Aim of study: Comparing the efficacy of combination (Midazolam – Hydroxyzine)
with and without nitrous oxide and oxygen in sedating uncooperating school children
undergoing dental treatment.
Materials and Methods: This was a prospective, triple bl
ind, randomized, cross
over, clinical study of uncooperative school children in need of two sessions of Bilateral
mandibular dental treatment. 30 children ages (6-9) years, were randomly selected to
receive one of two regimens: Regimen (A) contain oral midazolam (M) 7.5 mg and
hydroxyzine (H) 10 mg with oxygen (O2) 100%, while Regimen (B) contain oral
midazolam (M) 7.5 mg and hydroxyzine (H) 10 mg with nitrous oxide\oxygen (N2O\O2)
50% . And in the second session, the other regimen was administered. the behavior was
assessed using modified Houpt rating scale by reviewing the records of patients in
pretreatment stage ( injection, rapper dam, operating dental drill without touching the tooth
then with touching it) and during treatment stages ( drilling, restoration ). Beside recording
the vital signs.
Results: Comparing the overall assessment of the two regimens the success rate was
(86.67%) in regimen (A) and (93.34%) in regimen (B). No significant statistical difference
existed between the two regimes. The vital signs remained within normal limits in all cases
and no series side effects appeared.
