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Register a new userIntermittent Clonazepam For The Prevence Of Recurrent Febrile Seizures
الاستخدام المتقطع للكلونازيبام للوقاية من تكرر نوب الاختلاج الحروري
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Tishreen University ورقة بحثية
Publication date
2015
fields
Medicine
and research's language is
العربية
Authors
مازن غالية( باحث )
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Shamra Editor
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هدف البحث و أهميته: تعتبر الاختلاجات الحرورية الأكثر شيوعاً من إجمالي الاختلاجات عند الأطفال بنسبة 2- 5% بعمر أقل من 5 سنوات%. و يشكل خطر تكرار الاختلاجات الحرورية 50% عند الأطفال بعمر أقل من 12 شهر و 30% عند الأطفال بعمر أكبر من 12 شهر. و نظراً لكون الحالة مثيرة للهلع عند الأهل تأتي أهمية المعالجة الوقائية لمنع تكرر نوب الاختلاج، و لذلك كان هدف البحث دراسة فعالية و أمان الكلونازيبام كعلاج وقائي من تكرر نوب الاختلاج الحروري. أدوات و طرائق البحث:دراسة تجريبية شملت 40 مريض باختلاجات حرورية. تمّ تطبيق الكلونازيبام بجرعة 0.05 مغ/كغ/اليوم تمّ إعطاء مضادات الحرارة في حال حمى تتجاوز 38°،و تمّت متابعة كل المرضى كل 3 أشهر خلال سنة كاملة. النتائج: شملت الدراسة 35 طفل. لوحظ وجود سوابق عائلية لاختلاجات حرورية بنسبة 57.1% و سوابق صرع بنسبة 28.57%. الآثار الجانبية للكلونازيبام خفيفة و محتملة أشيعها الوسنبنسبة 14.28%. الإستجابة للعلاج المتقطع بالكلونازيبام: لم تسجل أي نوبة اختلاج حروري خلال فترة الدراسة بنسبة 97.1%. الخلاصة: يعتبر الكلونازيبام علاج وقائي فعّال و آمن و سهل الاستخدام بالنسبة للاهل للوقاية من تكرر نوب الاختلاج الحروري.
Objective: Febrile seizures are the most common seizures in children less than 5 years(2-5%),and the risk of its recurrence is 50%(>1year),30%(<1year).We focused on the effect and safety of the prophylaxis treatment of recurrent FS beacuase it is a terrifying case for the parents. Materials&Methods:This is a trial study on 40 patient with FS.Clonazepam was recommended 0.05mg/kg/d then anti e when fever exceed 38°.We did follow up every 3 month during one year. Results:we followed 35 patient, familial history of FS found in 57.1%,a history of epilepsy in 28.57%.clonazepam side effects were supportable the most common was lawson 14.28%,the efficacy of the treatment we didn’t noticed any episode of FS during the study 97.1%. Conclusion: Clonazepam is a safe and effective and easy treatement for the parents for the prophylaxis of FS recurrence.
References used
CHARBOL,B;DULAC,O;MANCINI,J;PONSOT,G. Neurologie Pediatrique.3° edition,editions Lavoisier,france,2010,293-296
LYON,G;EVARD.P.Neuropediatrie.2° edition.Masson,France,2000
Engel J Jr .Report of the ILAE classification core group.Epilepsia 2006;47:1558- 68
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