تمت في هذا البحث دراسة تأثير نوع و تركيز البوليمير على تحرر الفوروسيميد من محافظ صلبة حاوية على حثيرات مطولة التأثير محضرة باستخدام (Ethyl cellulose, Eudragit RL, Eudragit RS) بنسب مختلفة (6,8,12,15%) بطريقة التحثير الرطب wet granulation و باستخدام الكحول الإيزوبروبيلي كعامل محثر، و تمت تعبئة الحثيرات المحضرة ضمن محافظ عاتمة و أجري عليها اختبار التحرر وفق دستور الأدوية الأوروبي 2012. بينت نتائج الدراسة أن معدل تحرر الدواء من المحافظ يختلف تبعاً لنوع و تركيز اﻟبوليمير المستخدم، حيث أن الصيغ المحضرة باستخدام EC أبطأ تحريراً للمادة الدوائية تليها الصيغ المحضرة باستخدام EU(RS) ثم EU(RL) كما يقل تحرر الفوروسيميد بزيادة تركيز البوليمير المستخدم فكانت الصيغ ذات التركيز 15% الأبطأ تحريراً للمادة الدوائية تليها الصيغ ذات التركيز 12% ثم 8% ثم 6%.
The aim of the present study is to prepare extended hard capsules of furosemide using
Eudragit RL, Eudragit RS and Ethyl cellulose individually and in different ratios (6,8,12 and
15%). The granules were prepared by wet granulation using isopropyl alcohol as a
granulating agent and then filled into capsules. The influence of different concentrations and
type of polymer was studied. The prepared capsules assessed for their physicochemical
properties and in-vitro drug release studies. In vitro release data show that Ethyl cellulose
has more retardation than Eudragits, and Eudragit RS retards drug more than Eudragit RL
does. Furthermore, higher concentration of polymer tends to more retardation than lower
concentration.
References used
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UMMADI S.; SHRAVANI B. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences, Vol.3, 2013, 258-269
ROWE C. R.; SHESKEY J.P.; QUINN E. M. Handbook of Pharmaceutical Excipients, 6th ed, The Pharmaceutical Press, 2009
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