that both Pap Smear and colposcopy are safe and good scanning tools. They can be used in the preliminary prognosis for carcinomatous and precarcinomatous tumors through the duration of pregnancy.
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