Telmisartan is an antihypertensive drug that inhibits angiotensin II
receptors type AT1. Studies showed drug interactions with different
potentials. This study was intended to investigate the role of some
active ingredients acting on influx, efflu
x and metabolizing
enzymes in intestinal absorption of telmisartan prior to hepatic-pass
effect. Intestinal perfusion with venous sampling technique was
applied in rats by perfusing telmisartan in intestinal lumen, and
measuring its concentration and amount versus time.
