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Register a new userSynthesis, Spectroscopic and biological activity Studies of Azo-Schiff base andMetal Complexes derived from 5-Methyltryptamine
تحضير و دراسة طيفية و فعالية بيولوجية لمعقدات آزو- أسس شف- المشتقة من 5 -مثيل تربتامين
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Damascus University ورقة بحثية
Publication date
2012
fields
Chemistry
and research's language is
العربية
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Shamra Editor
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حضرنا المرتبطة الجديدة آزو- أسس شيف 2- {1.5 – Dimethy l – 3 - [2 - (5 – methyl - 1 H – indol – 3 - yl) - ethylimino] – 2 – phenyl - 2,3 – dihydro - 1H – pyrazol – 4 - ylazo} – 5 – hydroxy - benzoic acid من تفاعل 1.5– ثنائي مثيل -3 ] -2)-5-مثيل -1-اندول -3 -ايل) اثيل ايمين ] -2-فنيل -3،2- ثنائي هايدرو-1-بيرازول-4-ايل أمين (A (مع حمض ميتا هدروكسي حمض البنزويل. حضرنا معقدات الخارصين (II ،(الكادميوم (II (والزئبق (II (مـع المرتبطـة آزو-أسـس شـيف و الـصيغة العامـة هي [MLCl .[إذ إن M = الخارصين (II ،(الكادميوم (II (و الزئبق (II .(درست المرتبطة و المعقـدات الجديدة بأطياف الأشعة ما تحت الحمراء و فوق البنفسجية - مرئية و أطياف الكتلـة و الطنـين النـووي المغنطيسي البروتوني و الكربوني و التحلل الحراري الوزني و التحليل العنصري و التحليل المعدني و تحديـد محتوى الكلور. و العزم المغنطيسي و الناقليـة المولاريـة. كمـا حـددت البـارامترات الثرموديناميكيـة ΔE*, ΔH *, ΔS* ΔG* و K باعتماد معادلة fern Red-Coats من أطياف التحلل الحراري الـوزني للمركبات و لكل مرحلة من مراحل التحلل. كما درست الفعالية البيولوجية للمركبات ضد أنواع منتخبة من .Escherichia coli and Staphylococcus aureus البكتري.
A novel Azo-Schiff base ligand L 2-[1.5-Dimethyl-3-[2-(5-methyl-1H-indol- 3-yl) - ethylimino] - 2 - phenyl - 2,3 - dihydro - 1H - pyrazol - 4 - ylazo] - 5- hydroxy -benzoic acid has been synthesized from reaction 1.5-Dimethyl-3-[2-(5- methyl- 1H - indol - 3 - yl) - ethylimino] - 2 - phenyl - 2.3 - dihydro - 1H - pyrazol - 4 - ylamine (A) with m-hydroxy benzoic acid. Then, its Zn(II), Cd(II) and Hg(II) complexes were synthesized with the general formula [ML1Cl] where M = Zn(II), Cd(II) and Hg(II) are reported. The ligand and its metal complexes have been characterized by elemental analysis, metal content, Chloride containing, molar conductance, FT-IR, 1H and 13C- NMR, UV-Vis spectra, magnetic susceptibility, thermal analysis, and mass spectra. The activation thermodynamic parameters, such as ΔE*, ΔH*, ΔS* ΔG* and K are calculated from the TGA curve using Coats-Red fern method. The all prepared complexes were assayed for antibacterial (Escherichia coli and Staphylococcus aureus) activities by disc diffusion method. The results indicate that all tested ligand and complexes show antibacterial activity against E. coli and S aureus, as gram negative and positive bacteria.
References used
Chakravarty, A. R. Nreddy, A. P. Santra, B. K. and Thomas, A. M., 2002. Copper Complexes as Chemical Nucleases. J. Indian. Chem. Sci, 114, pp. 319-401
Eichhorn, G. L. and Marzilli, L. G. 1994. Advances in Inorganic Biochemistry Models in Inorganic Chemistry, PTR prentice-Hall, Inc
Keypour, H. Salehzadeh, S. and Parish, R. V., 2002. Synthesis of two Potentially Heptadentate (N4O3) Schiff base Ligand Derived from Condensation of Tris-(3-amino propyl) amine and Salicylaldehyde or 4- hydroxysalicylaldehyde Ni (II) and Cu (II) complexes of the former ligand. J. Molecules, 7, pp. 140-144
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In this work the electrochemical behavior of Para-nitro aniline
and metoxy benzealdehyde was studied by cyclic voltammetric
method on glassy carbon electrode in alkaline medium . It was
found that the Para- nitro aniline needed five electrons to reduce to
the azo group.
macrocyclic hydrazone Schiff base was synthesized by reaction of
succinicdihydrazide, Adipicdihydrazide with acetylacetone, adipicdihydrazide
with terephtaldialdehide and sebacicdihydrazide with terephtaldialdehide.
This work was focused on the synthesis of tetradentate Schiff bases which
were prepared by condensation of salicylaldehyde with 1,4-diaminobenzene
and 1,3-diaminobenzene. The Schiff base ligands were checked by different
spectral technique (GC-MS,
1H-NMR, IR). The influences of shaking time on
the extraction of Cu (II) using solvent extraction technique was studied. Then
the Kinitic parameters were calculated from schemes which give best line
through drawing log (a-x) vs time or 1/(a-x) vs time or [Cu2+] vs time, whereas
(a-x) represents Cu(II) concentration in water phase and from it (n) reaction
order, (K) reaction rate constant (t1/2) reaction half between prepared ligand
and Cu (II) were calculated.
In this research we have synthesized a new macrocyclic Schiff base
containing N2O5 donor atomes which was prepared by reaction of 1,7- bis (6-
methoxy - 2 - formyl phenyl)-1,4,7,10,13-penta oxa tridecane with 4',4- oxy
dianiline.
Hetrocyclic compounds 5-(5-R-2-Furfurlidene)– barbituric acid were
obtained and their physical and chemical properties were studied. Their
structures were identified by spectoroscopic methods. This study proved by
1H-NMR Spectroscopy data that these compounds exist in S-cis form.
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